CLOMIPHENE-50MGOther abnormal uterine and vaginal bleeding
How does the disease interact with O Fert 50mg Tablet:
Abnormal uterine bleeding:
In patients who are not diagnosed with abnormal genital bleeding, O Fert 50mg Tablet is contraindicated. Evaluate the patients for the presence of neoplastic lesions.
How to manage the interaction:
The use of O Fert 50mg Tablet is contraindicated in patients with undiagnosed, abnormal genital bleeding.
CLOMIPHENE-50MGHepatic failure, not elsewhere classified
How does the disease interact with O Fert 50mg Tablet:
Hepatic dysfunction:
O Fert 50mg Tablet is contraindicated for patients who have liver failure or a past history of hepatic dysfunction. The O Fert 50mg Tablet is primarily metabolized in the liver and enters into enterohepatic circulation. Thus, there will be increase in serum concentration and half-life of O Fert 50mg Tablet.
How to manage the interaction:
The use of O Fert 50mg Tablet is contraindicated in patients with liver disease or history of hepatic dysfunction.
CLOMIPHENE-50MGDisorders of endocrine glands in diseases classified elsewhere
How does the disease interact with O Fert 50mg Tablet:
Pituitary activity:
O Fert 50mg Tablet is contraindicated for patients who have uncontrolled thyroid or adrenal dysfunction, or who have an organic intracranial lesion such as a pituitary tumour. O Fert 50mg Tablet interacts with oestrogen receptors in several tissues, including the pituitary, causing a rise in pituitary gonadotropin secretion.
How to manage the interaction:
O Fert 50mg Tablet is contraindicated in patients with uncontrolled thyroid, adrenal dysfunction or pituitary tumour.
CLOMIPHENE-50MGOther disorders of adrenal gland
How does the disease interact with O Fert 50mg Tablet:
Uncontrolled adrenal dysfunction :
O Fert 50mg Tablet is contraindicated in patients with uncontrolled adrenal function. Adrenal dysfunction can make pregnancy difficult. O Fert 50mg Tablet therapy may cause changes in steroid production and/or fluid balance.
How to manage the interaction:
The use of O Fert 50mg Tablet is contraindicated in patients with uncontrolled adrenal function.
CLOMIPHENE-50MGDisorders of lipoprotein metabolism and other lipidaemias
How does the disease interact with O Fert 50mg Tablet:
Hyperlipidemia:
Some patients who are on O Fert 50mg Tablet therapy have reported hypertriglyceridemia. Preexisting hyperlipidemia or a family history of hyperlipidemia, Higher doses of O Fert 50mg Tablet for a long period are related to an increased risk of hypertriglyceridemia. In this conditions, Monitor plasma triglycerides regular basis and also at base line before initiating the therapy with O Fert 50mg Tablet.
How to manage the interaction:
Hypertriglyceridemia may occur during O Fert 50mg Tablet therapy, especially in patients with a family history of hyperlipidemia and use of higher than the recommended dose and/or longer duration of treatment. Periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia. Pretreatment screening of triglyceride levels is advised in patients initiating O Fert 50mg Tablet therapy.