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  1. Home
  2. Medicine

  3. Synapze-M Tablet 10's

Prescription drug
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Synapze-M Tablet 10's, Pack of 10 TabletS
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Extra 15% Off with Bank Offers

Composition :

EPALRESTAT-50MG + METHYLCOBALAMIN-500MCG

Manufacturer/Marketer :

Ethix Health Care

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIDIABETICS

Country of origin

India

Manufacturer/Marketer address

Deonghat, Solan, Himachal Pradesh – 173 211.
Other Info - SYN0289

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sureshvarma D

Reviewed By

Sureshvarma D

MPharma

Last Updated

Jul 8, 2025 | 9:39 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Synapze-M Tablet is a combination of two drugs, namely: Epalrestat and Methylcobalamin. Epalrestat prevents the accumulation of sorbitol by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Synapze-M Tablet helps in treating diabetic neuropathy.

Diarrhoea could be a side-effect of Synapze-M Tablet . Drink plenty of fluids to prevent dehydration and consume non-spicy meals if you experience diarrhoea. Consult your doctor if you have severe diarrhoea.

Inform your doctor if you notice any cut/sore on your feet that is not healing or if you have a tingling/burning sensation in your feet/arms causing a hamper to the daily routine. If you experience trouble in sexual function, digestion, or urination, please consult a doctor. Examine your feet daily for lesions and wear proper footwear to prevent diabetic neuropathy.

Do not discontinue Synapze-M Tablet without consulting your doctor. To treat your condition effectually, continue taking Synapze-M Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Synapze-M Tablet .

Synapze-M Tablet may cause peripheral oedema. Peripheral oedema is the swelling of the hands and lower legs. Avoid sitting or standing for too long. Raise your legs by putting a pillow under the legs while lying down.

Synapze-M Tablet does not help in controlling diabetes. Synapze-M Tablet is indicated to treat neuropathic pain. It is recommended to adhere to your diabetic medicines to keep your blood sugar levels at normal.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Avoid consumption of alcohol while taking Synapze-M Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Synapze-M Tablet ; your doctor will decide whether Synapze-M Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Synapze-M Tablet may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Limited information is available regarding the use of Synapze-M Tablet in patients with liver disease. Please consult your doctor.

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Kidney

Caution

Limited information is available regarding the use of Synapze-M Tablet in patients with kidney impairment. Please consult your doctor.

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Children

Caution

Synapze-M Tablet should not be given to children as safety and efficacy have not been established.

Product Substitutes

Reference

  1. https://www.mims.com/malaysia/drug/info/epalrestat?mtype=generic
  2. https://www.medindia.net/doctors/drug_information/epalrestat.htm
  3. https://www.drugs.com/mtm/methylcobalamin-vitamin-b12.html

About Synapze-M Tablet

Synapze-M Tablet is a combination medicine indicated for the management of diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It primarily damages the nerves in the legs and feet. Diabetic neuropathic pain is common in patients with type 1 and type 2 diabetes.
 
Synapze-M Tablet contains Epalrestat and Methylcobalamin. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol, thereby preventing the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Synapze-M Tablet helps in treating diabetic neuropathy.
 
You are advised to take Synapze-M Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as nausea, vomiting, diarrhoea, dizziness, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Synapze-M Tablet may cause drowsiness and dizziness, so drive only if you are alert. Synapze-M Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Synapze-M Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Uses of Synapze-M Tablet

Diabetic neuropathy (diabetic nerve pain)

Medicinal Benefits Mweb

Medicinal Benefits

Synapze-M Tablet is a combination of two drugs, namely: Epalrestat and Methylcobalamin. Synapze-M Tablet is indicated for the management of diabetic neuropathy. Epalrestat works by inhibiting the aldose reductase enzyme, which catalyses the conversion of glucose to sorbitol. This prevents the accumulation of sorbitol. Accumulation of sorbitol occurs due to hyperglycaemia in patients suffering from diabetes which leads to nerve pain. Methylcobalamin helps in the rejuvenation and protection of damaged nerve cells by producing a substance called myelin. Together, Synapze-M Tablet helps in treating diabetic neuropathy.

Directions for Use

Swallow Synapze-M Tablet as a whole with a glass of water; do not chew or break it.

Side Effects of Synapze-M Tablet

  • Dizziness
  • Nausea
  • Vomiting
  • Headache
  • Diarrhoea

Drug Warnings

Do not take Synapze-M Tablet if you are allergic to any of its components. Inform your doctor if you have liver or kidney problems. Consult your doctor if you are pregnant or breastfeeding. Synapze-M Tablet may cause drowsiness and dizziness, so drive only if you are alert. Synapze-M Tablet is not recommended for children as safety and effectiveness have not been established. Avoid consuming alcohol with Synapze-M Tablet as it could lead to increased drowsiness and sleepiness. 

Drug-Drug Interactions Checker List

  • CHLORAMPHENICOL
  • METFORMIN

Habit Forming

No

Diet & Lifestyle Advise

  • Include food rich in vitamin B and D in your diet.
  • Include cayenne pepper in your diet as it can help in lowering neuropathic pain.
  • Exercising regularly helps in improving overall health and combating pain. 
  • Rest well, get plenty of sleep.
  • Try taking a warm bath as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity and improves coping skills.
  • Acupuncture can be helpful by stimulating pressure points.
  • Using essential oils for massages can help increase circulation.

Synapze-M Tablet Substitute

Substitutes safety advice

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