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  3. Xylistin 0.5MIU Injection 10 ml

Xylistin 0.5MIU Injection 10 ml, Pack of 1 Injection
Xylistin 0.5MIU Injection 10 ml, Pack of 1 Injection
Xylistin 0.5MIU Injection 10 ml, Pack of 1 Injection
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
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Whats That

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Synonym :

COLISTIN

Composition :

COLISTIMETHATE SODIUM-500000IU

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTI- BACTERIALS

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - XYL0125

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

Xylistin 0.5MIU Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin 0.5MIU Injection destroys the bacteria and successfully treats the infection.

Xylistin 0.5MIU Injection is contraindicated in people with Hypersensitivity to any component in Xylistin 0.5MIU Injection. Besides this, it is also contraindicated to use in people with myasthenia gravis (muscle disorder).

Xylistin 0.5MIU Injection contains Colistimethate Sodium. It is an antibiotic medication used when other drugs or therapy are ineffective. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin 0.5MIU Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

Do not use anti diarrhoeal until the doctor has prescribed you. You can drink plenty of fluids (electrolytes) to avoid dehydration. Besides this, you can also take prebiotics or probiotics to manage diarrhoea as it may help increase the number of good bacteria in the intestine, which aids indigestion.

After taking an antibiotic, you may need to wait up to three hours to eat or drink dairy products, including milk and butter, yoghurt, and cheese. Grapefruit juice and dietary supplements containing minerals like calcium may also work to dampen the effect of antibiotics.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Limit alcohol consumption while on treatment with this medicine as it may worsen drowsiness, dizziness or sleepiness.

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Pregnancy

Caution

Xylistin 0.5MIU Injection should not be used in pregnancy unless necessary. Hence, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Xylistin 0.5MIU Injection.

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Breast Feeding

Caution

Xylistin 0.5MIU Injection should not be used in nursing mothers unless necessary. So, inform your doctor if you are a breastfeeding mother. Your doctor will weigh the benefits and potential risks before prescribing Xylistin 0.5MIU Injection.

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Driving

Caution

You may have side effects like visual disturbances and dizziness after taking Xylistin 0.5MIU Injection that may make you unfit to drive or operate machinery. Hence, do not drive or operate machinery until you are feeling well.

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Liver

Safe if prescribed

Inform your doctor before receiving Xylistin 0.5MIU Injection if you have a liver impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Caution should be exercised while using Xylistin 0.5MIU Injection in patients with severe kidney disease. Inform your doctor before receiving Xylistin 0.5MIU Injection if you have a kidney impairment/disorder history. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Consult your doctor

Please consult your doctor. Your doctor will decide the dose of this medicine based on the age and condition of your child.

Product Substitutes

Reference

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7692639/#:~:text=Colistin%20essentially%20solubilizes%20the%20bacterial,resulting%20in%20a%20bactericidal%20effect.
  2. https://www.mims.com/india/drug/info/colistin?type=full&mtype=generic#adverse-reactions
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241451/#:~:text=In%201959%2C%20the%20US%20FDA,diarrhoea%20and%20urinary%20tract%20infections.

About Xylistin 0.5MIU Injection

Xylistin 0.5MIU Injection belongs to the class of medications called ‘antibiotics’ used to treat bacterial infections. Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. These harmful bacteria produce chemicals known as toxins, which can damage tissue and make you sick. Symptoms of bacterial infection vary depending on the organ affected by bacteria.

Xylistin 0.5MIU Injection contains Colistimethate Sodium. Colistimethate Sodium effectively solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin 0.5MIU Injection destroys the bacteria and successfully treats the infection.

Xylistin 0.5MIU Injection will be administered by a qualified healthcare professional. Sometimes, you may experience common side effects like injection site reactions, renal damage, visual disturbances, GI disturbances, dizziness, nausea, vomiting and muscle weakness. But these side effects are usually in the initial phase and resolve over time. However, if these side effects persist, let your doctor know.

Before receiving Xylistin 0.5MIU Injection, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Xylistin 0.5MIU Injection can cause blurred vision and dizziness in some people; if this occurs, do not drive or operate tools or machinery. It is recommended not to consume any alcoholic beverages while on treatment with this medicine.

Uses of Xylistin 0.5MIU Injection

Bacterial infections

Medicinal Benefits Mweb

Medicinal Benefits

Xylistin 0.5MIU Injection contains Colistimethate Sodium. Colistimethate Sodium, also known as polymyxin E, is an antibiotic medication used as a last-resort treatment for multidrug-resistant Gram-negative infections. Colistimethate Sodium essentially solubilizes the bacterial cell membrane, resulting in bacterial cell death. As a result, Xylistin 0.5MIU Injection kills the bacteria and effectively treats the infection. In addition, it can also treat infectious diarrhoea and urinary tract infections.

Directions for Use

Xylistin 0.5MIU Injection will be administered by a qualified healthcare professional. Do not self-administer.

Side Effects of Xylistin 0.5MIU Injection

  • Superinfection (reinfection)
  • Renal damage
  • Visual disturbances
  • GI disturbances
  • Dizziness
  • Nausea
  • Vomiting
  • Confusion
  • Peripheral neuropathy
  • Respiratory insufficiency
  • Muscle weakness

Drug Warnings

If you are allergic to Xylistin 0.5MIU Injection, please inform your physician. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or are breastfeeding before receiving Xylistin 0.5MIU Injection. Also, inform your doctor if you have chronic kidney disease, myasthenia gravis (muscle disorder), and porphyria (a blood disorder). Do not abruptly discontinue taking the prescription since this may result in antibiotic resistance, a condition in which bacteria develop resistance to antibiotics.

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
ColistinPipecuronium bromide
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Coadministration of Xylistin 0.5MIU Injection 10 ml along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Xylistin 0.5MIU Injection 10 ml with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinPipecuronium bromide
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Coadministration of Pipecuronium bromide with Xylistin 0.5MIU Injection 10 ml may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and pipecuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinPancuronium
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Using Pancuronium with Xylistin 0.5MIU Injection 10 ml can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Pancuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinAtracurium
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Coadministration of Atracurium with Xylistin 0.5MIU Injection 10 ml can increase the risk of Atracurium side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Atracurium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinTenofovir alafenamide
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Combining Xylistin 0.5MIU Injection 10 ml with Tenofovir alafenamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Tenofovir alafenamide, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience an upset stomach, rash, dizziness, or fever. Do not stop using any medications without a doctor's advice.
ColistinHuman immunoglobulin
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Taking Human immunoglobulin with Xylistin 0.5MIU Injection 10 ml, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Human immunoglobulin and Xylistin 0.5MIU Injection 10 ml, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinAdefovir dipivoxil
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Combining Xylistin 0.5MIU Injection 10 ml with Adefovir dipivoxil may decrease Xylistin 0.5MIU Injection 10 ml's excretion rate, which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Adefovir dipivoxil, you can take these medicines together if prescribed by your doctor. However, if you experience any irregular urination, swelling, shortness of breath, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinKanamycin
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Coadministration of Xylistin 0.5MIU Injection 10 ml with Kanamycin can increase the level and risk of Xylistin 0.5MIU Injection 10 ml side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Kanamycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, swelling, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinEverolimus
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Coadministration of Xylistin 0.5MIU Injection 10 ml with Everolimus can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Everolimus, it can be taken if prescribed by a doctor. However, if you experience vomiting, irregular urination, sudden weight gain or loss, swelling, shortness of breath, or weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinStreptomycin
Severe
How does the drug interact with Xylistin 0.5MIU Injection 10 ml:
Coadministration of Streptomycin with Xylistin 0.5MIU Injection 10 ml may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Xylistin 0.5MIU Injection 10 ml and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CYCLOBENZAPRINE
  • METAXALONE
  • AMPHOTERICIN B
  • CAPREOMYCIN
  • VANCOMYCIN

Habit Forming

No

Special Advise

  • Regular blood tests are required to monitor kidney functions while taking Xylistin 0.5MIU Injection.
  • A Healthcare professional should always give a Xylistin 0.5MIU Injection to a hospital. Never self-administer.

Diet & Lifestyle Advise

  • After taking the full course of Xylistin 0.5MIU Injection, probiotics should be taken to restore some of the healthy bacteria in the intestine that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods like yoghurt, cheese, sauerkraut and kimchi can restore the intestine's good bacteria stink.
  • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria which helps stimulate their growth. Thus fibre foods may help restore healthy gut bacteria after taking a course of antibiotics. Whole grains, like whole-grain bread, and brown rice, should be included in your diet.
  • Avoid taking many calcium-enriched foods and drinks as it might affect the working of Xylistin 0.5MIU Injection.
  • Avoid intake of alcoholic beverages with Xylistin 0.5MIU Injection as it can make you dehydrated and affect your sleep. This can make it harder for your body to aid the Xylistin 0.5MIU Injection in fighting off infections.

Xylistin 0.5MIU Injection Substitute

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