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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

APREPITANT-150MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIEMETICS

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - APR0085

Author Details

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FAQs

Apriset Iv Inj works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines.

Apriset Iv Inj may cause weakness as a common side effect. However, if the weakness persists or worsens, consult your doctor.

You are advised not to take hormonal birth control medicines such as birth control pills, implants, skin patches, and certain Intrauterine devices (IUDs) as they may not work properly when taken together with Apriset Iv Inj. Therefore, you are recommended to use another or additional non-hormonal form of birth control method during treatment with Apriset Iv Inj and for up to 1 month after using Apriset Iv Inj.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Consult your doctor

The interaction of alcohol with Apriset Iv Inj is unknown. If you have any concerns regarding this, please discuss them with your doctor.

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Pregnancy

Consult your doctor

If you are pregnant or planning pregnancy, inform your doctor before taking Apriset Iv Inj. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Consult your doctor

It is unknown whether Aprepitant is excreted in breast milk. Hence, if you are a nursing mother, inform your doctor before receiving Apriset Iv Inj.

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Driving

Caution

Drive only if you are alert after receiving Apriset Iv Inj.

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Liver

Caution

If you have liver disease, inform your doctor before taking Apriset Iv Inj.

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Kidney

Consult your doctor

If you have any kidney problems, inform your doctor before taking Apriset Iv Inj.

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Children

Caution

Apriset Iv Inj is not recommended for children below six months of age as the safety and effectiveness are unknown.

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Keep Refrigerated. Do not freeze.Prepaid payment required.

About Apriset Iv Inj

Apriset Iv Inj belongs to a class of drugs called anti-emetics. It is used in combination with other medicines to prevent nausea and vomiting caused by chemotherapy (anti-cancer medicines) in patients six months of age and above. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Apriset Iv Inj contains Aprepitant, a neurokinin 1 (NK1) receptor antagonist which works by blocking neurokinin-1 receptors (causes the feeling of sickness) present in the vomiting centre in the brain. Thus, it helps prevent nausea and vomiting. 

Apriset Iv Inj will be administered by a healthcare professional; do not self-administer. In some cases, Apriset Iv Inj may cause common side effects such as weakness, tiredness, diarrhoea, urinary tract infection, pain in arms and legs, or indigestion. Most of these side effects do not require medical attention and gradually resolve over time. However, consult your doctor immediately if the side effects persist or worsen. 

If you are allergic to Apriset Iv Inj or any other medicines, please tell your doctor. Apriset Iv Inj is not recommended for children below six months of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apriset Iv Inj. Drive only if you are alert after receiving Apriset Iv Inj. If you are taking other prescription or non-prescription medicines, inform your doctor before taking Apriset Iv Inj. 

Uses of Apriset Iv Inj

Chemotherapy-induced nausea and vomiting

Medicinal Benefits Mweb

Medicinal Benefits

Apriset Iv Inj contains Aprepitant, an anti-emetic (a drug used to treat nausea and vomiting) that works by blocking the action of a natural substance in the brain called neurokinin that causes nausea and vomiting. Thus, it is used in combination with other medicines to prevent nausea and vomiting caused by anti-cancer medicines in patients six months of age and above.

Directions for Use

Apriset Iv Inj will be administered by a healthcare professional; do not self-administer.

Side Effects of Apriset Iv Inj

  • Weakness
  • Tiredness
  • Diarrhoea
  • Urinary tract infection
  • Pain in arms and legs
  • Indigestion

Drug Warnings

If you are allergic to Apriset Iv Inj or any other medicines, please tell your doctor. Apriset Iv Inj is not recommended for children below 6 months of age. If you are pregnant or breastfeeding, please inform your doctor before taking Apriset Iv Inj. Drive only if you are alert after receiving Apriset Iv Inj. If you are taking any other prescription or non-prescription medicines, inform your doctor before taking Apriset Iv Inj. If you are using warfarin (blood thinner), your doctor may recommend blood tests after you receive Apriset Iv Inj to check your blood clotting.

Drug-Drug Interactions

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AprepitantAstemizole
Critical

Drug-Drug Interactions

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AprepitantAstemizole
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Astemizole may increase the blood levels of Astemizole.

How to manage the interaction:
Although taking Apriset Iv Inj and Astemizole together is not recommended as it can lead to an interaction, it is safe if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor. Astemizole should not be combined with any other medications without a doctor's advice.
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Cisapride may cause irregular heart rhythm.

How to manage the interaction:
Although taking Apriset Iv Inj and Cisapride together is not recommended as it can lead to an interaction, it is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
AprepitantTerfenadine
Critical
How does the drug interact with Apriset Iv Inj:
Co-administration with Apriset Iv Inj and Terfenadine may increase the blood levels of Terfenadine and leads to irregular heartbeat.

How to manage the interaction:
Taking Apriset Iv Inj and Terfenadine together is not recommended as it can lead to an interaction. It is safe to do so if your doctor has prescribed it. Contact a doctor if you have palpitations, an irregular pulse, sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not stop taking any medications without visiting a doctor.
How does the drug interact with Apriset Iv Inj:
Using pimozide together with Apriset Iv Inj may significantly increase the blood levels of pimozide. High blood levels of pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Apriset Iv Inj and Pimozide together is not recommended; as it can lead to an interaction, you can take them if your doctor advises you to. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, get immediate medical help. Do not discontinue any medications without consulting a doctor.
AprepitantEliglustat
Critical
How does the drug interact with Apriset Iv Inj:
Apriset Iv Inj combined with Eliglustat can considerably raise blood levels of Eliglustat. This raises the possibility of cardiac adverse effects such as abnormal heart rhythm, heart block, and cardiac arrest.

How to manage the interaction:
Taking Apriset Iv Inj and Eliglustat together is not recommended as it can lead to an interaction; they can be consumed if prescribed by a doctor. Consult a doctor if you have symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, weak heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AprepitantFlibanserin
Critical
How does the drug interact with Apriset Iv Inj:
Using flibanserin together with Apriset Iv Inj can significantly increase the blood levels of flibanserin.

How to manage the interaction:
Taking Flibanserin and Apriset Iv Inj together is not recommended as it can lead to an interaction; they can be taken if prescribed by a doctor. Consult a doctor if you develop any symptoms, such as extreme sleepiness or low blood pressure, that cause dizziness, lightheadedness, or fainting. To reduce the chance of these side effects, use Flibanserin at bedtime. Do not discontinue any medications without consulting a doctor.
AprepitantLomitapide
Critical
How does the drug interact with Apriset Iv Inj:
Lomitapide blood levels can be significantly increased by combining it with Apriset Iv Inj.

How to manage the interaction:
Although using Lomitapide and Apriset Iv Inj together may cause an interaction, they can be taken if advised by a doctor. Consult a doctor if you have any of the following symptoms: diarrhea, nausea, vomiting, stomach pain or discomfort, indigestion, gas, constipation, liver problems causing fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, dark colored urine, light-colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Apriset Iv Inj:
Using Lurasidone together with Apriset Iv Inj may result in significantly higher Lurasidone blood levels. This may increase the possibility of negative effects like Parkinson's disease. (It is a brain disorder that produces uncontrollable movements.)

How to manage the interaction:
While Lurasidone and Apriset Iv Inj may interact, they can be used if prescribed by a doctor. Consult a doctor if you have any abnormal muscle activity, fits, high blood sugar, high sugars, high cholesterol, heat intolerance or heat stroke, dizziness, lightheadedness, headache, flushing, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Apriset Iv Inj:
Coadministration of fentanyl and Apriset Iv Inj may significantly increase the blood levels and effects of fentanyl.

How to manage the interaction:
Although co-administration of Apriset Iv Inj and Fentanyl can lead to an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, excessive drowsiness, or difficulty breathing. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Apriset Iv Inj:
Co-administartion of Apriset Iv Inj and Ivabradine may significantly increase the blood levels of Ivabradine which can result in excessive slowing of heart rate or other side effects.

How to manage the interaction:
Although there is an interaction between Apriset Iv Inj and Ivabradine, it can be taken if prescribed by a doctor. If you have dizziness, tiredness, low blood pressure, heart palpitations, chest pain, or worsening shortness of breath, you should see a doctor. Without consulting a doctor, never stop taking medicines.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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APREPITANT-150MGAlcoholic liver disease
Moderate

Drug-Diseases Interactions

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APREPITANT-150MGAlcoholic liver disease
Moderate
How does the disease interact with Apriset Iv Inj:
The liver is primarily responsible for Apriset Iv Inj metabolism. Apriset Iv Inj was well tolerated in investigations of patients with mild to moderate hepatic impairment (Child-Pugh score 5 to 9), and no clinically significant changes in its pharmacokinetics were seen. As a result, there is no need to change the dosage of Apriset Iv Inj in this patient population. Apriset Iv Inj should be used with caution in patients with severe hepatic impairment (Child-Pugh score > 9), as there is no clinical or pharmacokinetic data in this population.

How to manage the interaction:
Apriset Iv Inj is metabolized by the liver, hence it is usually not recommended in patients with mild to moderate liver disease as it can increase the Apriset Iv Inj level in the body. Increased levels can increase the risk and severity of Apriset Iv Inj side effects. However, you can take it when advised by your doctor. If you experience headache, fatigue, low appetite, constipation, diarrhea, nausea, and hiccups contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Drug Interactions Checker List

  • PIMOZIDE

Habit Forming

No

Diet & Lifestyle Advise

  • Eat a healthy and low-fat diet that includes lots of fruits and vegetables, skinless poultry, lean meats, nuts, fish, whole grains, and plant-based oils, especially in small portions, as it will be easy for digestion.
  • Avoid eating over-sweet food and include more salty food, especially if you have been vomiting. 
  • Increase the intake of fluids. Drink a small amount of water after small intervals to stay hydrated. 
  • Avoid taking greasy or oily foods, as these foods trigger nausea and vomiting. 
  • If the smell of food makes you feel sick (vomit), do not cook food, as it may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.

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