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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

AXITINIB-5MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - AXZ0002

FAQs

Axzyb Tablet contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Axzyb Tablet is safe to be taken by a diabetic person. However, take Axzyb Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.

Axzyb Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Limit alcohol consumption while taking Axzyb Tablet .

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Pregnancy

Unsafe

Axzyb Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Axzyb Tablet . You should not become pregnant while you are taking Axzyb Tablet . Using effective birth control methods while on treatment with Axzyb Tablet is suggested.

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Breast Feeding

Caution

It is not known whether Axzyb Tablet passes into breastmilk. Hence, if you are breastfeeding, inform your doctor before taking Axzyb Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Axzyb Tablet may cause dizziness and visual disturbances in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with Axzyb Tablet .

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Axzyb Tablet is known to cause elevated liver enzymes, which may be fatal. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Axzyb Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Axzyb Tablet is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

About Axzyb Tablet

Axzyb Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Axzyb Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Axzyb Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Axzyb Tablet should be taken as advised by your doctor.

Avoid taking Axzyb Tablet if you are allergic to it or any other components of it. Before taking Axzyb Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Axzyb Tablet

Renal Cell Carcinoma.

Medicinal Benefits Mweb

Medicinal Benefits

Axzyb Tablet contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Axzyb Tablet stops the body's production, spread and growth of cancerous cells.

Directions for Use

Take Axzyb Tablet as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Side Effects of Axzyb Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Skin rash
  • Increased blood pressure
  • Cough
  • Tiredness
  • Visual disturbances
  • Chest pain
  • Dizziness
  • Weakness
  • Hoarseness
  • Peeling of the skin.

Drug Warnings

To treat your condition effectually, continue taking Axzyb Tablet for the period that your doctor has prescribed. Avoid taking Axzyb Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Axzyb Tablet may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Axzyb Tablet .

Drug-Drug Interactions

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AxitinibPosaconazole
Severe
AxitinibFosamprenavir
Severe

Drug-Drug Interactions

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AxitinibPosaconazole
Severe
How does the drug interact with Axzyb Tablet:
Taking Axzyb Tablet with posaconazole can increase the blood levels of Axzyb Tablet. This may raise the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole and Axzyb Tablet, they can be taken together if prescribed by a doctor. However, if you experience diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
AxitinibFosamprenavir
Severe
How does the drug interact with Axzyb Tablet:
Co-administration of Axzyb Tablet with fosamprenavir may cause Axzyb Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Axzyb Tablet with Fosamprenavir can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without consulting a doctor.
AxitinibKetoconazole
Severe
How does the drug interact with Axzyb Tablet:
Coadministration of ketoconazole with Axzyb Tablet can increase the levels of Axzyb Tablet in the body. This may increase the risk or severity of side effects.

How to manage the interaction:
Although taking Ketoconazole and Axzyb Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
AxitinibRifabutin
Severe
How does the drug interact with Axzyb Tablet:
Coadministration of Rifabutin may decrease the blood levels of Axzyb Tablet.

How to manage the interaction:
Although taking Axzyb Tablet and Rifabutin together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.
AxitinibClarithromycin
Severe
How does the drug interact with Axzyb Tablet:
Co-administration of Clarithromycin may increase the blood levels of Axzyb Tablet may increase side effects.

How to manage the interaction:
Although there is a possible interaction Clarithromycin can be taken with Axzyb Tablet if prescribed by the doctor. Seek immediate medical attention if you develop chest pain or pressure; coughing up or vomiting blood or blood clots; pain in the arms, back, neck, or jaw; swelling; shortness of breath; numbness or weakness on one side of the body; headache; vision changes; seizures, unusual bleeding or bruising; red or black stools; and severe stomach or abdominal pain. Do not discontinue the medication without consulting a doctor.
AxitinibItraconazole
Severe
How does the drug interact with Axzyb Tablet:
Coadministration of Itraconazole and Axzyb Tablet may significantly increase the blood levels of Axzyb Tablet.

How to manage the interaction:
Axzyb Tablet and itraconazole may interact, but if prescribed by a doctor, they can be used together. Any of the following symptoms should be reported: high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling skin on the hands and feet, chest pain, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, fits, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood. Do not stop any medications without consulting a doctor.
AxitinibBoceprevir
Severe
How does the drug interact with Axzyb Tablet:
When Axzyb Tablet and boceprevir are taken together it may considerably raise Axzyb Tablet levels in the blood. This may eventually result in increased side effects.

How to manage the interaction:
Co-administration of Axzyb Tablet with Boceprevir can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain or pressure; pain in the arms, back, neck, or jaw; swelling; shortness of breath; numbness or weakness on one side of the body; headache; vision changes; seizures, unusual bleeding or bruising; red or black stools; coughing up or vomiting blood or blood clots; and severe stomach or abdominal pain, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AxitinibEfavirenz
Severe
How does the drug interact with Axzyb Tablet:
Efavirenz may decrease the blood levels of Axzyb Tablet, which may make Axzyb Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Axzyb Tablet and Efavirenz, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
AxitinibSaquinavir
Severe
How does the drug interact with Axzyb Tablet:
When Axzyb Tablet is taken with Saquinavir, the body's ability to break down Axzyb Tablet may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Axzyb Tablet and Saquinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibCarbamazepine
Severe
How does the drug interact with Axzyb Tablet:
Taking carbamazepine and Axzyb Tablet together can reduce the effects of Axzyb Tablet, which may make medication less effective in treating your condition.

How to manage the interaction:
Taking carbamazepine and Axzyb Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Axzyb Tablet.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • DILTIAZEM
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • DEXAMETHASONE

Habit Forming

No

Special Advise

  • Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of Axzyb Tablet .
  • It is advised to use contraceptive pills while using Axzyb Tablet to prevent pregnancy.
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Axzyb Tablet Substitute

Substitutes safety advice
  • Axpero 5 mg Tablet 14's

    by AYUR

    141.08per tablet
  • INLYTA 5MG TABLETLET 14'S

    by Others

    2623.47per tablet
  • Bexinib 5mg Tablet 14's

    by Others

    357.58per tablet
  • Aximac 5 mg Tablet 14's

    by Others

    2213.18per tablet
  • Axilieva 5 mg Tablet 28's

    by Others

    116.85per tablet
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