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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

PIRFENIDONE-400MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

MISCELLANEOUS

Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - PIR0143

Author Details

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FAQs

Pirfemac 400mg Tablet helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Pirfemac 400mg Tablet might make you photosensitive (sensitivity to sunlight). Avoid exposure to sunlight and sunlamps. Wear SPF 50+ sunscreen and protective clothing to reduce exposure to sunlight. Talk to your doctor if you are taking any medicines known to cause photosensitivity. If you notice any symptoms of photosensitivity, consult a doctor.

Do not discontinue Pirfemac 400mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Pirfemac 400mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Pirfemac 400mg Tablet .

Diarrhoea might be a side-effect of Pirfemac 400mg Tablet . Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

No, avoid smoking prior to the start of the treatment and while taking Pirfemac 400mg Tablet as smoking might alter the effectiveness of Pirfemac 400mg Tablet .

Weight loss could occur due to loss of appetite. Maintain proper weight by eating healthy food. Your doctor might monitor your weight whilst taking Pirfemac 400mg Tablet . Consult your doctor if you notice severe weight loss.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

It is not known if alcohol interacts with Pirfemac 400mg Tablet . However, avoid consumption of alcohol while taking Pirfemac 400mg Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding; your doctor will decide whether Pirfemac 400mg Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Pirfemac 400mg Tablet might cause dizziness and tiredness. Drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this. Pirfemac 400mg Tablet is not recommended for patients with severe hepatic impairment.

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns. Pirfemac 400mg Tablet is not recommended for patients with an end-stage renal disease requiring dialysis.

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Children

Unsafe

Pirfemac 400mg Tablet is not recommended for children below 18years as the safety and effectiveness has not been established.

About Pirfemac 400mg Tablet

Pirfemac 400mg Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease that is marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, due to which it gets difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.
 
Pirfemac 400mg Tablet contains ‘Pirfenidone’, which helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Pirfemac 400mg Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis. 

In some cases, you may experience certain common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Pirfemac 400mg Tablet if you are pregnant or breastfeeding. Pirfemac 400mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Pirfemac 400mg Tablet as it could lead to increased dizziness. Pirfemac 400mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Pirfemac 400mg Tablet

Idiopathic pulmonary fibrosis

Medicinal Benefits Mweb

Medicinal Benefits

Pirfemac 400mg Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Pirfemac 400mg Tablet can help effectively slow the rate of lung function decline by 50%. Pirfemac 400mg Tablet helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Pirfemac 400mg Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis.

Directions for Use

Take Pirfemac 400mg Tablet with food. Swallow Pirfemac 400mg Tablet as a whole with a glass of water; do not chew or crush it.

Side Effects of Pirfemac 400mg Tablet

  • Nausea
  • Tiredness
  • Diarrhoea
  • Indigestion/Stomach upset
  • Loss of appetite
  • Headache
  • Photosensitivity

Drug Warnings

Do not take Pirfemac 400mg Tablet if you are allergic to any of its components; if you have a severe or end-stage liver impairment or kidney disease requiring dialysis; if you are taking fluvoxamine (anti-depressant). Inform your doctor if you are taking any medicines that might make you photosensitive, if you smoke or have kidney or liver problems. Consult your doctor before taking Pirfemac 400mg Tablet if you are pregnant or breastfeeding. Pirfemac 400mg Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Pirfemac 400mg Tablet as it could lead to increased dizziness. Pirfemac 400mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Pirfemac 400 Tablet:
When Pirfemac 400 Tablet is taken with Phenobarbital, it can decrease the effects of Pirfemac 400 Tablet.

How to manage the interaction:
Taking Pirfemac 400 Tablet with Phenobarbital is not recommended but can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Pirfemac 400 Tablet:
Taking Pirfemac 400 Tablet with rifampicin can reduce the levels and effects of Pirfemac 400 Tablet

How to manage the interaction:
Although there is an interaction between Pirfemac 400 Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pirfemac 400 Tablet:
Taking Pirfemac 400 Tablet with Carbamazepine it reduces the levels and effects of Pirfemac 400 Tablet.

How to manage the interaction:
Taking Pirfemac 400 Tablet with Carbamazepine is not recommended but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pirfemac 400 Tablet:
Coadministration of Pirfemac 400 Tablet with primidone can reduce levels and the effects of Pirfemac 400 Tablet.

How to manage the interaction:
Although there is an interaction between Pirfemac 400 Tablet and primidone, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pirfemac 400 Tablet:
Co-administration of Amiodarone and Pirfemac 400 Tablet may raise the risk of liver issues.

How to manage the interaction:
Even though Amiodarone and Pirfemac 400 Tablet interact, they can be used if a doctor prescribes them. Seek medical attention if you have a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, lack of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes. Do not stop taking any medications without visiting a doctor.
PirfenidoneEnoxacin
Severe
How does the drug interact with Pirfemac 400 Tablet:
When Enoxacin is taken with Pirfemac 400 Tablet, it can increase the levels of Pirfemac 400 Tablet, which may lead to side effects.

How to manage the interaction:
Although taking Pirfemac 400 Tablet and Enoxacin together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pirfemac 400 Tablet:
When ciprofloxacin is taken Pirfemac 400 Tablet, the blood levels of Pirfemac 400 Tablet may increase, which may lead to side effects.

How to manage the interaction:
Although taking ciprofloxacin and Pirfemac 400 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you have any of the following symptoms, fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medications without a doctor's advice.
PirfenidoneLomitapide
Severe
How does the drug interact with Pirfemac 400 Tablet:
Taking Lomitapide with Pirfemac 400 Tablet may increase the risk of liver damage

How to manage the interaction:
There may be a possibility of interaction between Pirfemac 400 Tablet and Lomitapide, but it can be taken if prescribed by a doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
PirfenidoneAminolevulinic acid
Severe
How does the drug interact with Pirfemac 400 Tablet:
Co-administration of Aminolevulinic acid and Pirfemac 400 Tablet may increase the risk of skin burn.

How to manage the interaction:
There may be a possibility of interaction between Pirfemac 400 Tablet and Aminolevulinic acid, but it can be taken if prescribed by a doctor. Avoid exposure of the eyes and skin to sunlight or bright indoor lights for 48 hours after treatment. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pirfemac 400 Tablet:
Taking Pirfemac 400 Tablet with Rucaparib can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Co-administration of Pirfemac 400 Tablet with Rucaparib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.

Drug-Food Interactions

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PIRFENIDONE-400MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PIRFENIDONE-400MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit and its products while using Pirfemac 400 Tablet can increase the risk of side effects. Avoid grape fruit and its products during treatment with Pirfemac 400 Tablet.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • FLUVOXAMINE
  • CIPROFLOXACIN
  • ENOXACIN
  • RIFAMPICIN
  • AMIODARONE
  • PROPAFENONE
  • OMEPRAZOLE

Habit Forming

No

Special Advise

  • Your doctor may advise liver function tests prior to the start of the treatment.
  • Regular blood tests are advised at the start of treatment with Pirfemac 400mg Tablet and monthly for every 6 months, and then for every 3 months thereafter to check the liver functioning.

Diet & Lifestyle Advise

  • Watch out for triggers that make the cough worse, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow the pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and fruit juices.
  • Avoid processed and refined foods.

Pirfemac 400mg Tablet Substitute

Always consult your doctor before taking any new medications and supplements

  • Pirfenex 400 mg Tablet 15's

    by AYUR

    42.30per tablet
  • Fibrodone 400 Tablet 10's

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    36.59per tablet
  • Prifedon 400 Tablet 15's

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    45.10per tablet

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