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Written By Sureshvarma D , MPharma
48 Hrs returnable
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Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CARDIOVASCULAR AGENTS

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - SAC0129

FAQs

Sacu-V 50 Tablet is a combination of Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Sacu-V 50 Tablet helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.

Please do not stop taking Sacu-V 50 Tablet without consulting your doctor on your own as it may lead to rising in blood pressure. Continue taking Sacu-V 50 Tablet for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Sacu-V 50 Tablet .

Orthostatic hypotension could be a side-effect of Sacu-V 50 Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better. People taking Sacu-V 50 Tablet are advised to monitor their blood pressure levels to avoid unpleasant events regularly.

High blood pressure increases the workload on the arteries and heart. If untreated, it could damage the heart, brain, and kidney's blood vessels, resulting in a stroke, heart failure, or kidney failure. Hypertension increases the risk of heart attacks.

Talk to your doctor before taking potassium supplements, potassium-sparing diuretics, or salt substitutes along with Sacu-V 50 Tablet as it might cause an increase in serum potassium and serum creatinine levels.

Sacu-V 50 Tablet may cause a headache as a common side effect, especially in the first few days of treatment. However, if the condition persists or worsens, please consult a doctor to reduce the dose initially.

Sacu-V 50 Tablet is not recommended for patients with severe hypotension (low blood pressure) as it may increase the risk of worsening the condition. Therefore, inform your doctor if you have low blood pressure before taking Sacu-V 50 Tablet .

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Sacu-V 50 Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

It is not recommended to take Sacu-V 50 Tablet while you are pregnant. Please consult your doctor. Your doctor will decide whether Sacu-V 50 Tablet can be given to pregnant women or not.

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Breast Feeding

Unsafe

It is not recommended to take Sacu-V 50 Tablet while you are breast-feeding. Please consult your doctor. Your doctor will decide whether Sacu-V 50 Tablet can be given to breast-feeding mothers or not.

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Driving

Caution

Sacu-V 50 Tablet may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Dose adjustment may be needed. Sacu-V 50 Tablet should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Dose adjustment may be needed. Sacu-V 50 Tablet should be used with caution in patients with kidney impairment/kidney disease.

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Children

Unsafe

Sacu-V 50 Tablet can be used to treat heart failure in children who are at least 1 year old when prescribed by a child specialist

About Sacu-V 50 Tablet

Sacu-V 50 Tablet belongs to a class of cardiovascular agents that is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.

Sacu-V 50 Tablet is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Together, Sacu-V 50 Tablet helps in the treatment of heart failure.

Take Sacu-V 50 Tablet with or without food or as directed by your doctor. Do not crush, chew or break the tablet, swallow it as a whole with a glass of water. You are advised to take Sacu-V 50 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as cough, dizziness, nausea, diarrhea, weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Sacu-V 50 Tablet for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain, or heart attack.  Do not be reluctant to speak with your doctor if you experience any difficulty while taking Sacu-V 50 Tablet . Do not take Sacu-V 50 Tablet with ACE inhibitors (such as captopril, enalapril) since the risk of side effects may increase. Do not take Sacu-V 50 Tablet for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking Sacu-V 50 Tablet if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).

Uses of Sacu-V 50 Tablet

Heart failure.

Medicinal Benefits Mweb

Medicinal Benefits

Sacu-V 50 Tablet is a combination of two medicines Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Sacu-V 50 Tablet helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.

Directions for Use

Tablet: Swallow it as a whole with water; do not crush, break or chew it.Suspension: Shake the suspension bottle well before use. Check the label for directions and take it with or without food with a measuring cup in the dose and duration prescribed by the doctor.

Side Effects of Sacu-V 50 Tablet

  • Cough
  • Dizziness
  • Diarrhea
  • Fainting
  • Headache
  • Nausea
  • Stomach pain
  • Vertigo (sensation of feeling off-balance)
  • Weakness

Drug Warnings

Keep your doctor informed if you have kidney or liver diseases. Discuss with your doctor if you are taking any other medicines along with Sacu-V 50 Tablet . Avoid smoking and alcohol consumption. Pregnant women and breastfeeding women should consult their doctor before taking Sacu-V 50 Tablet . A prolonged intake of Sacu-V 50 Tablet can cause an altered potassium level so, regular monitoring of potassium is required. Driving and operating heavy machinery should not be done as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur, so patients using Sacu-V 50 Tablet should get up with caution. Speak to your doctor if you have diabetes before taking Sacu-V 50 Tablet . Inform your doctor about your current medicines such as aliskiren (medication to treat high blood pressure), any other heart or blood pressure medicines, lithium, mineral supplements that contain potassium. Inform your doctor if you feel light-headed or have little or no urination, rapid weight gain, swelling in your hands, feet, or ankles after taking Sacu-V 50 Tablet .

Drug-Drug Interactions

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ValsartanAliskiren
Critical
ValsartanRamipril
Severe

Drug-Drug Interactions

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ValsartanAliskiren
Critical
How does the drug interact with Sacu-V 50 Tablet:
Using Aliskiren together with Sacu-V 50 Tablet may increase the risk of serious side effects (kidney problems, low blood pressure, or high potassium levels).

How to manage the interaction:
Taking Sacu-V 50 Tablet with Aliskiren is not advised as it can result in an interaction, it can be taken if a doctor has advised it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
ValsartanRamipril
Severe
How does the drug interact with Sacu-V 50 Tablet:
Taking Ramipril with Sacu-V 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Ramipril together with Sacu-V 50 Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. Do not stop taking any medication without consulting a doctor.
ValsartanSpironolactone
Severe
How does the drug interact with Sacu-V 50 Tablet:
Using spironolactone together with Sacu-V 50 Tablet may increase potassium levels in the blood.

How to manage the interaction:
Although taking spironolactone and Sacu-V 50 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without consulting a doctor.
ValsartanFosinopril
Severe
How does the drug interact with Sacu-V 50 Tablet:
Coadministration of Fosinopril and Sacu-V 50 Tablet can increase the risk or severity of side effects (kidney problems, low blood pressure or high potassium levels in the body).

How to manage the interaction:
Although taking Fosinopril together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanLisinopril
Severe
How does the drug interact with Sacu-V 50 Tablet:
Coadministration of Lisinopril and Sacu-V 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Lisinopril together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanTrimethoprim
Severe
How does the drug interact with Sacu-V 50 Tablet:
Using trimethoprim together with Sacu-V 50 Tablet may increase potassium levels in the blood.

How to manage the interaction:
Although taking Trimethoprim together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medication without consulting a doctor.
ValsartanEnalapril
Severe
How does the drug interact with Sacu-V 50 Tablet:
Combine use of Enalapril and Sacu-V 50 Tablet can increase the effect of Sacu-V 50 Tablet.

How to manage the interaction:
Although taking Enalapril together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanPerindopril
Severe
How does the drug interact with Sacu-V 50 Tablet:
Coadministration of Perindopril with Sacu-V 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Perindopril together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience symptoms such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat, contact a doctor. Do not discontinue any medication without consulting a doctor.
ValsartanPotassium chloride
Severe
How does the drug interact with Sacu-V 50 Tablet:
Co-administration of Potassium chloride with Sacu-V 50 Tablet may increase the risk of side effects (low blood pressure, kidney function impairment, and hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Potassium chloride together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
ValsartanLithium
Severe
How does the drug interact with Sacu-V 50 Tablet:
Coadministration of Lithium and Sacu-V 50 Tablet increase the blood levels of lithium.

How to manage the interaction:
Although taking Lithium together with Sacu-V 50 Tablet may result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination, contact a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods
Moderate

Drug-Food Interactions

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SACUBITRIL-24MG+VALSARTAN-26MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Co-administration of Sacu-V 50 Tablet along with moderate-to-high dietary potassium intake, especially salt substitutes may lead to high potassium levels in the blood. Avoid taking potassium-containing salt substitutes or over-the-counter potassium supplements along with Sacu-V 50 Tablet as this can lead to high potassium levels in blood. However, if you experience weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs, consult a doctor.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • ATORVASTATIN
  • INSULIN DETEMIR
  • METOPROLOL
  • BUDESONIDE
  • FORMOTEROL

Habit Forming

No

Special Advise

  • Regularly monitor blood pressure levels to prevent hypotension (low blood pressure).
  • Get up slowly while rising from a lying or sitting position as Sacu-V 50 Tablet may cause dizziness.
  • Keep your doctor informed about your health/disease conditions and the medicines you are taking.

Diet & Lifestyle Advise

  • You are advised to consume low salt and low-fat diet while taking Sacu-V 50 Tablet .
  • Regular exercise is also recommended to complement treatment with Sacu-V 50 Tablet .
  • Eat a diet rich in whole grains, vegetables, fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, massage would also help in treating high blood pressure.

Sacu-V 50 Tablet Substitute

Substitutes safety advice
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