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Reviewed By Sureshvarma D , MPharma
48 Hrs returnable
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Whats That

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Composition :

SAFINAMIDE-50MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIPARKINSON AGENTS

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - ZAF0011

FAQs

Zafimove 50 Tablet works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

Do not double the dosage to compensate for a missed one. One can skip the missed portion and take the next dosage at the standard time of the following day.

Yes, Zafimove 50 Tablet is not recommended in albinism (an inherited condition that causes a lack of colour in the skin, hair and eyes), retinal degeneration, uveitis (inflammation of the middle layer of the eye (uvea)), inherited retinopathy or severe progressive diabetic retinopathy.

Do not stop Zafimove 50 Tablet suddenly; it may cause side effects like confusion, stiff muscles and a high fever. So please consult your doctor before stopping the medicine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Zafimove 50 Tablet may cause excessive drowsiness with alcohol, decreasing alertness and affecting your vision.

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Pregnancy

Unsafe

Zafimove 50 Tablet may be unsafe to use during pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Zafimove 50 Tablet . Please consult your doctor before taking Zafimove 50 Tablet .

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Breast Feeding

Unsafe

Zafimove 50 Tablet may be unsafe to use in breastfeeding mothers. Your doctor will weigh the benefits and potential risks before prescribing Zafimove 50 Tablet . Please consult your doctor before taking Zafimove 50 Tablet .

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Driving

Caution

Zafimove 50 Tablet may decrease alertness, affect your vision or make you sleepy and dizzy. Do not drive if these symptoms occur.

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Liver

Caution

Zafimove 50 Tablet should be used with caution in patients with liver disease. A dose adjustment of Zafimove 50 Tablet may be needed. So please consult your doctor before taking Zafimove 50 Tablet .

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Kidney

Caution

Zafimove 50 Tablet should be used with caution in patients with kidney disease. A dose adjustment of Zafimove 50 Tablet may be needed. So please consult your doctor before taking Zafimove 50 Tablet .

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Children

Unsafe

Zafimove 50 Tablet is not recommended for use in children under 12 years.

About Zafimove 50 Tablet

Zafimove 50 Tablet belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. Parkinson’s disease is a disorder of the central nervous system that affects movement and locomotion. It causes stiffness, shaking, and difficulty in walking, coordination and balance. 

Zafimove 50 Tablet contains 'safinamide', belonging to the group of medications called monoamine oxidase type B (MAO-B) inhibitors. It works by increasing the amount of dopamine (a natural substance that is needed to control movement) in the brain.

Zafimove 50 Tablet may cause common side effects like cough, depression, indigestion, flu-like symptoms, insomnia (difficulty sleeping), joint pain, and peripheral oedema. Most of these side effects of  Zafimove 50 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Zafimove 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Zafimove 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Zafimove 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Zafimove 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Zafimove 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants, or opioid drugs.

Uses of Zafimove 50 Tablet

Parkinson's disease

Medicinal Benefits Mweb

Medicinal Benefits

Zafimove 50 Tablet belongs to a class of drugs called antiparkinson agents, which are used in combination with other drugs for the treatment of the signs and symptoms of Parkinson's disease. It works by increasing the amount of dopamine (a natural substance needed to control movement) in the brain. Thereby improving the symptoms of Parkinson’s disease.

Directions for Use

Swallow Zafimove 50 Tablet as a whole with water. Do not chew, crush or break it.

Side Effects of Zafimove 50 Tablet

  • Cough
  • Depression
  • Indigestion
  • Flu-like symptoms
  • Insomnia (difficulty in sleeping)
  • Joint pain
  • Peripheral oedema

Drug Warnings

If you are known to be allergic to Zafimove 50 Tablet or any other medicines, please tell your doctor. Please inform your doctor if you are using any medications other than Zafimove 50 Tablet . If you are pregnant or breastfeeding, it is advised to inform your doctor. Zafimove 50 Tablet is not recommended in albinism, retinal degeneration, uveitis, inherited retinopathy or severe progressive diabetic retinopathy. Zafimove 50 Tablet should be used with caution in patients like schizophrenia (a mental illness that causes disturbed thinking, loss of interest in life, and strong or unusual emotions), bipolar disorder (mood that changes from depressed to abnormally excited), or psychosis; or if you have high or low blood pressure; dyskinesia (abnormal movements); or sleep problems. Zafimove 50 Tablet should be used caution with liver diseases. Zafimove 50 Tablet may cause serotonin syndrome when used with MAO inhibitors, antidepressants or opioid drugs. A combination of MAOIs and dextromethorphan has been reported to cause episodes of psychosis or abnormal behaviour.

Drug-Drug Interactions

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SafinamideMaprotiline
Critical

Drug-Drug Interactions

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How does the drug interact with Zafimove 50 Tablet:
Taking Zafimove 50 Tablet with Trimipramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 50 Tablet with Trimipramine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideMaprotiline
Critical
How does the drug interact with Zafimove 50 Tablet:
Taking Zafimove 50 Tablet with Maprotiline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 50 Tablet with Maprotiline is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 50 Tablet:
Coadministration of Nortriptyline with Zafimove 50 Tablet may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Nortriptyline with Zafimove 50 Tablet together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 50 Tablet:
Taking Procarbazine with Zafimove 50 Tablet can increase the risk of hypertension(High BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 50 Tablet with Procarbazine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamidePhenelzine
Critical
How does the drug interact with Zafimove 50 Tablet:
Taking Phenelzine with Zafimove 50 Tablet can increase the risk of hypertension(high BP) and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 50 Tablet with Phenelzine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 50 Tablet:
Taking Zafimove 50 Tablet with levomilnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Zafimove 50 Tablet with levomilnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Zafimove 50 Tablet:
Taking Zafimove 50 Tablet and Methyldopa together can increase the risk of high blood pressure or brain related problems.

How to manage the interaction:
Taking Zafimove 50 Tablet with Methyldopa is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately If you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Zafimove 50 Tablet:
Using Amitriptyline together with Zafimove 50 Tablet can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Zafimove 50 Tablet and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SafinamideLisdexamfetamine
Critical
How does the drug interact with Zafimove 50 Tablet:
Taking Zafimove 50 Tablet with Lisdexamfetamine may raise blood pressure and increased heart rate.

How to manage the interaction:
Taking Zafimove 50 Tablet with Lisdexamfetamine is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms like headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat, consult a doctor. Do not stop using any medications without first talking to your doctor.
SafinamideDexmethylphenidate
Critical
How does the drug interact with Zafimove 50 Tablet:
Taking Zafimove 50 Tablet with Dexmethylphenidate together may increase side effects such as blood pressure elevations and increased heart rate.

How to manage the interaction:
Taking Zafimove 50 Tablet with Dexmethylphenidate is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms like headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Zafimove 50 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Zafimove 50 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DICLOFENAC
  • TRAMADOL
  • FLUOXETINE
  • BUPROPION
  • AMITRIPTYLINE
  • BALOFLOXACIN
  • CIPROFLOXACIN
  • CARBAMAZEPINE
  • ROSUVASTATIN
  • PITAVASTATIN
  • PRAVASTATIN
  • METHOTREXATE
  • GLYBURIDE
  • MEPERIDINE
  • METHADONE
  • PROPOXYPHENE
  • ISOCARBOXAZID
  • LINEZOLID
  • METHYLENE BLUE
  • MOCLOBEMIDE
  • PHENELZINE
  • PROCARBAZINE
  • RASAGILINE
  • SELEGILINE
  • TRANYLCYPROMINE
  • DEXTROMETHORPHAN
  • TOPOTECAN

Habit Forming

No

Special Advise

  • Talk to your doctor if you develop hallucinations or other changes in your behaviour.

Diet & Lifestyle Advise

  • A balanced diet is essential to show improvement in Parkinson's disease, including grains and leafy foods, as this food is rich in vitamins, fibres, and minerals. With this food, one should also include dairy items, protein-rich nourishments, for example, meat and beans, and solid fats found in nuts, olive oil, fish, and eggs in their diet. However, limit the consumption of sugar.
  • Avoid intake of high-protein foods like soy protein, fish, eggs, chicken, beef, and pork. Eat more whole-grain foods such as whole wheat bread, oatmeal, brown rice or pasta.
  • Eat more fibre-rich foods to ease constipation.
  • Drink plenty of water to avoid headaches due to dehydration.
  • Avoid the consumption of alcohol as it may increase drowsiness.

Zafimove 50 Tablet Substitute

Always consult your doctor before taking any new medications and supplements

  • Xafinact 50 Tablet 10's

    by AYUR

    16.02per tablet
  • Safion 50 Tablet 10's

    by Others

    14.04per tablet

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