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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTILIPEMICS

Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - SIM0003

Author Details

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FAQs

Simlo EZ 10 mg Tablet contains Ezetimibe and Simvastatin. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin works by inhibiting the production of cholesterol your body makes by itself. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart.

You are recommended to inform your doctor if you are taking niacin or niacin-containing product, as it may increase the risk of muscle problems.

Simlo EZ 10 mg Tablet may increase the risk of rhabdomyolysis (the breakdown of muscle tissue) in some patients. It is not common for everyone who takes Simlo EZ 10 mg Tablet . However, if you experience unexplained muscle pain, weakness or tenderness, especially along with fever, dark-coloured urine or unusual tiredness, please consult your doctor immediately.

You are not recommended to stop taking Simlo EZ 10 mg Tablet without consulting your doctor as it may worsen the condition and increase the risk of heart attack and stroke. Therefore, take Simlo EZ 10 mg Tablet for as long as your doctor has prescribed it, and if you experience any difficulty while taking Simlo EZ 10 mg Tablet , please consult your doctor so that the dose may be gradually reduced.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Avoid consumption of alcohol with Simlo EZ 10 mg Tablet as it may increase the risk of liver damage. Inform your doctor if you consume alcohol daily.

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Pregnancy

Unsafe

Simlo EZ 10 mg Tablet is not recommended in pregnancy as it may harm your unborn baby. If pregnancy occurs while on treatment with Simlo EZ 10 mg Tablet , it should be discontinued immediately and seek medical advice.

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Breast Feeding

Consult your doctor

It is unknown whether Simlo EZ 10 mg Tablet is excreted in the breast milk. Therefore, if you are a breastfeeding mother, inform your doctor before taking Simlo EZ 10 mg Tablet .

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Driving

Caution

Simlo EZ 10 mg Tablet usually does not affect your ability to drive or operate machinery. However, if you feel dizzy after taking Simlo EZ 10 mg Tablet , avoid driving or operating machinery.

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Liver

Caution

Simlo EZ 10 mg Tablet is contraindicated in patients with active liver disease or unexplained persistent elevations in liver transaminases. If you have liver problems, inform your doctor before taking this medicine.

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Kidney

Consult your doctor

If you have chronic kidney disease, inform your doctor before taking Simlo EZ 10 mg Tablet . Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Simlo EZ 10 mg Tablet is not recommended for children below 10 years of age as the safety and effectiveness were not established.

About Simlo EZ 10 mg Tablet

Simlo EZ 10 mg Tablet belongs to the class of medicines called 'anti hyperlipidemic drugs' or cholesterol-lowering agents primarily used to lower bad cholesterol and triglycerides (type of fat) and increase good cholesterol levels. This reduces the risk of heart attack and stroke in future. High cholesterol, known as hyperlipidemia or dyslipidemia, occurs when there is an excess of the unhealthy cholesterol balance in the blood. When the cholesterol level is high in the blood, your arteries get narrowed and clogged, contributing to heart diseases like stroke and heart attack. 

Simlo EZ 10 mg Tablet is a combination of Ezetimibe and Simvastatin. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin belongs to the class of statins or HMG-CoA reductase inhibitors that work by inhibiting the HMG-CoA reductase enzyme in the body that is essential to make cholesterol. Thereby, it decreases the production of LDL (bad cholesterol) by the liver. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart. 

Take Simlo EZ 10 mg Tablet as prescribed. Your doctor will advise how often you take Simlo EZ 10 mg Tablet based on your medical condition. Sometimes, this medicine may cause common side effects such as muscle pain, headache, diarrhoea, upper respiratory tract infection or increased liver enzyme levels. Most of these side effects of Simlo EZ 10 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are allergic to Ezetimibe, Simvastatin or other medicines, please tell your doctor. If you are aged 65 years or older, please inform your doctor. Avoid using Simlo EZ 10 mg Tablet if you are pregnant. Also, you are advised to take effective birth control measures while taking Simlo EZ 10 mg Tablet to avoid pregnancy. Please inform your doctor if you are a breastfeeding mother. Simlo EZ 10 mg Tablet is not recommended for children below 10 years of age as the safety and effectiveness were not established. If you feel dizzy after taking Simlo EZ 10 mg Tablet , avoid driving or operating machinery. 

Uses of Simlo EZ 10 mg Tablet

High cholesterol, Prevention of heart attack and stroke

Medicinal Benefits Mweb

Medicinal Benefits

Simlo EZ 10 mg Tablet contains Ezetimibe and Simvastatin, used to lower the levels of bad cholesterol and triglycerides (type of fat) and increase good cholesterol levels. This reduces the risk of heart attack and stroke in future. Ezetimibe works by reducing the cholesterol absorbed in the digestive tract. Simvastatin works by inhibiting the production of cholesterol your body makes by itself. Also, it reduces the risk of stroke or heart attack by reducing the excess cholesterol deposition in the major blood vessels of the brain and heart. Simlo EZ 10 mg Tablet is used for patients whose cholesterol levels are not controlled by diet and exercise alone. 

Directions for Use

Take Simlo EZ 10 mg Tablet with or without food as advised by your doctor. Swallow it as a whole with a glass of water. Do not break, crush or chew it.

Side Effects of Simlo EZ 10 mg Tablet

  • Muscle pain
  • Headache
  • Diarrhoea
  • Upper respiratory tract infection
  • Increased liver enzyme levels

Drug Warnings

If you are allergic to Ezetimibe, Simvastatin or any other medicines, please tell your doctor. If you are aged 65 years or older, please inform your doctor. Avoid using Simlo EZ 10 mg Tablet if you are pregnant. Also, you are advised to take effective birth control measures while taking Simlo EZ 10 mg Tablet to avoid pregnancy. Please inform your doctor if you are a breastfeeding mother. Simlo EZ 10 mg Tablet is not recommended for children below 10 years of age as the safety and effectiveness were not established. If you feel dizzy after taking Simlo EZ 10 mg Tablet , avoid driving or operating machinery. Maintain a low-fat diet along with Simlo EZ 10 mg Tablet for effective results. If you have diabetes or are at risk of developing diabetes, your doctor will monitor you closely while on treatment with Simlo EZ 10 mg Tablet . You are likely to be at risk of developing diabetes if you have high levels of sugars and fats in the blood, high blood pressure and are overweight.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Darunavir and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Darunavir and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Mifepristone with Simlo EZ 10 mg Tablet can increase the blood levels of Simlo EZ 10 mg Tablet, which may increase the risk of side effects.

How to manage the interaction:
Taking Simlo EZ 10 mg Tablet with Mifepristone is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Simlo EZ 10 mg Tablet:
Taking Ritonavir and Simlo EZ 10 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Simlo EZ 10 mg Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, tiredness, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, contact a doctor. Do not discontinue any medications without consulting a doctor.
SimvastatinFosamprenavir
Critical
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Fosamprenavir and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Fosamprenavir and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Indinavir and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Indinavir and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinTipranavir
Critical
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Tipranavir and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Tipranavir and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Simlo EZ 10 mg Tablet:
Coadministration of erythromycin and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Erythromycin and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain or weakness, dark-colored urine, joint pain, itching, fatigue, or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinNelfinavir
Critical
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Nelfinavir and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nelfinavir and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinNefazodone
Critical
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Nefazodone and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nefazodone and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Simlo EZ 10 mg Tablet:
Combining Atazanavir and Simlo EZ 10 mg Tablet can increase the blood levels and effects of Simlo EZ 10 mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Atazanavir and Simlo EZ 10 mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • POSACONAZOLE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • TELITHROMYCIN
  • INDINAVIR
  • SAQUINAVIR
  • NELFINAVIR
  • TIPRANAVIR
  • RITONAVIR
  • ATAZANAVIR
  • NEFAZODONE
  • COBICISTAT
  • DANAZOL
  • CYCLOSPORINE
  • TELAPREVIR
  • BOCEPREVIR
  • FENOFIBRATE
  • LOMITAPIDE
  • GEMFIBROZIL
  • AMIODARONE
  • DRONEDARONE
  • DILTIAZEM
  • VERAPAMIL
  • RANOLAZINE
  • AMLODIPINE
  • COLCHICINE
  • NIACIN
  • WARFARIN

Habit Forming

No

Special Advise

  • Regular blood tests are recommended to monitor liver function while on treatment with Simlo EZ 10 mg Tablet .

Diet & Lifestyle Advise

  • Maintain a low-fat diet. Limit your intake of dairy products made with whole milk and red meat. Prefer skim milk and fat-free or low-fat dairy products.
  • Eat a healthy diet that includes fruits, vegetables, fish, poultry, whole grains, nuts and cut-down beverages, and processed and sugary foods.
  • Do regular exercises such as swimming, cycling, walking, or dancing and focus on losing weight, as obesity also raises bad cholesterol and lowers good cholesterol.
  • Avoid smoking and alcohol consumption.

Simlo EZ 10 mg Tablet Substitute

Always consult your doctor before taking any new medications and supplements

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