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Nelova 200 mg Capsule contains Nilotinib, an anticancer drug. In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells.
You are not recommended to take antacids and Nelova 200 mg Capsule at the same time. You are advised to take antacids containing magnesium hydroxide, aluminium hydroxide, and simethicone about two hours before or two hours after taking Nelova 200 mg Capsule . However, please consult a doctor before taking other medicines with Nelova 200 mg Capsule .
You are recommended to avoid grapefruit juice, grapefruit and any supplement containing grapefruit extract while taking Nelova 200 mg Capsule as it may increase the amount of Nilotinib in the body and cause serious side effects.
Alcohol
Consult your doctor
The interaction of Nelova 200 mg Capsule with alcohol is unknown. Please discuss with your doctor if you have any concerns regarding this.
Pregnancy
Unsafe
Nelova 200 mg Capsule is not recommended for use during pregnancy as it may harm the unborn baby. Therefore, inform your doctor if you are pregnant or planning for pregnancy before taking Nelova 200 mg Capsule . Also, you are advised to use effective birth control measures during treatment with Nelova 200 mg Capsule and for up to 2 weeks after the last dose of Nelova 200 mg Capsule .
Breast Feeding
Unsafe
You are recommended to avoid breastfeeding during treatment with Nelova 200 mg Capsule and for two weeks after the final dose. Inform your doctor if you are breastfeeding.
Driving
Caution
If you experience side effects such as dizziness or visual disorders, avoid driving or operating machinery until you are alert.
Liver
Caution
Inform your doctor if you have liver problems before taking Nelova 200 mg Capsule . Your doctor may adjust the dose if necessary based on your condition.
Kidney
Consult your doctor
Limited information is available on the use of Nelova 200 mg Capsule in patients with impaired kidney function. Therefore, if you have kidney problems, inform your doctor before taking Nelova 200 mg Capsule .
Children
Caution
Nelova 200 mg Capsule is not recommended for children below 1 year of age as the safety and effectiveness were not established.
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About Nelova 200 mg Capsule
Nelova 200 mg Capsule belongs to the class of anticancer drugs called tyrosine kinase inhibitors used in the treatment of Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Ph+ CML is a type of blood cancer that causes white blood cells to behave differently.
Nelova 200 mg Capsule contains Nilotinib which works by blocking the action of an abnormal protein (Bcr-Abl tyrosine kinase) produced by an abnormal Philadelphia chromosome that signals abnormal white blood cells (cancerous cells) to multiply. Thereby, it stops the multiplication and inhibits the growth of cancerous cells and then causes the death of these cells.
Take Nelova 200 mg Capsule as prescribed. You are recommended to take Nelova 200 mg Capsule for as long as your doctor has advised it for you based on your medical condition. Sometimes, Nelova 200 mg Capsule may cause common side effects such as vomiting, nausea, diarrhoea, headache, constipation, tiredness, and muscle and joint pain. Most of these side effects of Nelova 200 mg Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Nelova 200 mg Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Nelova 200 mg Capsule and for two weeks after completing the course of Nelova 200 mg Capsule . Nelova 200 mg Capsule is not recommended for children below one year of age. Drive only if you are alert as Nelova 200 mg Capsule may cause dizziness or visual disorders as side effects in some people. If you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Nelova 200 mg Capsule , contact your doctor immediately, as these might be symptoms of liver problems.
Uses of Nelova 200 mg Capsule
Medicinal Benefits
Nelova 200 mg Capsule contains Nilotinib, an anticancer drug used to treat Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). In chronic myeloid leukemia (CML) patients, a change in genetic material (DNA) triggers a signal that tells the body to produce more abnormal white blood cells (cancerous cells). Nilotinib works by blocking this signal and thus stops the production of cancerous cells. Nelova 200 mg Capsule is used in adults and children with newly diagnosed Ph+ CML in the chronic phase and in adults with Ph+ CML in the accelerated and chronic phase who did not tolerate or no longer benefit from other treatments, including Imatinib.
Directions for Use
Side Effects of Nelova 200 mg Capsule
Drug Warnings
If you are allergic to Nilotinib or any other medicines, please tell your doctor. Avoid taking Nelova 200 mg Capsule if you are pregnant or breastfeeding. You are recommended to use effective contraceptive methods while taking Nelova 200 mg Capsule and for two weeks after completing the course of Nelova 200 mg Capsule . Nelova 200 mg Capsule is not recommended for children below one year of age. Nelova 200 mg Capsule may affect the growth and development of children with chronic phase Ph+ CML. Some children and adolescents may have slower than normal growth while taking Nelova 200 mg Capsule . Therefore, your doctor will monitor the growth of your child at regular visits. Drive only if you are alert as Nelova 200 mg Capsule may cause dizziness or visual disorders as side effects in some people. Nelova 200 mg Capsule may increase the risk of liver problems, especially in people with a history of liver problems. Therefore, if you have yellow skin and eyes, dark-coloured urine, or stomach pain while taking Nelova 200 mg Capsule , contact your doctor immediately, as these might be symptoms of liver problems. Inform your doctor if you have a severe problem with lactose (milk sugar) or other sugars as Nelova 200 mg Capsule may contain lactose. Most people who have mild or moderate lactose intolerance can take Nelova 200 mg Capsule . Avoid taking Nelova 200 mg Capsule if you have low levels of magnesium or potassium in the blood or long QTc syndrome. If you have had a surgical procedure involving the removal of the entire stomach (total gastrectomy), inform your doctor before taking Nelova 200 mg Capsule .
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Regular tests are recommended during treatment with Nelova 200 mg Capsule :
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