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  1. Home
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  3. Pyranij-500 Tablet 10's

Not for online sale
Pyranij-500 Tablet 10's, Pack of 10 ORAL SUSPENSIONS
Written By Divya L , PharmaD
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
48 Hrs returnable
Know More
COD available

Online payment accepted

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Whats That

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Composition :

PYRAZINAMIDE-500MG

Manufacturer/Marketer :

Sunij Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

Therapeutic Class

ANTI- TUBERCULOSIS

Country of origin

India

Manufacturer/Marketer address

T-1/B National Park, Gulbai Tekra, Ahmedabad 380 015, (India)
Other Info - PYR0218

Author Details

Doctor image

Written By

Divya L

PharmaD

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 8, 2025 | 9:34 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Pyranij-500 Tablet contains 'Pyrazinamide.' It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacteria that causes tuberculosis.

Pyranij-500 Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Pyranij-500 Tablet .

Pyranij-500 Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Pyranij-500 Tablet if you are undergoing any vaccinations.

It is advised to take Pyranij-500 Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.

Pyranij-500 Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Pyranij-500 Tablet should be avoided if you have a history of gout.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Pyranij-500 Tablet . Alcohol intake, along with Pyranij-500 Tablet , may cause increased liver damage. Please consult your doctor for more information.

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Pregnancy

Caution

Pyranij-500 Tablet should be used with caution during pregnancy. Please consult your doctor before taking Pyranij-500 Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Pyranij-500 Tablet is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

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Driving

Caution

It is not known if Pyranij-500 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

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Liver

Caution

Pyranij-500 Tablet is not recommended in patients with severe liver damage. Please consult your doctor since Pyranij-500 Tablet should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

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Kidney

Caution

Please consult your doctor since Pyranij-500 Tablet should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

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Children

Caution

Pyranij-500 Tablet is recommended in children below 12 years of age only after doctor's advice.

Product Substitutes

Reference

  1. https://www.drugs.com/mtm/pyrazinamide.html
  2. https://www.webmd.com/drugs/2/drug-7398/pyrazinamide-oral/details
  3. https://www.medicines.org.uk/emc/files/pil.5273.pdf

About Pyranij-500 Tablet

Pyranij-500 Tablet belongs to the group of medicines called 'anti-tuberculosis' drugs primarily used to treat and prevent tuberculosis. Tuberculosis is an infectious disease that mainly affects the lungs, but it can also spread to other body parts such as kidneys, brain, spine and bone marrow. Pyranij-500 Tablet does not work against infections caused by the virus, such as the common cold and flu.

Pyranij-500 Tablet contains 'Pyrazinamide'. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria.

Your doctor will decide the dose and duration based on the severity of your disease. Common side effects of Pyranij-500 Tablet include muscle/joint pain, nausea, vomiting and loss of appetite. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Let your doctor know if you use any prescription and non-prescription medications you are taking, including other vitamins, before starting Pyranij-500 Tablet . Please tell your doctor if you are allergic to Pyranij-500 Tablet or its components. Inform your doctor beforehand if you have a history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and are undergoing dialysis. It is essential to let your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother. Avoid consuming alcohol along with Pyranij-500 Tablet as it might lead to liver problems.

Uses of Pyranij-500 Tablet

Tuberculosis (TB).

Medicinal Benefits Mweb

Medicinal Benefits

Pyranij-500 Tablet contains 'Pyrazinamide', which is used to treat and prevent tuberculosis. Pyrazinamide is a chemically synthesised bacteriocidal antibiotic. It converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary to survive the TB bacteria. It is usually given in alone or combined with other antitubercular agents to treat tuberculosis.

Directions for Use

Swallow Pyranij-500 Tablet as a whole with water; do not crush, break or chew it.

Side Effects of Pyranij-500 Tablet

  • Muscle/joint pain
  • Nausea
  • Vomiting
  • Loss of appetite
  • Hepatitis, liver dysfunction

Drug Warnings

Brief your medical history to the doctor if you have any liver or kidney diseases, diabetes, gout, high uric acid level in the blood, lactose intolerance, alcohol use and are undergoing dialysis treatment before starting Pyranij-500 Tablet . Let your doctor know if you are undergoing any vaccinations with live bacterial vaccines (like typhoid vaccine) since Pyranij-500 Tablet may affect vaccine's activity. Please consult your doctor know if you are pregnant, planning to conceive or are a breastfeeding mother before starting Pyranij-500 Tablet . Avoid consuming alcohol along with Pyranij-500 Tablet as it might lead to liver problems. Store Pyranij-500 Tablet below 25°C away from direct sunlight.

Drug-Drug Interactions

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PyrazinamideLeflunomide
Severe
PyrazinamideKetoconazole
Severe

Drug-Drug Interactions

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PyrazinamideLeflunomide
Severe
How does the drug interact with Pyranij-500 Tablet:
Co-administration of leflunomide with Pyranij-500 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunomide and Pyranij-500 Tablet together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PyrazinamideKetoconazole
Severe
How does the drug interact with Pyranij-500 Tablet:
Co-administration of Ketoconazole with Pyranij-500 Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Pyranij-500 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
PyrazinamideTeriflunomide
Severe
How does the drug interact with Pyranij-500 Tablet:
Co-administration of Teriflunomide with Pyranij-500 Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Teriflunomide and Pyranij-500 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
PyrazinamideRifampicin
Severe
How does the drug interact with Pyranij-500 Tablet:
Taking rifampicin together with Pyranij-500 Tablet can cause liver problems.

How to manage the interaction:
Although there is an interaction between Pyranij-500 Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience fever, rash, less desire to eat, nausea, vomiting, fatigue, right upper abdominal pain, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PyrazinamideLomitapide
Severe
How does the drug interact with Pyranij-500 Tablet:
Co-administration of Lomitapide with Pyranij-500 Tablet may increase in the risk or severity of liver problems.

How to manage the interaction:
Although taking Lomitapide and Pyranij-500 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • PROBENECID
  • SULFINPYRAZONE

Habit Forming

No

Special Advise

  • Let your doctor know that you are taking Pyranij-500 Tablet if you are undergoing any medical tests.
  • Your doctor may advise liver enzymes and uric acid levels tests before you start treatment to make sure you can safely take Pyranij-500 Tablet .
  • It is advised to undergo liver functioning tests to keep a check on your liver function.
  • Use a reliable contraceptive method (such as condoms or a diaphragm) to prevent pregnancy while you are taking Pyranij-500 Tablet as it may make hormonal contraceptives such as the pill less effective.

Diet & Lifestyle Advise

  • Pineapple juice might help soothe the symptoms of cough and cold. It also has anti-inflammatory and mucolytic properties.
  • Foods rich in vitamin C, such as kiwi, broccoli and bell pepper, help improve the immune system.
  • Avoid processed and fried foods.
  • Warm ginger tea or warm soup can help in providing relief from the cough.
  • Avoid foods and drinks, such as cured meat, matured cheese, soya, tuna, salmon, mackerel, wine and beer.
  • Quit smoking and avoid alcohol consumption.

Pyranij-500 Tablet Substitute

Substitutes safety advice

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