Novator F Tab
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Key Benefits
Novator F Tab taken with dietary measures helps in the treatment of high cholesterol and prevention of life-threatening conditions to the heart, especially for heart patients when initial dietary measures fail to lower cholesterol. It helps in lowering the bad cholesterol (LDL) and increases the level of good cholesterol (HDL) in the state of dyslipidemia or hyperlipidemia. Novator F Tab also lowers the amount of fat or cholesterol deposition (plaque) in the arteries of the heart thereby reducing the chance of having a heart attack or stroke in the future.
About Novator F Tab
Novator F Tab belongs to the class of medicines called antilipemic (lipid-lowering medicines) primarily used in the treatment of high lipid levels (cholesterol and triglycerides levels) and prevention of heart diseases and blood vessel blockage. Hyperlipidemia or hypertriglyceridemia is a condition in which there is a high level of low-density lipoproteins (LDL) or bad cholesterol and a decreased level of high-density lipoprotein (HDL) or good cholesterol. Increased level of bad cholesterol leads to a high risk of heart attack and stroke in the future, especially in patients with heart disease.
Novator F Tab is composed of two medicines, namely: Atorvastatin (HMG-CoA reductase inhibitor) and Fenofibrate (fibrates). Atorvastatin is a lipid-lowering medication that blocks the enzyme HMG-CoA reductase required to make cholesterol in the body. As a result, it lowers the bad cholesterol (low-density lipoproteins or LDL), and triglycerides (TG) and increases the levels of good cholesterol (high-density lipoproteins or HDL). Fenofibrate is another lipid-lowering agent which works by increasing the natural substance (lipoprotein lipase) that breaks down fats in the bloodstream thereby increasing its utilization and removal. As a result, it decreases harmful cholesterol like LDL (bad cholesterol), and triglycerides (TG) and increases levels of HDL (good cholesterol).
Take Novator F Tab as prescribed. Your doctor will advise how often you take Novator F Tab based on your medical condition. In some cases, you may experience allergic reactions, hyperglycemia (excess of glucose in the bloodstream), headache, blurred vision, stomach pain, constipation, headaches, joint swelling (edema), joint pain, muscle pain, back pain, slow heart rate, and nausea. Most of these side effects of Novator F Tab do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
If you are allergic to Novator F Tab or any component present in it namely atorvastatin or fenofibrate, please tell your doctor. If you are pregnant or breastfeeding, have hypothyroidism, drink more than 2 servings of alcohol per day, and have a muscle disorder (fibromyalgia) it is advised to inform your doctor before using Novator F Tab. Novator F Tab is not recommended for children below 12 years of age, as the safety and effectiveness were not established. If you experience yellowing of the skin (Jaundice), allergic reaction, cramps, or muscle weakness then immediately contact your doctor.
Drug-Drug Interactions
Drug-Drug Interactions
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Taking Novator F Tab with Posaconazole can increase the blood levels of Novator F Tab. This can increase the risk of side effects.
How to manage the interaction:
Although there is an interaction between posaconazole with Novator F Tab, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Coadministration of Nicotinamide with Novator F Tab can increase the risk and severity of side effects like rhabdomyolysis (breakdown of skeletal muscle) or kidney damage.
How to manage the interaction:
Taking Nicotinamide with Novator F Tab together is used with caution as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Using Novator F Tab together with telithromycin may significantly increase the blood levels of Novator F Tab.
How to manage the interaction:
Taking Telithromycin with Novator F Tab together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
Using Novator F Tab together with nefazodone may significantly increase the blood levels of Novator F Tab.
How to manage the interaction:
Taking Novator F Tab with Nefazodone together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
Taking Novator F Tab with indinavir may considerably raise Novator F Tab levels in the blood.
How to manage the interaction:
Taking Novator F Tab and indinavir together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
Using Novator F Tab together with troleandomycin may significantly increase the blood levels of Novator F Tab.
How to manage the interaction:
Taking Novator F Tab with Troleandomycin together can result in an interaction, but it can be taken if a doctor has advised it. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
Coadministration of Erlotinib with Novator F Tab can raise the chance of side effects (liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).
How to manage the interaction:
Taking Erlotinib with Novator F Tab together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unexplained muscle pain, muscle stiffness or tenderness, fever, dark-colored urine, or weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Using Novator F Tab together with itraconazole may significantly increase the blood levels of Novator F Tab.
How to manage the interaction:
Coadministration of Novator F Tab along with itraconazole together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not discontinue any medication without consulting a doctor.
Using Novator F Tab together with fosamprenavir may significantly increase the blood levels of Novator F Tab.
How to manage the interaction:
Although there is a possible interaction between Novator F Tab and Fosamprenavir, you can take these medicines together if prescribed by a doctor. You should seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
Taking Novator F Tab with nelfinavir may considerably raise Novator F Tab levels in the blood. This can raise the chance of side effects (liver injury and rhabdomyolysis - an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury).
How to manage the interaction:
Although taking Novator F Tab and cyclosporine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor. Do not stop using any medications without talking to a doctor.
Drug-Food Interactions
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Grapefruit Juice
How to manage the interaction:
Blood levels of atorvastatin can rise after consuming grapefruit juice. Before quitting the drug, speak to a doctor even though there may be an interaction. Additionally, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, or yellowing of the skin or eyes, you should consult a doctor. Without first consulting your doctor, never stop taking the medication.
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Reference
- https://www.ncbi.nlm.nih.gov/books/NBK430779/\
- https://www.webmd.com/drugs/2/drug-841/atorvastatin-oral/details
- https://www.medicines.org.uk/emc/files/pil.4339.pdf
- https://pubmed.ncbi.nlm.nih.gov/21675801/
- https://www.medicines.org.uk/emc/files/pil.5779.pdf
- https://www.mims.com/india/drug/info/atorvastatin?type=full&mtype=generic
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