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Alcohol
Caution
It is unknown whether Secef 400 mg Capsule interacts with alcohol. However, as a precautionary measure, it is advisable not to take or limit alcohol.
Pregnancy
Caution
Secef 400 mg Capsule should not be used during pregnancy unless clearly necessary. Your doctor will weigh the benefits and potential risks before prescribing it. Please consult your doctor.
Breast Feeding
Unsafe
Secef 400 mg Capsule should be administered to nursing mothers only if the benefits of therapy are judged to outweigh the potential risks to the infant. Hence it is best to consult a doctor before taking the Secef 400 mg Capsule .
Driving
Caution
Caution should be exercised; Secef 400 mg Capsule usually causes drowsiness and confusion, affecting driving ability.
Liver
Caution
Secef 400 mg Capsule to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.
Kidney
Caution
Secef 400 mg Capsule to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.
Children
Caution
Secef 400 mg Capsule to be taken with caution, especially if you are children below 12. Your doctor may adjust your dose depending upon your age.
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Drug-Drug Interactions
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Co-administration of Secef 400 mg Capsule with Cholera vaccine may reduce the effectiveness of the vaccine.
How to manage the interaction:
Talk to your doctor before receiving the cholera vaccine if you are currently being treated with Secef 400 mg Capsule or have been treated within the last 14 days. To ensure adequate vaccine response, you should not receive cholera vaccine until at least 14 days after you complete your antibiotic therapy. Do not discontinue the medication without consulting a doctor.
Drug-Food Interactions
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Drug-Diseases Interactions
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Almost all antibacterial medications have been associated to reports of Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis. It can vary from mild diarrhoea to deadly colitis. Clindamycin and lincomycin are two of the most frequent offenders.
How to manage the interaction:
Antibiotics may cause Clostridioides difficile-associated diarrhoea (CDAD), which may range from mild diarrhoea to fatal colitis. Appropriate fluid and electrolyte management, protein supplementation, antibacterial treatment of C difficile, and surgical evaluation is advised.
The kidneys remove the majority of beta-lactam antibiotics as unaltered drugs and, in certain situations, as metabolites as well. In individuals with poor renal function, the blood concentrations of beta-lactam antibiotics and their metabolites may rise and their half-lives may be prolonged. According to the particular product package labelling, dosage modifications may be required. These alterations should be based on the severity of the infection as well as the degree of renal impairment. Renal function tests should be carried out on a regular basis during extended and/or high-dose therapy since these medicines have occasionally been linked to nephrotoxicity and changes in renal function.
How to manage the interaction:
The serum concentration may be increased in patients with impaired kidney function as most beta-lactam antibiotics are eliminated by the kidney. Dose adjustment may be necessary for patients with kidney dysfunction. Regular renal function tests are advised.
Hepatitis cases have been associated to the usage of several cephalosporins. Alkaline phosphatase, AST, and ALT levels have all shown a brief spike. When these medications are provided to people with hepatic problems, caution and close observation are advised.
How to manage the interaction:
Caution and monitoring is recommended in patients with liver disorders.
It has been suggested that cephalosporins can cause seizures. In particular in patients with a history of epilepsy and/or where prescribed doses of cephalosporins were exceeded because of renal impairment, cephalosporins have been associated with nonconvulsive status epilepticus (NCSE), encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia. Depending on the creatinine clearance, change the dosage. In individuals with known seizure disorders, anticonvulsant medication should be maintained. Patients should get a neurological exam to see if medication should be stopped if CNS side effects like seizures happen.
How to manage the interaction:
Cephalosporin antibiotics may trigger seizures. Dose adjustment may be needed.
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