CLOMIPHENE-50MGOther abnormal uterine and vaginal bleeding
How does the disease interact with Pifert 50mg Tablet:
Abnormal uterine bleeding:
In patients who are not diagnosed with abnormal genital bleeding, Pifert 50mg Tablet is contraindicated. Evaluate the patients for the presence of neoplastic lesions.
How to manage the interaction:
The use of Pifert 50mg Tablet is contraindicated in patients with undiagnosed, abnormal genital bleeding.
CLOMIPHENE-50MGHepatic failure, not elsewhere classified
How does the disease interact with Pifert 50mg Tablet:
Hepatic dysfunction:
Pifert 50mg Tablet is contraindicated for patients who have liver failure or a past history of hepatic dysfunction. The Pifert 50mg Tablet is primarily metabolized in the liver and enters into enterohepatic circulation. Thus, there will be increase in serum concentration and half-life of Pifert 50mg Tablet.
How to manage the interaction:
The use of Pifert 50mg Tablet is contraindicated in patients with liver disease or history of hepatic dysfunction.
CLOMIPHENE-50MGDisorders of endocrine glands in diseases classified elsewhere
How does the disease interact with Pifert 50mg Tablet:
Pituitary activity:
Pifert 50mg Tablet is contraindicated for patients who have uncontrolled thyroid or adrenal dysfunction, or who have an organic intracranial lesion such as a pituitary tumour. Pifert 50mg Tablet interacts with oestrogen receptors in several tissues, including the pituitary, causing a rise in pituitary gonadotropin secretion.
How to manage the interaction:
Pifert 50mg Tablet is contraindicated in patients with uncontrolled thyroid, adrenal dysfunction or pituitary tumour.
CLOMIPHENE-50MGOther disorders of adrenal gland
How does the disease interact with Pifert 50mg Tablet:
Uncontrolled adrenal dysfunction :
Pifert 50mg Tablet is contraindicated in patients with uncontrolled adrenal function. Adrenal dysfunction can make pregnancy difficult. Pifert 50mg Tablet therapy may cause changes in steroid production and/or fluid balance.
How to manage the interaction:
The use of Pifert 50mg Tablet is contraindicated in patients with uncontrolled adrenal function.
CLOMIPHENE-50MGDisorders of lipoprotein metabolism and other lipidaemias
How does the disease interact with Pifert 50mg Tablet:
Hyperlipidemia:
Some patients who are on Pifert 50mg Tablet therapy have reported hypertriglyceridemia. Preexisting hyperlipidemia or a family history of hyperlipidemia, Higher doses of Pifert 50mg Tablet for a long period are related to an increased risk of hypertriglyceridemia. In this conditions, Monitor plasma triglycerides regular basis and also at base line before initiating the therapy with Pifert 50mg Tablet.
How to manage the interaction:
Hypertriglyceridemia may occur during Pifert 50mg Tablet therapy, especially in patients with a family history of hyperlipidemia and use of higher than the recommended dose and/or longer duration of treatment. Periodic monitoring of plasma triglycerides is recommended in patients with preexisting or family history of hyperlipidemia. Pretreatment screening of triglyceride levels is advised in patients initiating Pifert 50mg Tablet therapy.