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  3. Bdbrut Capsule 30's

Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

IBRUTINIB-140MG

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CHEMOTHERAPY

Country of origin

India

Manufacturer/Marketer address

407-408, Sharda Chambers, New Marine Lines, Mumbai 400 020 (Maharashtra), New Marine Lines, Marine Lines, Mumbai, Maharashtra 400020
Other Info - BDB0002

FAQs

Bdbrut Capsule works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.

Bdbrut Capsule may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).

Bdbrut Capsule may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.

Disclaimer

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Alcohol

Consult your doctor

It is not known if alcohol affects Bdbrut Capsule . However, avoid consumption of alcohol while on treatment with Bdbrut Capsule as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Bdbrut Capsule should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Bdbrut Capsule .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Bdbrut Capsule .

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Driving

Caution

Bdbrut Capsule may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Bdbrut Capsule if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Bdbrut Capsule .

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Children

Unsafe

Bdbrut Capsule is not recommended for children as safety and effectiveness have not been established.

About Bdbrut Capsule

Bdbrut Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).
 
Bdbrut Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.
 
In some cases, Bdbrut Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not take Bdbrut Capsule if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Bdbrut Capsule . This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Bdbrut Capsule

Mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia.

Medicinal Benefits Mweb

Medicinal Benefits

Bdbrut Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Bdbrut Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. 

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Side Effects of Bdbrut Capsule

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Drug Warnings

Do not take Bdbrut Capsule if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Drug-Drug Interactions

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IbrutinibEpoprostenol
Severe

Drug-Drug Interactions

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How does the drug interact with Bdbrut Capsule:
Co-administration of Bdbrut Capsule with Alteplase can increase the risk of bleeding.

How to manage the interaction:
Taking Bdbrut Capsule with Alteplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
IbrutinibEpoprostenol
Severe
How does the drug interact with Bdbrut Capsule:
Co-administration of Bdbrut Capsule with Epoprostenol can increase the risk of bleeding.

How to manage the interaction:
Taking Bdbrut Capsule with Epoprostenol together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Bdbrut Capsule:
Co-administration of Bdbrut Capsule with Reteplase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Bdbrut Capsule with Reteplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Bdbrut Capsule:
Co-administration of Bdbrut Capsule with Urokinase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Bdbrut Capsule with Urokinase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibIdelalisib
Severe
How does the drug interact with Bdbrut Capsule:
Taking Idelalisib with Bdbrut Capsule may increase the levels of Bdbrut Capsule.

How to manage the interaction:
Although taking Bdbrut Capsule and Idelalisib together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Bdbrut Capsule:
Taking Ticagrelor with Bdbrut Capsule can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Bdbrut Capsule with Ticagrelor together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Bdbrut Capsule:
Co-administration of Bdbrut Capsule with Cabozantinib can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Taking Bdbrut Capsule with Cabozantinib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibEdoxaban
Severe
How does the drug interact with Bdbrut Capsule:
Co-administration of Bdbrut Capsule with Edoxaban can increase the risk of bleeding.

How to manage the interaction:
Taking Bdbrut Capsule with Edoxaban together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Bdbrut Capsule:
Co-administration of Phenytoin and Bdbrut Capsule may decrease the blood levels of Bdbrut Capsule, which may make Bdbrut Capsule less effective.

How to manage the interaction:
Although taking Phenytoin and Bdbrut Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IbrutinibDelavirdine
Severe
How does the drug interact with Bdbrut Capsule:
Taking Delavirdine with Bdbrut Capsule may increase the levels of Bdbrut Capsule.

How to manage the interaction:
Co-administration of Bdbrut Capsule with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Bdbrut Capsule treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Bdbrut Capsule.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Bdbrut Capsule .
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Bdbrut Capsule .

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Have a query?