Zenace MR 300mg/4mg Tablet belongs to a group of medicines called analgesics used to treat osteoarthritis, rheumatoid arthritis, pain, and muscle spasms. Osteoarthritis is a degenerative joint disease in which the two ends of the joints come together due to the breakdown of a protective covering (cartilage). Due to the absence of this protective covering, the joints rub against each other, leading to pain and stiffness. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue), leading to joint pain and damage.
 
Zenace MR 300mg/4mg Tablet is a combination of two drugs, namely: Etodolac (NSAID) and Thiocolchicoside (Muscle relaxant). Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes other chemical prostaglandins. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helps relieve pain due to muscle spasms.
 
You are advised to take Zenace MR 300mg/4mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Zenace MR 300mg/4mg Tablet may cause common side effects such as nausea, vomiting, heartburn, stomach pain, and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Consult your doctor if you are pregnant or breastfeeding. Zenace MR 300mg/4mg Tablet may cause drowsiness and dizziness, so drive with caution. Zenace MR 300mg/4mg Tablet is not recommended for children as safety and efficacy have not been established. Avoid consuming alcohol along with Zenace MR 300mg/4mg Tablet as it could lead to increased dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and medicines to rule out any side effects/interactions.

Zenace MR 300mg/4mg Tablet is a combination of two drugs: Etodolac (Non-Steroidal Anti-Inflammatory Drugs) and Thiocolchicoside (Muscle relaxant). Zenace MR 300mg/4mg Tablet is used to treat osteoarthritis, rheumatoid arthritis, pain, and muscle spasms. Etodolac blocks the effect of a chemical messenger known as cyclo-oxygenase (COX) enzyme that makes another chemical, prostaglandins, which are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser prostaglandins are produced. This helps reduce mild to moderate pain and inflammation at the injured or damaged site. Thiocolchicoside works on the centres of the spinal cord and brain. This helps relieve muscle stiffness and improves muscle movements, thereby helping relieve pain due to muscle spasms.

Do not take Zenace MR 300mg/4mg Tablet if you are allergic to any of its contents; if you have stomach ulcers, bleeding problems, clotting problems, inflammatory bowel disease, severe heart, liver or kidney problems, galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Inform your doctor if you have/had stomach bleeding or ulcers, heart failure, high blood pressure, diabetes, high cholesterol, kidney or liver impairment. Consult your doctor if you are pregnant or breastfeeding. Zenace MR 300mg/4mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Zenace MR 300mg/4mg Tablet is not recommended for children as safety has not been established. Stop taking Zenace MR 300mg/4mg Tablet and consult your doctor immediately if you have stomach pain or any signs of bleeding in the intestine or stomach, such as blood in stools. Do not take any other NSAIDs for pain relief along with Zenace MR 300mg/4mg Tablet unless prescribed.