Ratapenem 1gm Injection

How does the drug interact with Ratapenem 1gm Injection:
Coadministration of Ratapenem 1gm Injection with Divalproex may reduce the blood levels of Divalproex and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, Ratapenem 1gm Injection can be taken with Divalproex if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.

How does the drug interact with Ratapenem 1gm Injection:
Co-administration of Metrizamide and Ratapenem 1gm Injection may increase the risk or severity of seizures.

How to manage the interaction:
Co-administration of Ratapenem 1gm Injection and Metrizamide can lead to an interaction, it can be taken if advised by a doctor. However, if you are elderly, undergoing alcohol or drug withdrawal, have a history of seizures, or have a condition affecting the central nervous system such as a brain tumor or head trauma, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

How does the drug interact with Ratapenem 1gm Injection:
Co-administration of Iomeprol and Ratapenem 1gm Injection may increase the risk or severity of seizures.

How to manage the interaction:
Co-administration of Ratapenem 1gm Injection and Iomeprol can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.

How does the drug interact with Ratapenem 1gm Injection:
Co-administration of Bupropion may rarely cause seizures and combining it with Ratapenem 1gm Injection may increase that risk.

How to manage the interaction:
Although there is a possible interaction, Ratapenem 1gm Injection can be taken with bupropion if prescribed by the doctor. Do not discontinue the medications without consulting a doctor.

How does the drug interact with Ratapenem 1gm Injection:
When BCG vaccine is used with Ratapenem 1gm Injection, its effectiveness may be reduced.

How to manage the interaction:
Although there is a possible interaction between Ratapenem 1gm Injection and BCG vaccine, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.

How does the drug interact with Ratapenem 1gm Injection:
The combined use of tramadol with Ratapenem 1gm Injection can make tramadol less effective as a treatment.

How to manage the interaction:
Taking Ratapenem 1gm Injection with tramadol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

How does the drug interact with Ratapenem 1gm Injection:
The combined use of Ratapenem 1gm Injection and sodium valproate can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ratapenem 1gm Injection and sodium valproate can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.

How does the disease interact with Ratapenem 1gm Injection:
Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy.

How to manage the interaction:
Clostridioides difficile-associated diarrhea (CDAD) has been reported with anti-bacterial agents. Therapy should be administered cautiously in patients with history of gastrointestinal disease, particularly colitis; pseudomembranous colitis.

How does the disease interact with Ratapenem 1gm Injection:
The kidney is the main organ used to remove carbapenems. Due to slower medication clearance, patients with renal impairment may be more susceptible to carbapenem side effects, such as seizures and other CNS abnormalities. According to the specific product package labelling, dosage variations should be taken into account and be based on the severity of the illness and the degree of renal impairment. Periodic renal function tests should be carried out while receiving treatment.

How to manage the interaction:
Dose adjustment may be needed in patients with kidney problems. Renal function tests should be performed periodically during therapy.

How does the disease interact with Ratapenem 1gm Injection:
The intravenous use of carbapenems has been linked to deleterious effects on the central nervous system, including hallucinations, somnolence, encephalopathy, myoclonus, tremor, paresthesia, disorientation, agitation, and seizures (up to 1.5%). Regardless of the method of administration, carbapenem therapy should be used with caution in patients who have seizures or other neurologic abnormalities or are at high risk for developing them. In these people, the usual dosage recommendations shouldn't be exceeded. Anticonvulsant medication should be continued in patients with a known seizure disorder while receiving carbapenem medication.

How to manage the interaction:
Therapy should be administered cautiously in patients with or predisposed to seizures or other neurologic disturbances.

How does the disease interact with Ratapenem 1gm Injection:
Hemodialysis helps to partially eliminate Ratapenem 1gm Injection. A supplement dose of 150 mg is advised to be taken after the dialysis session if the 500 mg daily dose is taken within 6 hours of the procedure. When administered at least 6 hours before hemodialysis, an additional dose is not required.

How to manage the interaction:
Dose adjustment may be needed in patients undergoing dialysis.