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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Composition :

FOSAPREPITANT-150MG

Manufacturer/Marketer :

Axiommax Oncology Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

Other Info - APR0134

Author Details

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About Aprifast 150 mg Injection

Uses of Aprifast 150 mg Injection

Medicinal Benefits Mweb

Key Benefits

Directions for Use

Side Effects of Aprifast 150 mg Injection

Drug Warnings

Drug-Drug Interactions

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AprepitantFlibanserin
Critical

Drug-Drug Interactions

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How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Aprifast 150 mg Injection and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Aprifast 150 mg Injection:
Using flibanserin together with Aprifast 150 mg Injection can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Aprifast 150 mg Injection together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Aprifast 150 mg Injection:
Aprifast 150 mg Injection combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantTerfenadine
Critical
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantAstemizole
Critical
How does the drug interact with Aprifast 150 mg Injection:
Co-administration with Aprifast 150 mg Injection and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Aprifast 150 mg Injection and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
How does the drug interact with Aprifast 150 mg Injection:
Using pimozide together with Aprifast 150 mg Injection may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Aprifast 150 mg Injection and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Aprifast 150 mg Injection:
Lomitapide blood levels can be significantly increased by combining it with Aprifast 150 mg Injection.

How to manage the interaction:
Although using Lomitapide and Aprifast 150 mg Injection together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AprepitantNaloxegol
Severe
How does the drug interact with Aprifast 150 mg Injection:
Coadministration of Aprifast 150 mg Injection with Naloxegol the blood levels of Naloxegol may significantly increase.

How to manage the interaction:
Although there is an interaction between Aprifast 150 mg Injection and naloxegol, it can be taken if prescribed by a doctor. If you have a lot of sweating, tears, a runny nose, chills, diarrhea, abdominal pain, nervousness, sleeplessness, irritability, restlessness, or a lot of yawning, consult a doctor. Without consulting a doctor, never stop taking medicines.
How does the drug interact with Aprifast 150 mg Injection:
Aprifast 150 mg Injection may significantly raise olaparib levels in the blood. This has a tendency to intensify side effects.

How to manage the interaction:
Despite the fact that Aprifast 150 mg Injection and naloxegol interact, it can be taken if prescribed by a doctor. If you have paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or pain while urinating , consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Aprifast 150 mg Injection:
When used with bromocriptine, Aprifast 150 mg Injection may raise blood levels of bromocriptine.

How to manage the interaction:
Although co-administration of Aprifast 150 mg Injection and bromocriptine may result in an interaction, it can be used if prescribed by a doctor. Consult a doctor if you have any of the following symptoms: nausea, headache, dizziness, drowsiness, lightheadedness, or compulsive behaviors (e.g., gambling or sexual urges; uncontrolled spending). Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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FOSAPREPITANT-150MGAlcoholic liver disease
Moderate

Drug-Diseases Interactions

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FOSAPREPITANT-150MGAlcoholic liver disease
Moderate
How does the disease interact with Aprifast 150 mg Injection:
The liver is primarily responsible for Aprifast 150 mg Injection metabolism. Aprifast 150 mg Injection was well tolerated in investigations of patients with mild to moderate hepatic impairment (Child-Pugh score 5 to 9), and no clinically significant changes in its pharmacokinetics were seen. As a result, there is no need to change the dosage of Aprifast 150 mg Injection in this patient population. Aprifast 150 mg Injection should be used with caution in patients with severe hepatic impairment (Child-Pugh score > 9), as there is no clinical or pharmacokinetic data in this population.

How to manage the interaction:
Aprifast 150 mg Injection is metabolized by the liver, hence it is usually not recommended in patients with mild to moderate liver disease as it can increase the Aprifast 150 mg Injection level in the body. Increased levels can increase the risk and severity of Aprifast 150 mg Injection side effects. However, you can take it when advised by your doctor. If you experience headache, fatigue, low appetite, constipation, diarrhea, nausea, and hiccups contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

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