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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
48 Hrs returnable
COD available

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Composition :

TOFACITINIB-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra.
Other Info - TFC0002

Author Details

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FAQs

TFCT NIB Tablet works by blocking Janus kinase enzyme, thereby lowers inflammation and symptoms associated with rheumatoid and psoriatic arthritis.

Hypertension/high blood pressure could be a side-effect of TFCT NIB Tablet . Consult your doctor before taking TFCT NIB Tablet if you have high blood pressure or if you are taking anti-hypertensive medicines.

Diarrhoea might be a side-effect of TFCT NIB Tablet . Eat non-spicy meals and drink plenty of fluids to prevent dehydration if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

TFCT NIB Tablet might impair fertility in females of reproductive potential. It is not known if the effect is reversible. Therefore, talk to a doctor before starting TFCT NIB Tablet if you are trying to become pregnant or if you have any concerns regarding this.

TFCT NIB Tablet affects the immune system and might lower the ability of the immune system to fight infections. Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

It is not known if alcohol interacts with TFCT NIB Tablet , so please consult a doctor.

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Pregnancy

Unsafe

TFCT NIB Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with TFCT NIB Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking TFCT NIB Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe if prescribed

TFCT NIB Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. TFCT NIB Tablet is not recommended for patients with severe liver problems.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

TFCT NIB Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

About TFCT NIB Tablet

TFCT NIB Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
TFCT NIB Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking TFCT NIB Tablet if you are pregnant or breastfeeding. TFCT NIB Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of TFCT NIB Tablet

Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Medicinal Benefits Mweb

Medicinal Benefits

TFCT NIB Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. TFCT NIB Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. TFCT NIB Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

Directions for Use

Swallow TFCT NIB Tablet as a whole with a glass of water; do not chew or break it.

Side Effects of TFCT NIB Tablet

  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Upper respiratory tract infection
  • Cold
  • High blood pressure

Drug Warnings

Do not take TFCT NIB Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking TFCT NIB Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking TFCT NIB Tablet . TFCT NIB Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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TofacitinibPaclitaxel
Severe
TofacitinibDaunorubicin
Severe

Drug-Drug Interactions

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TofacitinibPaclitaxel
Severe
How does the drug interact with TFCT NIB Tablet:
Taking TFCT NIB Tablet with Paclitaxel may increase the risk of infection.

How to manage the interaction:
Although taking Paclitaxel and TFCT NIB Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibDaunorubicin
Severe
How does the drug interact with TFCT NIB Tablet:
When TFCT NIB Tablet is taken with Daunorubicin, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between TFCT NIB Tablet and Daunorubicin, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibVincristine
Severe
How does the drug interact with TFCT NIB Tablet:
Taking TFCT NIB Tablet with Vincristine may increase the risk of infection.

How to manage the interaction:
Co-administration of Vincristine with TFCT NIB Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
TofacitinibChlorambucil
Severe
How does the drug interact with TFCT NIB Tablet:
Taking TFCT NIB Tablet with Chlorambucil may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between TFCT NIB Tablet and Chlorambucil, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blo, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibItraconazole
Severe
How does the drug interact with TFCT NIB Tablet:
Taking Itraconazole with TFCT NIB Tablet may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between TFCT NIB Tablet and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
TofacitinibSirolimus
Severe
How does the drug interact with TFCT NIB Tablet:
Coadministration of TFCT NIB Tablet with Sirolimus may increase the risk or severity of developing infection.

How to manage the interaction:
Although there is a possible interaction between Sirolimus and TFCT NIB Tablet, you can take these medicines together if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TofacitinibGemcitabine
Severe
How does the drug interact with TFCT NIB Tablet:
Coadministration of TFCT NIB Tablet and Gemcitabine can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between TFCT NIB Tablet and Gemcitabine, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
TofacitinibCiclosporin
Severe
How does the drug interact with TFCT NIB Tablet:
Co-administration of TFCT NIB Tablet with cyclosporine may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, TFCT NIB Tablet can be taken with ciclosporin if prescribed by the doctor. Consult the prescriber if you experience side effects such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without a doctor's advice.
TofacitinibRituximab
Severe
How does the drug interact with TFCT NIB Tablet:
Taking Rituximab and TFCT NIB Tablet may increase the risk infections.

How to manage the interaction:
Taking TFCT NIB Tablet with Rituximab together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
TofacitinibFosamprenavir
Severe
How does the drug interact with TFCT NIB Tablet:
Co-administration of TFCT NIB Tablet with fosamprenavir may increase the blood levels of TFCT NIB Tablet which increases risk of side effects.

How to manage the interaction:
Although taking TFCT NIB Tablet and Fosamprenavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking TFCT NIB Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with TFCT NIB Tablet, as it can lead to an interaction.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • FLUCONAZOLE
  • KETOCONAZOLE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • CYCLOSPORINE
  • TACROLIMUS
  • PREDNISONE

Habit Forming

No

Special Advise

  • Your doctor may advise you to get a blood test done before starting treatment with TFCT NIB Tablet , after 4-8weeks of treatment and then every three months to determine your blood cell count.
  • Your doctor might advise regular tests to determine blood cholesterol levels and liver functioning.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties.
  • If you are a woman of child-bearing potential, use effective contraception during the treatment with TFCT NIB Tablet and for 4 weeks after discontinuation.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

TFCT NIB Tablet Substitute

Substitutes safety advice
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