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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

NATALIZUMAB-20MG/ML

Manufacturer/Marketer :

Biogen Idec Biotech India Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

MONOCLONAL ANTIBODIES

Country of origin

India

Manufacturer/Marketer address

A-1/292, Ground Floor Janak Puri New Delhi West Delhi Dl 110058 In
Other Info - TYS0005

FAQs

Tysabri 300 mg Injection works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This alters the gene expression of blood monocytes and thus helps reduce inflammation.

Inform your doctor about your complete medical and medication history especially, if you have any history of serious infections, tuberculosis, liver or kidney diseases, or a weak immune system, as it can worsen your health condition.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Consult your doctor

It is unknown whether alcohol interacts with Tysabri 300 mg Injection. Consult your doctor for any concerns regarding this.

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Pregnancy

Caution

If you are pregnant or planning pregnancy, inform your doctor before receiving Tysabri 300 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Tysabri 300 mg Injection is known to pass in the breastmilk. Hence, if you are breastfeeding, inform your doctor before receiving Tysabri 300 mg Injection. Your doctor may administer this medicine only if the benefits outweigh the risks.

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Driving

Not applicable

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Liver

Caution

Tysabri 300 mg Injection is known to cause hepatotoxicity in some patients. Hence, caution should be exercised. Inform your doctor if you observe any symptoms of tiredness, loss of appetite, dark urine, yellowing of the skin and eyes, or pain in the abdomen. Dose adjustment may be needed in patients with liver impairment.

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Kidney

Caution

Tysabri 300 mg Injection should be used with caution if you have kidney disease. Dose adjustment may be needed in patients with liver impairment.

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Children

Unsafe

Tysabri 300 mg Injection is not recommended in children below 18 years of age as the safety and efficacy are not established.

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Keep Refrigerated. Do not freeze.Prepaid payment required.

About Tysabri 300 mg Injection

Tysabri 300 mg Injection belongs to the class of monoclonal antibodies. It is used in the treatment of multiple sclerosis (a condition in which the immune system attacks the protective covering of the nerves called myelin, causing disrupted communication between the brain and body) and moderately to severe Crohn’s disease (a chronic bowel disease that affects any part of the gastrointestinal tract, mainly small and large intestine) in patients who are unable to tolerate conventional Crohn’s disease therapy and inhibitors of TNF-α.

Tysabri 300 mg Injection consists of Natalizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation.

Tysabri 300 mg Injection may cause certain side effects, such as nausea, headache, fever, joint pain, upper respiratory tract infections, abdominal discomfort, diarrhoea, tiredness, back pain, itching, depression, and injection site reactions. Most of these side effects do not require medical attention. However, if these side effects persist, please consult your doctor. Tysabri 300 mg Injection will be administered by a trained healthcare doctor. Hence, do not self-administer. 

Tysabri 300 mg Injection should be avoided if you are allergic to any of its components.  Inform your doctor if you have any history of serious infections, tuberculosis, liver or kidney diseases, or a weak immune system, as it can worsen your health condition. Tysabri 300 mg Injection is contraindicated in patients with Progressive Multifocal Leukoencephalopathy (PML), as it can cause serious adverse effects. Consult the doctor if you are pregnant or breastfeeding.

Uses of Tysabri 300 mg Injection

Multiple sclerosis, Crohn’s disease.

Medicinal Benefits Mweb

Medicinal Benefits

Tysabri 300 mg Injection consists of Natalizumab, which belongs to the class of integrin receptor antagonists. It works by binding to the chemical substance called α4β7 integrin (present on the surface of the WBC that enters the gut), which is responsible for inflammation. This causes inhibition and alters the gene expression of blood monocytes and thus helps reduce inflammation of the bowel disease. It is used in the treatment of moderately to severe Crohn’s disease and multiple sclerosis.

Directions for Use

Tysabri 300 mg Injection will be administered by a healthcare professional. Do not self-administer.

Side Effects of Tysabri 300 mg Injection

  • Injection site reactions
  • Headache
  • Nausea
  • Upper respiratory tract infections.
  • Joint pain
  • Tiredness
  • Cough
  • Back pain
  • Itching
  • Diarrhoea
  • Depression

Drug Warnings

Inform your doctor if you have any history of serious infections, tuberculosis, liver, or kidney diseases, or a weak immune system, as it can worsen your health condition. This medicine is contraindicated in patients with leukemia or lymphoma, or an organ transplant as it can cause life-threatening conditions. Tysabri 300 mg Injection may cause serious reactions including infusion-related or allergic reactions. This medicine may also increase the risk of serious infections and hypersensitivity reactions in some patients. Hence, patients should be carefully monitored for any changes during and after the treatment course. Tysabri 300 mg Injection is not recommended for use in children below 18 years of age as safety and efficacy are not established. This medicine can cause Progressive Multifocal Leukoencephalopathy (PML) in most patients with compromised immune system. The chance of getting PML is more if the patient is exposed to John Cunningham Virus, if received Tysabri 300 mg Injection for longer than 2 years or treated with other medicine that weakens your immune system. Hence it is important to inform your doctor about your complete medication history and previous medical history before receiving Tysabri 300 mg Injection.

Drug-Drug Interactions

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NatalizumabPomalidomide
Severe
NatalizumabAsparaginase
Severe

Drug-Drug Interactions

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NatalizumabPomalidomide
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking Pomalidomide with Tysabri 300 mg Injection 15 ml can increase the likelihood and seriousness of infections.

How to manage the interaction:
Taking Pomalidomide with Tysabri 300 mg Injection 15 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not discontinue any medications without a doctor's advice.
NatalizumabAsparaginase
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking Asparaginase with Tysabri 300 mg Injection 15 ml together can increase the risk of developing serious infections.

How to manage the interaction:
Taking Asparaginase with Tysabri 300 mg Injection 15 ml together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without talking to a doctor.
NatalizumabDimethyl fumarate
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Co-administration of Dimethyl fumarate with Tysabri 300 mg Injection 15 ml can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Dimethyl fumarate with Tysabri 300 mg Injection 15 ml can possibly result in an interaction, but it can be taken if a doctor has advised it. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, burning during urination, weakness, vision problems, or confusion. If you experience any of these symptoms, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NatalizumabIdarubicin
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking Idarubicin and Tysabri 300 mg Injection 15 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Idarubicin and Tysabri 300 mg Injection 15 ml, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, consult a doctor. Do not discontinue any medications without a doctor's advice.
NatalizumabBortezomib
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Coadministration of bortezomib and Tysabri 300 mg Injection 15 ml can increase the risk of infections.

How to manage the interaction:
Although using bortezomib and Tysabri 300 mg Injection 15 ml together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain, or burning during urination. Do not stop taking any medications without consulting a doctor.
NatalizumabPrednisolone
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Co-administration of Prednisolone with Tysabri 300 mg Injection 15 ml can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Prednisolone with Tysabri 300 mg Injection 15 ml can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, discomfort or burning when you urinate, weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory, and personality, consult a doctor. Do not stop using any medications without a doctor's advice.
NatalizumabBusulfan
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Taking these two medications may raise the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Busulfan and Tysabri 300 mg Injection 15 ml, you can take these medicines together if prescribed by your doctor. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, weakness on one side of the body, clumsiness, vision problems, or confusion. If you experience any of these symptoms, contact your doctor right away. Do not stop using any medications without talking to your doctor.
NatalizumabDasatinib
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Using Tysabri 300 mg Injection 15 ml together with Dasatinib may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Tysabri 300 mg Injection 15 ml and Dasatinib, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - fever, muscle aches, difficulty breathing, pain or burning while urinating - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
NatalizumabBosutinib
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Coadministration of bosutinib with Tysabri 300 mg Injection 15 ml can increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction between bosutinib and Tysabri 300 mg Injection 15 ml, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
NatalizumabTriamcinolone
Severe
How does the drug interact with Tysabri 300 mg Injection 15 ml:
Combining Triamcinolone with Tysabri 300 mg Injection 15 ml can increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Triamcinolone and Tysabri 300 mg Injection 15 ml, but it can be taken if prescribed by a doctor. However, If you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor right away. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • INFLIXIMAB
  • ETANERCEPT
  • ADALIMUMAB
  • GOLIMUMAB
  • GLATIRAMER
  • INTERFERON BETA 1A
  • DOXORUBICIN
  • EPIRUBICIN
  • MERCAPTOPURINE
  • METHYLPREDNISOLONE
  • DEXAMETHASONE
  • PREDNISOLONE

Habit Forming

No

Special Advise

  • It is advised to closely monitor the patient for infections like active tuberculosis, and HIV infection during and after the treatment.
  • It is essential to inform your doctor if you have any active viral, bacterial, and fungal infections before starting Tysabri 300 mg Injection.
  • Tysabri 300 mg Injection is used to treat the condition but does not cure it.
  • This medicine is administered only once every four weeks by a trained oncologist.
  • Tysabri 300 mg Injection will be only given to patients who have enrolled in to TOUCH program.

Diet & Lifestyle Advise

  • Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help heal faster.
  • Eat more fibre-rich foods such as fruits and vegetables.
  • Eat smaller meals all day and drink small amounts of water throughout the day.
  • If you are intolerant to lactose, lower your intake of milk.
  • Avoid foods high in sugar, fat, and processed foods, as these may cause inflammation.
  • Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.
  • Try to stay active. Choose moderate exercises.
  • Prevent stress by doing meditation or yoga.
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