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Written By ,
Reviewed By Sunny S , MBBS
48 Hrs returnable
COD available

Online payment accepted

Not for online sale
rxMedicinePrescription drug

Whats That

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Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIDEPRESSANT

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - NEX0166

FAQs

NEXVENLA OD PLUS 50MG TABLET is a combination of two drugs: clonazepam and paroxetine. Clonazepam works by increasing levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Desvenlafaxine works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

When you start taking NEXVENLA OD PLUS 50MG TABLET, some patients might experience increased suicidal thoughts or actions. If you feel agitated or aggressive, visit your doctor. Also, do not miss any appointment with your doctor that is scheduled.

NEXVENLA OD PLUS 50MG TABLET causes weight gain due to increased appetite and mood changes. Eat a healthy diet and exercise regularly to maintain a healthy weight.

Do not discontinue NEXVENLA OD PLUS 50MG TABLET without consulting your doctor as it could lead to recurring symptoms. To treat your condition effectually, continue taking NEXVENLA OD PLUS 50MG TABLET for as long as prescribed. Moreover, stopping this medicine suddenly may result in withdrawal symptoms. Do not be reluctant to speak with your doctor if you feel any difficulty while taking NEXVENLA OD PLUS 50MG TABLET.

NEXVENLA OD PLUS 50MG TABLET may cause decreased sex-drive, problems with erection, and orgasm. Consult your doctor if you have any concerns regarding this.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid consumption of alcohol while taking NEXVENLA OD PLUS 50MG TABLET as it may cause an increased sedative effect.

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Pregnancy

Unsafe

NEXVENLA OD PLUS 50MG TABLET may cause toxic effects on the fetus. So, it is not recommended for pregnant women or planning to become pregnant. Consult your doctor for further advice.

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Breast Feeding

Caution

NEXVENLA OD PLUS 50MG TABLET should be used with caution in breastfeeding mothers. Your doctor may advise you to stop breastfeeding while taking this medication.

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Driving

Caution

Do not drive or operate heavy machinery as this me NEXVENLA OD PLUS 50MG TABLET may cause drowsiness.

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Liver

Caution

NEXVENLA OD PLUS 50MG TABLET should be used with caution in patients with severe liver impairment. Dose adjustments may be required in such cases.

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Kidney

Caution

NEXVENLA OD PLUS 50MG TABLET should be used with caution in patients with kidney problems. Dose adjustments may be required in such cases. Consult the doctor if you have concerns about using NEXVENLA OD PLUS 50MG TABLET in patients with kidney problems.

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Children

Caution

NEXVENLA OD PLUS 50MG TABLET should not be used in children unless prescribed by a child specialist.

About NEXVENLA OD PLUS 50MG TABLET

NEXVENLA OD PLUS 50MG TABLET belongs to a group of medicines called 'antidepressants'. It is used in the treatment of depression. Depression is a common mood disorder which negatively affects a person's daily life, described as feelings of sadness, loss, or anger. Depression symptoms can vary from mild to severe and include sadness, thoughts of death or suicide, loss of interest, weight loss or gain unrelated to dieting, trouble sleeping, loss of energy, feeling worthless or guilty, and difficulty thinking.

NEXVENLA OD PLUS 50MG TABLET is a combination of two drugs: clonazepam and desvenlafaxine. Clonazepam (benzodiazepine) works by increasing levels of a calming chemical, gamma-amino-butyric acid (GABA), in your brain. Desvenlafaxine (selective serotonin and norepinephrine reuptake inhibitors (SNRIs)) works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

Take NEXVENLA OD PLUS 50MG TABLET with or without food. The tablet form should be swallowed as a whole with a glass of water, do not chew or crush the tablet. In some cases, you may experience common side effects such as nausea, tiredness, constipation, confusion, insomnia (difficulty in sleeping), memory impairment, uncoordinated body movements, low sexual desire, depression, erectile dysfunction, and ejaculation disorder. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking NEXVENLA OD PLUS 50MG TABLET for as long as your doctor has prescribed. Do not take NEXVENLA OD PLUS 50MG TABLET if you are pregnant or breastfeeding unless specified by the doctor. NEXVENLA OD PLUS 50MG TABLET causes drowsiness, and sleepiness, do not drive unless you are alert. NEXVENLA OD PLUS 50MG TABLET should not be given to children and adolescents aged 18 years to treat depression. NEXVENLA OD PLUS 50MG TABLET is habit-forming so take it only if prescribed by a doctor. Avoid consuming alcohol with NEXVENLA OD PLUS 50MG TABLET as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of NEXVENLA OD PLUS 50MG TABLET

Depression (Mood Disorder)

Medicinal Benefits Mweb

Medicinal Benefits

NEXVENLA OD PLUS 50MG TABLET belongs to a group of medicines called 'antidepressants', containing clonazepam and desvenlafaxine. It is used in the treatment of depression. It improves mood, helps relieve anxiety and tension, and helps you sleep better. It also prevents extreme mood changes and increases your energy level, so you do not feel low. Clonazepam increases levels of a calming chemical, gamma-amino-butyric-acid (GABA), in your brain. Desvenlafaxine (selective serotonin and norepinephrine reuptake inhibitors (SNRIs)) works by increasing the levels of chemical messengers (serotonin and noradrenaline) in the brain that helps to maintain mental balance. Together, both of them help to elevate mood and treat depression.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of NEXVENLA OD PLUS 50MG TABLET

  • Headache
  • Nausea
  • Tiredness
  • Dry mouth
  • Constipation
  • Confusion
  • Insomnia (difficulty in sleeping)
  • Memory impairment
  • Ejaculation disorder
  • Difficulty in urination
  • Uncoordinated body movements
  • Depression
  • Erectile dysfunction
  • Low sexual desire

Drug Warnings

Do not take NEXVENLA OD PLUS 50MG TABLET if you are allergic to any ingredients present in it. Inform your doctor if you are taking antidepressants, antipsychotic medication, antihypertensives, or pain medication. Talk to your doctor if you have a history of seizures, bipolar disorder, suicide attempts, or schizophrenia. Patients with liver diseases, diabetes, heart disease, lung disease, and bleeding disorders should use NEXVENLA OD PLUS 50MG TABLET with caution. Please do not stop the treatment abruptly, as it can cause withdrawal reactions. NEXVENLA OD PLUS 50MG TABLET is not recommended for children and adolescents under 18 years of age as it increases suicidal tendencies in this population. NEXVENLA OD PLUS 50MG TABLET is habit-forming so take it only if prescribed by a doctor. Consult your doctor immediately if you experience suicidal thoughts like killing or harming yourself while on this medication. Do not take NEXVENLA OD PLUS 50MG TABLET if you are pregnant or breastfeeding unless prescribed. NEXVENLA OD PLUS 50MG TABLET causes drowsiness and dizziness, do not drive unless you are alert. Avoid consuming alcohol along with NEXVENLA OD PLUS 50MG TABLET as it could lead to increased drowsiness and dizziness.

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
DesvenlafaxineProcarbazine
Critical

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking Nexvenla Od Plus 50mg Tablet with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Nexvenla Od Plus 50mg Tablet and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineProcarbazine
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Combining Procarbazine and Nexvenla Od Plus 50mg Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and Nexvenla Od Plus 50mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with Nexvenla Od Plus 50mg Tablet and do not discontinue any medications without first consulting your doctor.
DesvenlafaxineSafinamide
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking Safinamide with Nexvenla Od Plus 50mg Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Nexvenla Od Plus 50mg Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Combining Isocarboxazid and Nexvenla Od Plus 50mg Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and Nexvenla Od Plus 50mg Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineTranylcypromine
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking tranylcypromine with Nexvenla Od Plus 50mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and Nexvenla Od Plus 50mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DesvenlafaxineRasagiline
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking rasagiline with Nexvenla Od Plus 50mg Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Nexvenla Od Plus 50mg Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
ClonazepamKetamine
Severe
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
When Nexvenla Od Plus 50mg Tablet and Ketamine are taken together, may increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Ketamine and Nexvenla Od Plus 50mg Tablet, but it can be taken if prescribed by a doctor. If you start feeling dizzy, tired, confused, have trouble focusing, feel very sleepy, or have trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
ClonazepamNalbuphine
Severe
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Co-administration of Nalbuphine with Nexvenla Od Plus 50mg Tablet can make the side effects worse.

How to manage the interaction:
Although there is a possible interaction between Nexvenla Od Plus 50mg Tablet and Nalbuphine, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling dizzy, having trouble breathing, or feeling very tired, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
ClonazepamDezocine
Severe
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Co-administration of Nexvenla Od Plus 50mg Tablet with Dezocine may increase the risk or severity of respiratory distress.

How to manage the interaction:
Although there is a possible interaction between Nexvenla Od Plus 50mg Tablet and Dezocine, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like feeling tired, dizzy, or having trouble focusing, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
ClonazepamMethadone
Severe
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Co-administration of Nexvenla Od Plus 50mg Tablet with methadone may cause serious side effects like respiratory depression (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Consult the doctor if you are taking Nexvenla Od Plus 50mg Tablet with methadone. Until you know how these medicines affect you, avoid driving or operating hazardous machinery as these medications may cause dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the dose and duration prescribed by your doctor. Do not discontinue the medication without a doctor's advice.

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Limit or avoid caffeine intake while taking desvenlafaxine and clonazepam as it increases the risk of side effects. Limit or avoid caffeine intake while being treated with desvenlafaxine and clonazepam.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • TRAMADOL
  • ASPIRIN
  • ACETAMINOPHEN
  • PETHIDINE
  • MORPHINE
  • CODEINE
  • PRAVASTATIN
  • PHENOBARBITAL
  • PHENYTOIN
  • SODIUM VALPROATE
  • CARBAMAZEPINE
  • ARIPIPRAZOLE
  • ESCITALOPRAM
  • METOPROLOL
  • CIMETIDINE

Habit Forming

Yes

Special Advise

  • NEXVENLA OD PLUS 50MG TABLET causes drowsiness. Avoid doing activities that require your complete focus and attention, like driving when on this drug.
  • An abrupt stoppage of NEXVENLA OD PLUS 50MG TABLET can lead to significant withdrawal symptoms. Always discuss with your doctor about decreasing the dosage before completely stopping its usage.
  • NEXVENLA OD PLUS 50MG TABLET is habit-forming so take it only if prescribed by a doctor.
  • Avoid consuming alcohol while on this medication, as it can lead to dangerous side effects.
  • NEXVENLA OD PLUS 50MG TABLET is unsafe for usage if you're pregnant or are planning to get pregnant. Discuss with your doctor about changing/replacing the medicine with safer alternatives.
  • To avoid getting addicted to this drug, take it in prescribed quantities and as directed by your doctor. Do not self-medicate.

Diet & Lifestyle Advise

  • Maintain a healthy and well-balanced diet. 
  • Do not take stress as it may aggravate your condition.
  • Limit alcohol intake and quit smoking.
  • Engage in social activities frequently as it may improve self-esteem and confidence. 
  • Limit caffeine intake.
  • Maintaining a healthy diet and exercising regularly helps improve overall health and boost self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables, and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help properly maintain neurotransmitters. 
  • Complex carbohydrates help stimulate serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps in the production of the body’s natural antidepressants. It also helps relieve stress, improve mood, boost self-esteem, and provide restful sleep.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

NEXVENLA OD PLUS 50MG TABLET Substitute

Substitutes safety advice
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    18.90per tablet
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