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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

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Composition :

IBRUTINIB-140MG

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CHEMOTHERAPY

Country of origin

India

Manufacturer/Marketer address

Corporate Communications, Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - IMB0004

FAQs

Imbruvica 140Mg 120 Capsule works by blocking the action of an abnormal protein that helps cancer cells multiply. Thereby, it stops the spread of cancer cells.

Imbruvica 140Mg 120 Capsule may make you bleed more easily. Therefore, consult the doctor if you are taking blood thinner medicines (heparin, warfarin), NSAIDs (aspirin, ibuprofen, naproxen), or supplements that may increase the risk of bleeding (flaxseed, vitamin E, fish oil).

Imbruvica 140Mg 120 Capsule may affect the heart, especially if you already have heart diseases like heart failure, heart rhythm problems, diabetes, high blood pressure, or are of advanced age. Consult the doctor instantly if you experience symptoms of heart failure like breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs.

Disclaimer

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Alcohol

Consult your doctor

It is not known if alcohol affects Imbruvica 140Mg 120 Capsule. However, avoid consumption of alcohol while on treatment with Imbruvica 140Mg 120 Capsule as it may worsen your condition.

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Pregnancy

Unsafe

Ibrutinib belongs to pregnancy category D. Imbruvica 140Mg 120 Capsule should not be used during pregnancy. Use effective contraception and avoid pregnancy during treatment with Imbruvica 140Mg 120 Capsule.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Imbruvica 140Mg 120 Capsule.

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Driving

Caution

Imbruvica 140Mg 120 Capsule may cause dizziness and tiredness. Do not drive or operate machinery if you experience any side effects that might lessen your ability to do so.

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Liver

Caution

Avoid taking Imbruvica 140Mg 120 Capsule if you have moderate or severe baseline liver impairment. Dose adjustment may be needed in patients with mild liver impairment. If you have a history of liver disease, inform the doctor.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before taking Imbruvica 140Mg 120 Capsule.

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Children

Unsafe

Imbruvica 140Mg 120 Capsule is not recommended for children as safety and effectiveness have not been established.

About Imbruvica 140Mg 120 Capsule

Imbruvica 140Mg 120 Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).
 
Imbruvica 140Mg 120 Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.
 
In some cases, Imbruvica 140Mg 120 Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not take Imbruvica 140Mg 120 Capsule if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Imbruvica 140Mg 120 Capsule. This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Imbruvica 140Mg 120 Capsule

Mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia.

Medicinal Benefits Mweb

Medicinal Benefits

Imbruvica 140Mg 120 Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Imbruvica 140Mg 120 Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. 

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Side Effects of Imbruvica 140Mg 120 Capsule

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Drug Warnings

Do not take Imbruvica 140Mg 120 Capsule if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Cilostazol can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Cilostazol together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as unusual bleeding or bruising, dizziness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Cabozantinib can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Cabozantinib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Taking Imbruvica 140Mg 120 Capsule with posaconazole may increase the levels of Imbruvica 140Mg 120 Capsule in the blood.

How to manage the interaction:
Although there is an interaction between posaconazole and Imbruvica 140Mg 120 Capsule, they can be taken together if advised by a doctor. However, contact a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Piroxicam and Imbruvica 140Mg 120 Capsule can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Piroxicam and Imbruvica 140Mg 120 Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Dipyridamole can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Dipyridamole together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
When Imbruvica 140Mg 120 Capsule is taken with Infliximab, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Imbruvica 140Mg 120 Capsule and Infliximab together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
IbrutinibEnzalutamide
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Enzalutamide may decrease the blood levels of Imbruvica 140Mg 120 Capsule, which may make Imbruvica 140Mg 120 Capsule less effective in treating your condition.

How to manage the interaction:
Although taking Enzalutamide and Imbruvica 140Mg 120 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IbrutinibDelavirdine
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Taking Delavirdine with Imbruvica 140Mg 120 Capsule may increase the levels of Imbruvica 140Mg 120 Capsule.

How to manage the interaction:
Co-administration of Imbruvica 140Mg 120 Capsule with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Clozapine can increase the risk of infections.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Clozapine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Heparin can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Imbruvica 140Mg 120 Capsule and Heparin, but it can be taken if prescribed by a doctor. However, consult a doctor, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Imbruvica 140Mg 120 Capsule treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Imbruvica 140Mg 120 Capsule.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Habit Forming

No

Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Imbruvica 140Mg 120 Capsule.
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Imbruvica 140Mg 120 Capsule.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Imbruvica 140Mg 120 Capsule Substitute

Always consult your doctor before taking any new medications and supplements

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