Uptonin Nasal Spray belongs to groups of medications called hypocalcemic agents, primarily indicated for the treatment of postmenopausal osteoporosis in women more than five years postmenopause when alternative therapies are unsuitable. Post-menopausal osteoporosis is a medical condition that causes thinning and weakening of the bones during/after a menopausal period.

Uptonin Nasal Spray contains Calcitonin, a human hormone that prevents bone breakdown and increases bone density (thickness). Thus it helps to treat osteoporosis in postmenopausal women.

Use Uptonin Nasal Spray as prescribed by the doctor. Uptonin Nasal Spray may cause certain side effects such as hypocalcemia, runny nose, nosebleed, sinus pain, application site reactions such as rhinitis (stuffy nose), epistaxis (nose bleeds) and other nasal symptoms, back pain, arthralgia (Joint pain) and headache. Most of these side effects do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Uptonin Nasal Spray is for intranasal use only, do not inject or take it orally. Before using Uptonin Nasal Spray, inform your doctor of all your medical conditions, sensitivities, and all medications you are using. Uptonin Nasal Spray is intended for post-menopausal women; therefore, Uptonin Nasal Spray should not be recommended for other populations. Avoid drinking alcohol because it affects how the body absorbs calcium and vitamin D, which are essential for good bone formation.

Uptonin Nasal Spray contains Calcitonin, a calcitonin receptor agonist that prevents the loss of bones that happens after menopause and helps to rebuild bones. Calcitonin is a hormone that the C-cells in the thyroid gland produce and release. It opposes the parathyroid hormone's action, helping regulate the blood’s calcium and phosphate levels. Uptonin Nasal Spray works by suppressing the activity of the osteoclasts (cells that break down bone). When the osteoclasts break down bone tissue, the calcium enters the bloodstream. Uptonin Nasal Spray lessens the amount of calcium in the blood by preventing the breakdown of bone. Thereby, Uptonin Nasal Spray strengthens the bones and minimizes the risk of fractures. Uptonin Nasal Spray also seems to decrease the amount of calcium the kidneys can re-absorb, lowering calcium levels further.

Before using Uptonin Nasal Spray, Inform your doctor about all your medical conditions, sensitivities, and all medications you are using. Uptonin Nasal Spray is intended for post-menopausal women; therefore, Uptonin Nasal Spray should not be recommended for other populations. In rare situations, individuals using Uptonin Nasal Spray may be affected with anaphylactic shock (a sudden, severe, life-threatening allergic reaction leading to difficulty breathing); if you encounter it, stop using Uptonin Nasal Spray and contact your doctor immediately.

• Hypocalcemia has been reported. Make sure you get enough calcium and vitamin D, as recommended by the doctor.
• Nasal side effects, including severe ulceration, are possible. Nasal examinations should be done regularly.