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  3. Tofadoz-11 XR Tablet 10's

Prescription drug
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS

Composition :

TOFACITINIB-11MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

[ANTIRHEUMATICS, DISEASE MODIFYING ANTIRHEUMATIC DRUGS (DMARDs)]

Country of origin

India

Manufacturer/Marketer address

Msn Laboratories Pvt.Ltd., Msn House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India
Other Info - TOF0061

Author Details

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Disclaimer

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Alcohol

Safe if prescribed

It is not known if alcohol interacts with Tofadoz 11 XR Tablet , so please consult a doctor.

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Pregnancy

Consult your doctor

Tofadoz 11 XR Tablet must not be taken during pregnancy. If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofadoz 11 XR Tablet and for 4 weeks after discontinuation.

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Breast Feeding

Consult your doctor

Avoid breastfeeding while taking Tofadoz 11 XR Tablet . Please consult a doctor if you have any concerns.

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Driving

Safe if prescribed

Tofadoz 11 XR Tablet generally does not affect your ability to drive. However, drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this. Tofadoz 11 XR Tablet is not recommended for patients with severe liver problems.

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Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Tofadoz 11 XR Tablet is not recommended for children below 18 years as safety and effectiveness were not established.

About Tofadoz 11 XR Tablet

Tofadoz 11 XR Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is an inflammatory condition of the joints, often associated with psoriasis. Ulcerative colitis is an inflammatory disease of the large intestine.
 
Tofadoz 11 XR Tablet contains 'Tofacitinib' which works by blocking the Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. 
 
In some cases, you may experience common side-effects such as diarrhoea, headache, upper respiratory tract infection, cold, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Inform your doctor if you have an active infection, if you have a condition that increases the chance of having infections, if you are taking immunosuppressants, medicines that affect the immune system or corticosteroids. Avoid taking Tofadoz 11 XR Tablet if you are pregnant or breastfeeding. Tofadoz 11 XR Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Tofadoz 11 XR Tablet

Rheumatoid arthritis, Psoriatic arthritis, Ulcerative colitis.

Medicinal Benefits Mweb

Key Benefits

Tofadoz 11 XR Tablet belongs to a group of medicines called Janus kinase inhibitors used to treat rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis. Tofadoz 11 XR Tablet works by blocking Janus kinase enzyme, thereby lowering inflammation and symptoms associated with rheumatoid and psoriatic arthritis. Tofadoz 11 XR Tablet is indicated for patients with moderate to severe rheumatic arthritis, and psoriatic arthritis who have had intolerance or inadequate response to methotrexate or DMARDs (Disease-Modifying Anti-Rheumatic Drugs).

Directions for Use

Swallow Tofadoz 11 XR Tablet as a whole with a glass of water; do not chew or break it.

Side Effects of Tofadoz 11 XR Tablet

  • Headache
  • Diarrhoea
  • Vomiting
  • Nausea
  • Upper respiratory tract infection
  • Cold
  • High blood pressure

Drug Warnings

Do not take Tofadoz 11 XR Tablet if you are allergic to any of its components; if you have a severe infection, bloodstream infection, active tuberculosis, or if you have severe liver problems such as cirrhosis. Avoid taking Tofadoz 11 XR Tablet if you are pregnant or breastfeeding. Inform your doctor if you have an infection, symptoms of infection, a condition that increases chances of infection, are taking any medicines that affect the immune system; have or had a history of tuberculosis, or were in close contact with someone who has/had tuberculosis; chronic lung disease, liver problems, hepatitis B/C, cancer, are at a high risk of developing skin cancer, inflammation/ulcers of the large intestine, kidney problems, planning to get vaccinated, heart problems, high cholesterol, high blood pressure, heart attack, diabetes, or blood clotting problems. If your white blood cell count or red blood cell count is low, avoid taking Tofadoz 11 XR Tablet . Tofadoz 11 XR Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Tofadoz-11 XR Tablet:
Taking Clarithromycin may boost the blood levels of Tofadoz-11 XR Tablet, increasing side effects such as low blood cell count, anemia, serious infections, and elevated blood lipid levels.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Tofadoz-11 XR Tablet if prescribed by the doctor. Consult the prescriber if you experience paleness, fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet and Mercaptopurine increases the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Mercaptopurine and Tofadoz-11 XR Tablet, you can take these medicines together if prescribed by your doctor. If you experience any of these symptoms - serious infections, complications, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain or burning when you pee - contact your doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet together with lenalidomide may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between lenalidomide and Tofadoz-11 XR Tablet, it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofadoz-11 XR Tablet:
Co-administration of Tofadoz-11 XR Tablet with cyclosporine may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Tofadoz-11 XR Tablet can be taken with ciclosporin if prescribed by the doctor. Consult the prescriber if you experience side effects such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without a doctor's advice.
How does the drug interact with Tofadoz-11 XR Tablet:
When Tofadoz-11 XR Tablet is taken with Vinblastine it may increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Vinblastine and Tofadoz-11 XR Tablet, but it can be taken if prescribed by a doctor. It is important to keep a close eye on your symptoms. If you notice any of the following - fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating - make sure to contact your doctor right away. They will be able to help you and provide the necessary care. Do not discontinue any medications without first consulting your doctor.
TofacitinibBoceprevir
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with Boceprevir may increases the blood levels of Tofadoz-11 XR Tablet which increases risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tofadoz-11 XR Tablet and Boceprevir, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, fainting, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting your doctor.
TofacitinibTelithromycin
Severe
How does the drug interact with Tofadoz-11 XR Tablet:
When Tofadoz-11 XR Tablet is taken with Telithromycin, it can slow down the way the body breaks down Tofadoz-11 XR Tablet.

How to manage the interaction:
Taking Tofadoz-11 XR Tablet with Telithromycin together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with leflunomide can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between leflunomide and Tofadoz-11 XR Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tofadoz-11 XR Tablet:
When Tofadoz-11 XR Tablet is taken with Daunorubicin, it may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofadoz-11 XR Tablet and Daunorubicin, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Tofadoz-11 XR Tablet:
Taking Tofadoz-11 XR Tablet with Topotecan may increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Tofadoz-11 XR Tablet and Topotecan, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOFACITINIB-11MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consuming grapefruit products while taking Tofadoz-11 XR Tablet can increase the risk of side effects. Avoid consuming grapefruit products while being treated with Tofadoz-11 XR Tablet, as it can lead to an interaction.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • FLUCONAZOLE
  • KETOCONAZOLE
  • AZATHIOPRINE
  • MERCAPTOPURINE
  • CYCLOSPORINE
  • TACROLIMUS
  • PREDNISONE

Habit Forming

No

Special Advise

  • Your doctor may advise you to get a blood test done before starting treatment with Tofadoz 11 XR Tablet , after 4-8weeks of treatment and then every three months to determine your blood cell count.
  • Your doctor might advise regular tests to determine blood cholesterol levels and liver functioning.
  • Inform your doctor if you notice painful blisters on the skin or if you experience breathing difficulties.
  • If you are a woman of child-bearing potential, use effective contraception during the treatment with Tofadoz 11 XR Tablet and for 4 weeks after discontinuation.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

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