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  3. Azalpho Injection

Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

AZACITIDINE-100MG

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Therapeutic Class

CHEMOTHERAPY

Country of origin

India
Other Info - AZ11164

FAQs

Azalpho Injection works by preventing cancer cells from growing. Thereby, it helps treat cancer.

Men should avoid fathering a child whilst on treatment with Azalpho Injection. Consult the doctor if you wish to conserve your sperm before starting the treatment. Use effective contraception during the treatment with Azalpho Injection and for three months after stopping the treatment.

Azalpho Injection may cause a serious immune reaction known as differentiation syndrome. Consult the doctor immediately if you experience fever, rash, difficulty breathing, cough, decreased urine, rapid weight gain, low blood pressure, or swelling of the legs or arms.

Disclaimer

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Alcohol

Consult your doctor

It is not known if alcohol affects Azalpho Injection. Please consult your doctor.

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Pregnancy

Unsafe

Azacitidine belongs to pregnancy category D. Azalpho Injection should not be used during pregnancy as it may harm the baby. Consult the doctor immediately if you become pregnant during treatment with Azalpho Injection.

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Breast Feeding

Unsafe

It is unknown if Azacitidine passes into breast milk. Breastfeeding is not recommended during treatment with Azalpho Injection.

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Driving

Caution

Azalpho Injection may cause dizziness and tiredness. Avoid driving or operating machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

If you have a history of liver disease, inform your doctor before receiving Azalpho Injection. This medicine should be used with caution in patients with severe pre-existing liver impairment.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before receiving Azalpho Injection. Monitoring patients with kidney impairment is advised.

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Children

Unsafe

Azalpho Injection is not recommended for children below 18 years as safety and effectiveness have not been established.

About Azalpho Injection

Azalpho Injection belongs to the group of medicines called anti-metabolites used in adults with higher-risk myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. These conditions affect the bone marrow and could cause problems with normal blood cell production. 
 
Azalpho Injection contains Azacitidine, which works by preventing cancer cells from growing. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.
 
In some cases, Azalpho Injection may cause side effects such as nausea, vomiting, diarrhoea, constipation, weakness, headache, and injection site reactions. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not use Azalpho Injection if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Azalpho Injection. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Azalpho Injection

Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia.

Medicinal Benefits Mweb

Medicinal Benefits

Azalpho Injection belongs to the group of medicines called anti-metabolites used to treat myelodysplastic syndromes, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. Azalpho Injection contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

Directions for Use

Azalpho Injection will be administered by a qualified physician; do not self-administer.

Side Effects of Azalpho Injection

  • Reduced blood count (red blood count, white blood count, and platelets)
  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Tiredness
  • Dizziness
  • Pneumonia
  • Injection site reaction (redness, pain or a skin reaction).

Drug Warnings

Do not use Azalpho Injection if you are allergic to any of its components, have advanced liver cancer, or are breastfeeding. Inform the doctor if you have a low number of platelets, red or white blood cells, heart condition or heart attack, lung, kidney or liver diseases. Seek immediate medical attention if you experience symptoms of liver failure (jaundice, abdominal bloating, shaking, drowsiness, and easy bruising), kidney failure (back pain, increased thirst, swelling of legs and feet, reduced passing of water, dizziness, rapid pulse, nausea, vomiting, reduced appetite, confusion, fatigue or restlessness), fever, pneumonia (shortness of breath or chest pain accompanied with fever), low levels of platelets (bleeding such as blood in stools due to bleeding in the stomach), or allergic reaction (rash, difficulty breathing, itching, or swelling of lips).

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with Azalpho Injection:
Taking Yellow fever vaccine with Azalpho Injection can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Azalpho Injection and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
How does the drug interact with Azalpho Injection:
The use of fingolimod in conjunction with Azalpho Injection may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Azalpho Injection with Fingolimod can possibly result in an interaction, but it can be taken if your doctor has advised it. However, Consult a doctor immediately if you have a fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineEfalizumab
Severe
How does the drug interact with Azalpho Injection:
Using efalizumab together with Azalpho Injection may increase the risk of serious infections.

How to manage the interaction:
Taking Azalpho Injection with Efalizumab together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - complications, infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, pain or burning during urination - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Azalpho Injection:
When Etanercept is used with Azalpho Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Etanercept and Azalpho Injection, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Azalpho Injection:
Using clozapine together with Azalpho Injection can lower white blood cell count and may affect the bone marrow function, that may develop serious infections as a result.

How to manage the interaction:
There may be a possibility of interaction between Azalpho Injection and Clozapine, but it can be taken if prescribed by a doctor. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Azalpho Injection:
Taking Azalpho Injection and leflunomide together may increase the chances of developing severe infections.

How to manage the interaction:
Although there is an interaction between leflunomide and Azalpho Injection, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineBCG vaccine
Severe
How does the drug interact with Azalpho Injection:
Taking BCG vaccine with Azalpho Injection can increase the risk of infection.

How to manage the interaction:
Co-administration of Azalpho Injection with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
How does the drug interact with Azalpho Injection:
Taking thalidomide together with Azalpho Injection may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Azalpho Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Azalpho Injection:
Taking Azalpho Injection with Teriflunomide can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Azalpho Injection and Teriflunomide together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without talking to a doctor.
How does the drug interact with Azalpho Injection:
Taking Adalimumab with Azalpho Injection may raise the risk of severe infections.

How to manage the interaction:
Taking Azalpho Injection with Adalimumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

  • Your doctor will recommend blood tests prior to treatment with Azalpho Injection and at the start of each cycle to check blood cell count, liver and kidney functioning.
  • Women must use reliable contraception during treatment and for six months after receiving the last dose.
  • Male patients are advised to use effective contraception during treatment and for three months after stopping the treatment.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Azalpho Injection.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat a balanced diet.

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