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  3. Tykinax 5 Tablet 14's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

AXITINIB-5MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - TYK0004

FAQs

Tykinax 5 Tablet contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Tykinax 5 Tablet is safe to be taken by a diabetic person. However, take Tykinax 5 Tablet only after consulting with a doctor, as they may adjust the dosing according to your condition.

Tykinax 5 Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Disclaimer

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Alcohol

Caution

Limit alcohol consumption while taking Tykinax 5 Tablet .

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Pregnancy

Unsafe

Tykinax 5 Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Tykinax 5 Tablet . You should not become pregnant while you are taking Tykinax 5 Tablet . Using effective birth control methods while on treatment with Tykinax 5 Tablet is suggested.

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Breast Feeding

Caution

It is not known whether Tykinax 5 Tablet passes into breastmilk. Hence, if you are breastfeeding, inform your doctor before taking Tykinax 5 Tablet . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Tykinax 5 Tablet may cause dizziness and visual disturbances in some patients. Hence, do not drive, operate machinery, or engage in any activity that needs clear vision until you are confident that you can do so safely while you are on treatment with Tykinax 5 Tablet .

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Tykinax 5 Tablet is known to cause elevated liver enzymes, which may be fatal. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Tykinax 5 Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Tykinax 5 Tablet is not recommended for use in children below 18 years of age as the safety and efficacy is not established.

About Tykinax 5 Tablet

Tykinax 5 Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Tykinax 5 Tablet contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Tykinax 5 Tablet may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Tykinax 5 Tablet should be taken as advised by your doctor.

Avoid taking Tykinax 5 Tablet if you are allergic to it or any other components of it. Before taking Tykinax 5 Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Tykinax 5 Tablet

Renal Cell Carcinoma.

Medicinal Benefits Mweb

Medicinal Benefits

Tykinax 5 Tablet contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Tykinax 5 Tablet stops the body's production, spread and growth of cancerous cells.

Directions for Use

Take Tykinax 5 Tablet as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Side Effects of Tykinax 5 Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Skin rash
  • Increased blood pressure
  • Cough
  • Tiredness
  • Visual disturbances
  • Chest pain
  • Dizziness
  • Weakness
  • Hoarseness
  • Peeling of the skin.

Drug Warnings

To treat your condition effectually, continue taking Tykinax 5 Tablet for the period that your doctor has prescribed. Avoid taking Tykinax 5 Tablet if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Tykinax 5 Tablet may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Tykinax 5 Tablet .

Drug-Drug Interactions

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AxitinibSaquinavir
Severe

Drug-Drug Interactions

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How does the drug interact with Tykinax 5 Tablet:
Armodafinil may reduce the blood levels of Tykinax 5 Tablet, which may reduce the effect of Tykinax 5 Tablet.

How to manage the interaction:
If you are supposed to take Armodafinil and Tykinax 5 Tablet together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. If your symptoms worsen or your condition changes, contact your doctor.
AxitinibSaquinavir
Severe
How does the drug interact with Tykinax 5 Tablet:
When Tykinax 5 Tablet is taken with Saquinavir, the body's ability to break down Tykinax 5 Tablet may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Tykinax 5 Tablet and Saquinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibFosamprenavir
Severe
How does the drug interact with Tykinax 5 Tablet:
Co-administration of Tykinax 5 Tablet with fosamprenavir may cause Tykinax 5 Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Tykinax 5 Tablet with Fosamprenavir can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Tykinax 5 Tablet:
Phenobarbital can considerably lower Tykinax 5 Tablet levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Tykinax 5 Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
AxitinibDelavirdine
Severe
How does the drug interact with Tykinax 5 Tablet:
Co-administration of Tykinax 5 Tablet with Delavirdine may cause Tykinax 5 Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Tykinax 5 Tablet with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor's advice.
AxitinibMipomersen
Severe
How does the drug interact with Tykinax 5 Tablet:
Co-administration of Tykinax 5 Tablet with mipomersen could elevate the risk of liver issues.

How to manage the interaction:
There may be a possibility of interaction between Tykinax 5 Tablet and Mipomersen, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms, it's important to contact a doctor right away: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, liver damage, or bleeding. Do not stop using any medications without a doctor's advice.
AxitinibConivaptan
Severe
How does the drug interact with Tykinax 5 Tablet:
When Tykinax 5 Tablet is taken with Conivaptan, the breakdown of Tykinax 5 Tablet in the body may be reduced.

How to manage the interaction:
Co-administration of Tykinax 5 Tablet with Conivaptan can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tykinax 5 Tablet:
Coadministration of Modafinil with Tykinax 5 Tablet may decrease the blood levels of Tykinax 5 Tablet, which may make Tykinax 5 Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Tykinax 5 Tablet and Modafinil, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tykinax 5 Tablet:
Taking Tykinax 5 Tablet with ritonavir may significantly increase the blood levels of Tykinax 5 Tablet.

How to manage the interaction:
There may be a possibility of interaction between Tykinax 5 Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Tykinax 5 Tablet:
When Tykinax 5 Tablet is taken with Teriflunomide, the risk of liver problems increases.

How to manage the interaction:
Taking Tykinax 5 Tablet with Teriflunomide together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Tykinax 5 Tablet.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • DILTIAZEM
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • DEXAMETHASONE

Habit Forming

No

Special Advise

  • Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of Tykinax 5 Tablet .
  • It is advised to use contraceptive pills while using Tykinax 5 Tablet to prevent pregnancy.
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

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