Before taking Loxheal Crea, tell your doctor if you are hypersensitive to it. Before using this medicine, discuss your medical history, particularly if you have broken skin/infection in the area where the drug is to be applied or if you have heart disease, liver disease, or kidney disorder. Do not use this medication more frequently or in larger doses than suggested, as it is absorbed through the skin and might have serious negative effects.

Loxheal Crea consists of two drugs, namely Lidocaine and Nifedipine. Lidocaine belongs to the class of local anaesthesia and is used to diminish inconvenience or pain associated with anal fissures. Being a sedative, it works by causing temporary loss of sensation in the anal region. It does so by blocking both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions, further reducing depolarization with the resultant blockade of conduction. This way, the person gets relief from the pain associated with rectal discomfort. While Nifedipine works by relaxing the smooth muscles around the anus and promoting the blood in the anal area that helps heal the anal fissure faster. Nifedipine also blocks the action of calcium on the blood vessels of the anus. These actions reduce anal canal pressure, relieving pain and spasm. In this way, the Loxheal Crea helps in healing anal fissures.
 

Loxheal Crea is a combination of two different drugs, namely Lidocaine (local anaesthetic) and Nifedipine (calcium channel blocker), used in the treatment of Anal fissure (tear in the lining of the anus). An anal fissure is usually a small tear or cut in the lining of the anus. This crack in the skin is responsible for causing extreme pain and bleeding during and after bowel movements. Sometimes these fissures can be deep enough to cause spasms in the anal sphincter, which is the end part of the anus. A person dealing with anal fissures may experience pain during/ after a bowel movement, bleeding during the stool, and a visible crack around the anus area.

Lidocaine is a local anaesthetic. It blocks pain signals from the nerves to the brain, decreasing the pain sensation. Nifedipine is a calcium channel blocker (CCB). It works in anal fissures by blocking the action of calcium on the blood vessels of the anus. Altogether the Loxheal Crea works by relaxing the smooth muscles around the anus area and promoting the proper blood flow in that region that helps to heal the fissure quickly. Loxheal Crea also reduces the anal canal pressure, which diminishes the pain and spasm in the anal region.

Loxheal Crea should be applied inside the rectum area as suggested by the doctor with the help of a rectal applicator given with the medication. Gently insert the applicator tip, just 1/2 to 1 inch consisting of medication, into the rectum and squeeze the tube to deliver the drug before taking it out. Before using this medicine, clean the affected area with gentle soap and water, and pat dry. Use the applicator for single use and discard it after every use. Never re-use it and use it regularly at the same time each day. Many persons using this drug does not face any side effect; however, possible side effects of Loxheal Crea may include burning, itching, redness, irritation, etc. However, if a person notices rectal bleeding, skin redness, or any other serious side effects, they need medical help immediately. 

The usage of Loxheal Crea is not allowed in patients who are hypersensitive to any of the components present in it as it may cause serious side effects. Before starting the medication, tell your doctor about your medical history, especially if you have broken skin/infection in the area where Loxheal Crea is to be applied, heart disease, liver disease, or a certain blood disorder (methemoglobinemia). Inform your doctor before taking Loxheal Crea if you plan to get pregnant, are pregnant, or breastfeeding.

• Redness Of The Skin
• Itching
• Rash
• Irritation
• Swelling