Sitara-M 50/500mg Tablet is a combination drug of Sitagliptin (DPP4 inhibitors) and Metformin (Biguanides) belongs to the class of anti-diabetic. Type 2 diabetes is a condition in which either the body stops producing enough insulin (the hormone which helps to decrease sugar levels in the blood) or there is resistance to the action of insulin. As a result, insulin is produced in large amounts but it is not able to act on the organs of the body.

Sitagliptin belongs to the class of dipeptidyl peptidase-4 (DPP-4) inhibitors which works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Another medicine Metformin belongs to the class of biguanides which lowers glucose production in the liver, delays glucose absorption from intestines and increases the body's sensitivity to insulin. Together, it prevents blood glucose levels from rising to very high levels after meals.

Sitara-M 50/500mg Tablet should be taken with food to avoid an upset stomach. Sitara-M 50/500mg Tablet should be taken at the same time of the day each time for best results. For better advice, your doctor will decide, what dose should be taken and it can change timely depending upon your condition. The most common side effect of Sitara-M 50/500mg Tablet is hypoglycemia (low blood glucose levels) characterised by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, upper respiratory symptoms.

Sitara-M 50/500mg Tablet should not be stopped even if you feel better, without consulting your doctor as sugar level keeps changing. If you stop taking Sitara-M 50/500mg Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Sitara-M 50/500mg Tablet should not be taken if you have type 1 diabetes mellitus, severe kidney or liver disease. Please inform your doctor if you have any type of heart disease, is or planning to get pregnant or breastfeeding.

 Sitara-M 50/500mg Tablet helps your pancreas to produce more insulin, make effective utilization of insulin, and decreases excess of sugar that your liver makes. It helps in controlling rise of blood sugar level in your body after meal. Besides this, it does not cause weight gain in the prolonged use. Sitara-M 50/500mg Tablet plays a vital role in controlling blood sugar levels and prevents serious complications of diabetes like eyesight loss (retinopathy), kidney (nephropathy), nerve damage (neuropathy), diabetic foot ulcer and delayed wound healing.

Swallow it as a whole with water; do not crush, break or chew it.

Sitara-M 50/500mg Tablet should not be used in patients with type 1 diabetes or with diabetic ketoacidosis. Some diabetic patients, while taking Sitara-M 50/500mg Tablet , might develop a rare but serious condition called lactic acidosis. In this condition, too much lactic acid is accumulated in the blood, which can damage the working of your liver and kidney required to eliminate excess lactic acid from the blood. Before you start taking Sitara-M 50/500mg Tablet , tell your doctor if you’ve ever had pancreatitis (inflammation of the pancreas), kidney disease, and low vitamin B12 levels. Sitara-M 50/500mg Tablet , when used with insulin, Sitara-M 50/500mg Tablet may lower the blood sugar level, leading to hypoglycaemia, which can be fatal. In this case, your doctor may adjust the dose by lowering the insulin dose or Sitara-M 50/500mg Tablet . Prolonged intake of Sitara-M 50/500mg Tablet may lower your thyroid-stimulating hormone (TSH); hence, an annual check-up of TSH is recommended. In rare cases, you may also develop a serious skin reaction known as bullous pemphigoid that requires immediate medical attention. Tell your doctor if you are going to have a diagnostic test with an injection of dye or X-ray contrast agent. You should stop using Sitara-M 50/500mg Tablet for a short time before an X-ray procedure.