apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
Insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. Spexib 150 mg Capsule 10's

Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Spexib 150 mg Capsule 10's, Pack of 10 CAPSULES
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
Know More
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

tooltip

Composition :

CERITINIB-150MG

Manufacturer/Marketer :

Novartis India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

KINASE INHIBITORS

Country of origin

India

Manufacturer/Marketer address

Sandoz House, Shiv Sagar Estate, Worli Mumbai -400 018, India
Other Info - SPE0179

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:50 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

While taking Spexib Capsule, visit your doctor at all the appointments to ensure treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Spexib Capsule.

Elevations of lipase and/or amylase and pancreatitis can occur during treatment. Your doctor monitors lipase and amylase prior to treatment and periodically thereafter, as clinically indicated. If clinically insignificant values are observed, your doctor either withholds them or reduces the Spexib Capsule.

In some cases, Spexib Capsule can cause bradycardia. Monitoring heart rate and blood pressure regularly is recommended. If this condition persists, Withhold the dose or permanently discontinue Spexib Capsule and consult the doctor immediately.

Spexib Capsule can cause hyperglycemia. Your doctor monitors fasting glucose prior to treatment and periodically thereafter. Your doctor may prescribe anti-hyperglycemic medications, reduce the dose, or permanently discontinue Spexib Capsule if required.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
bannner image

Alcohol

Caution

Avoid alcohol consumption while on treatment with Spexib Capsule.

bannner image

Pregnancy

Unsafe

Spexib Capsule should not be used during pregnancy as it may cause embryo-fetal toxicity. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

bannner image

Breast Feeding

Unsafe

You should not breastfeed during the treatment with Spexib Capsule and for two weeks after your last dose of this medication.

bannner image

Driving

Caution

Spexib Capsule may cause tiredness and weakness (fatigue), impacting the ability to drive or use machines.

bannner image

Liver

Caution

Spexib Capsule might harm the liver. During the treatment, your doctor may perform blood tests at least once a month to monitor your liver. Notify your physician straight away if you experience any of the following symptoms: Fatigue, skin itchiness, yellowing of the skin or the whites of your eyes, nausea, vomiting, decreased appetite, right-side stomach pain, dark or brown (tea-coloured) urine, and an increased propensity to bleed or bruise.

bannner image

Kidney

Consult your doctor

It is not known how Spexib Capsule affects when used in kidney-impaired patients. Please consult your doctor if you have kidney problems or a disease history.

bannner image

Children

Unsafe

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

Reference

  1. https://www.novartis.com/us-en/sites/novartis_us/files/zykadia.pdf
  2. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/ceritinib
  3. https://medlineplus.gov/druginfo/meds/a614027.html
  4. https://reference.medscape.com/drug/zykadia-ceritinib-999936
  5. https://chemocare.com/druginfo/ceritinib
  6. https://www.macmillan.org.uk/cancer-information-and-support/lung-cancer/non-small-cell-lung-cancer
  7. https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=7397
  8. https://www.drugs.com/drug-interactions/ceritinib.html

About Spexib Capsule

Spexib Capsule belongs to a class of protein kinase inhibitors primarily used to manage or treat a type of lung cancer called non-small cell lung cancer that is ALK-positive, and you have already had treatment with a drug. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

Spexib Capsule contains Ceritinib, which works by blocking a protein that causes cancer cells to grow and multiply. This helps to slow or stop the spread of cancer cells.

Take Spexib Capsule as prescribed. Follow your doctor's instructions to get the maximum benefit. Sometimes, you may experience certain common side effects, such as diarrhoea, feeling or being sick, abdominal pain, vomiting, fatigue (feeling overtired), decreased appetite, and weight loss. You are advised to talk to your doctor if you persistently experience any of these side effects.

Before taking the Spexib Capsule, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Spexib Capsule can cause fetal harm when in pregnancy. Contact your doctor immediately if you or your partner becomes pregnant while you are on treatment. Breastfeeding is not recommended during the treatment. Do not consume alcohol during treatment with this medicine. The safety and effectiveness of Spexib Capsule in children have not been established.

Uses of Spexib Capsule

Non-small cell lung cancer (NSCLC)

Medicinal Benefits Mweb

Medicinal Benefits

Spexib Capsule contains Ceritinib, which belongs to a class of protein kinase inhibitors primarily used to manage or treat Non-small cell lung cancer (NSCLC) that is ALK-positive, and you have already had treatment with a drug. Ceritinib blocks proteins in cancer cells that encourage the cancer to grow. In some cases, if you have advanced NSCLC and have not received any other treatments, you may be prescribed Ceritinib.  If you haven't had any prior therapies, you may have Ceritinib.

Directions for Use

Spexib Capsule should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. Your doctor determines the dose and duration based on your health condition.

Side Effects of Spexib Capsule

  • Diarrhea
  • Feeling or being sick
  • Abdominal pain
  • Vomiting
  • Fatigue (feeling overtired)
  • Decreased appetite
  • Weight loss
  • Diarrhea
  • Constipation
  • Loss of appetite
  • Abdominal pain
  • Indigestion
  • Skin changes
  • Anaemia (few or abnormal red blood cells)

Drug Warnings

Before taking the Spexib Capsule, let your doctor know about all your medical conditions (especially liver disease, heart problems, QT interval prolongation, hyperglycemia, bradycardia, stomach problems and/or pancreatitis), sensitivities or allergic conditions, and all medications you are using. Exposure of an unborn child to this medication could cause birth defects, so you should not become pregnant or father a child while on this medication. Effective birth control is required throughout treatment and at least six months after treatment for women and at least three months after treatment for males. You should not breastfeed while taking this medication for two weeks after your last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements. 

Drug-Drug Interactions

verifiedApollotooltip
CeritinibIvabradine
Critical
CeritinibAlfuzosin
Critical

Drug-Drug Interactions

Login/Sign Up

CeritinibIvabradine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Coadministration of ivabradine with Spexib 150 mg Capsule can increase the levels and effects of ivabradine.

How to manage the interaction:
Taking Ivabradine with Spexib 150 mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CeritinibAlfuzosin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Coadministration of alfuzosin and Spexib 150 mg Capsule can increase the risk of developing side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Alfuzosin is not recommended as it can result in an interaction; it should be taken only if your doctor has advised it. However, if you experience dizziness, headache, palpitations, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
CeritinibSilodosin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Co-administration of Spexib 150 mg Capsule and Silodosin together can increase the effect of Silodosin and increase the risk for side effects.

How to manage the interaction:
Taking Silodosin and Spexib 150 mg Capsule together is not recommended as it can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, headache, flushing, nasal congestion, or heart palpitation. Do not discontinue any medications without consulting a doctor.
CeritinibSimvastatin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Combining Spexib 150 mg Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Spexib 150 mg Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
CeritinibMidazolam
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule and midazolam may significantly increase the blood levels and effects of midazolam.

How to manage the interaction:
Although taking Spexib 150 mg Capsule and midazolam together may result in an interaction, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
CeritinibRanolazine
Critical
How does the drug interact with Spexib 150 mg Capsule:
When Spexib 150 mg Capsule is taken with Ranolazine, may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Taking Ranolazine with Spexib 150 mg Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any side effects like lightheadedness, fainting, dizziness, or fast or pounding heartbeats, consult a doctor. Do not discontinue any medications without consulting a doctor.
CeritinibHalofantrine
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with Halofantrine can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Halofantrine is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
CeritinibDronedarone
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking dronedarone with Spexib 150 mg Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Dronedarone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CeritinibZiprasidone
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Spexib 150 mg Capsule with Ziprasidone is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CeritinibPhenytoin
Critical
How does the drug interact with Spexib 150 mg Capsule:
Taking Spexib 150 mg Capsule with phenytoin may significantly reduce the blood levels and effectiveness of Spexib 150 mg Capsule.

How to manage the interaction:
Taking Phenytoin with Spexib 150 mg Capsule is not recommended as it can cause an interaction, it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

Login/Sign Up

Drug-Drug Interactions Checker List

  • DILTIAZEM
  • METOPROLOL
  • LITHIUM
  • AZITHROMYCIN
  • ERYTHROMYCIN
  • ESCITALOPRAM
  • AMPRENAVIR
  • ATAZANAVIR
  • EFAVIRENZ
  • FINGOLIMOD
  • HALOTHANE
  • QUINIDINE
  • KETOCONAZOLE
  • RIFAMPICIN
  • MIDAZOLAM
  • WARFARIN

Habit Forming

No

Special Advise

  • Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests to check your body's response to Spexib Capsule.
  • Pregnancy testing is recommended before starting treatment with Spexib Capsule.
  • Do not donate sperm while on medication or within three months following completion of therapy.

Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Have a query?

Buy best Neoplastic Disorders products by

Buy Now
Add to Cart