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  3. Bortemib 2 Injection

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Sureshvarma D , MPharma
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

BORTEZOMIB-2MG

Manufacturer/Marketer :

Khandelwal Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Therapeutic Class

CHEMOTHERAPY

Country of origin

India
Other Info - BO13794

Author Details

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FAQs

Bortemib 2 Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells.

Bortemib 2 Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously, or SC). Bortemib 2 Injection must not be administered into your spinal fluid (intrathecally).

Yes, Bortemib 2 Injection can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or believe you have an infection.

Avoid taking Bortemib 2 Injection if you are pregnant because Bortemib 2 Injection can cause harmful effects on the unborn baby. Females should follow effective birth control methods during treatment and at least six months after the final dose of Bortemib 2 Injection.

Before you receive treatment with Bortemib 2 Injection, tell your doctor about all of your medical conditions. You should not receive Bortemib 2 Injection if you are allergic to bortezomib or any contents in Bortemib 2 Injection.

If not given an inappropriate dose, Bortemib 2 Injection can cause toxic effects, although not everyone gets it. So, Bortemib 2 Injection is prescribed by a doctor experienced in using medications to treat cancer only.

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Bortemib 2 Injection. It could lead to avoiding unpleasant side effects.

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Pregnancy

Unsafe

Bortemib 2 Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Bortemib 2 Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Bortemib 2 Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Bortemib 2 Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Bortemib 2 Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have a history or evidence of liver-related diseases, inform the doctor before prescribing the Bortemib 2 Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have a history or evidence of kidney-related diseases, inform the doctor before prescribing the Bortemib 2 Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Bortemib 2 Injection should not be used by children below 18 years of age, as efficacy and safety have not been established.

About Bortemib 2 Injection

Bortemib 2 Injection belongs to a group of anti-cancer medicines used to treat adult patients with multiple myeloma and mantle cell lymphoma who have received at least one prior therapy. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer it affects several areas of the body, such as the spine, skull, pelvis, and ribs. Mantle cell lymphoma (MCL) is a rare type of non-Hodgkin lymphoma (NHL). It develops when B-cells (also called B-lymphocytes) become abnormal. B-cells are white blood cells that fight infection.

Bortemib 2 Injection contains 'Bortezomibx' that works by interfering with how proteasomes work, which may cause cancer cells to die and may stop cancer from growing and eventually kills them.

Bortemib 2 Injection is prescribed by a doctor experienced in the use of medications to treat cancer. It is administered by a healthcare professional as an injection into your vein (intravenously or IV) or under your skin (subcutaneously or SC). Bortemib 2 Injection must not be administered into your spinal fluid (intrathecally). You may experience nausea, diarrhoea, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), peripheral neuropathy (nerves malfunction), fatigue, neuralgia, anaemia, leukopenia, constipation, vomiting, lymphopenia, rash, pyrexia, and anorexia. Most of these side effects of Bortemib 2 Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Bortemib 2 Injection for as long as your doctor has prescribed. Do not stop the Bortemib 2 Injection midway. Talk to your doctor before taking Bortemib 2 Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Avoid taking Bortemib 2 Injection if you are pregnant or breastfeeding because this Bortemib 2 Injection can cause harmful effects on the unborn baby. Both women and men using this Bortemib 2 Injection should use birth control to avoid pregnancy.

Uses of Bortemib 2 Injection

Multiple myeloma and Mantle cell lymphoma.

Medicinal Benefits Mweb

Medicinal Benefits

Bortemib 2 Injection contains the active substance bortezomib, also-called ‘proteasome inhibitor. Proteasomes play an important role in controlling cell function and growth. By interfering with their function, thereby it can kill cancer cells. Bortemib 2 Injection is used to treat multiple myeloma (a cancer of the bone marrow) and mantle cell lymphoma (a type of cancer affecting the lymph nodes) in 18 years or older patients. It can be used alone or together with other medicines.

Directions for Use

Bortemib 2 Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Side Effects of Bortemib 2 Injection

  • Nausea
  • Diarrhoea
  • Thrombocytopenia (low blood platelet count)
  • Neutropenia (too few neutrophils)
  • Peripheral neuropathy (nerves malfunction)
  • Fatigue (overtired)
  • Neuralgia (pain in the head or face)
  • Muscle pain, bone pain
  • Anaemia (low red blood cell Count)
  • Leukopenia (Low White Blood Cell Count)
  • High blood pressure
  • Constipation
  • Dehydration
  • Vomiting
  • Loss of appetite
  • Lymphopenia (Low lymphocytes Count)
  • Rash
  • Pyrexia (raised body temperature)
  • Anorexia (lack or loss of appetite for food)
  • Infections, including pneumonia, respiratory infections, bronchitis, fungal infections, coughing with phlegm, flu-like illness

Drug Warnings

To treat your condition effectually, continue taking Bortemib 2 Injection for as long as your doctor has prescribed. Do not stop the Bortemib 2 Injection midway. Talk to your doctor before taking Bortemib 2 Injection if you have allergies or if you are suffering from peripheral neuropathy (nerves malfunction), hypotension, cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumour lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. And also, inform your doctor if you have diabetes because this medicine can affect your blood glucose levels. Your doctor may require close monitoring of your blood glucose levels and change your diabetes medicine dose while being treated with Bortemib 2 Injection. Avoid taking Bortemib 2 Injection if you are pregnant because this Bortemib 2 Injection can cause harmful effects on the unborn baby. Both women and men using this Bortemib 2 Injection should use birth control to avoid pregnancy and for at least six months following treatment. Do not breastfeed during treatment with Bortemib 2 Injection and four months after your final dose of Bortemib 2 Injection.

Drug-Drug Interactions

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BortezomibFosphenytoin
Severe

Drug-Drug Interactions

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BortezomibFosphenytoin
Severe
How does the drug interact with Bortemib 2 Injection:
Coadministration of Bortemib 2 Injection and fosphenytoin may reduce the blood levels of Bortemib 2 Injection, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although using Bortemib 2 Injection and Fosphenytoin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, consult your doctor if your symptoms do not improve. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Bortemib 2 Injection:
Coadministration of adalimumab and Bortemib 2 Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortemib 2 Injection and Adalimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms of infection, such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Bortemib 2 Injection:
Taking Bortemib 2 Injection with carbamazepine may reduce the blood levels of Bortemib 2 Injection, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Bortemib 2 Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Bortemib 2 Injection:
Coadministration of phenytoin and Bortemib 2 Injection can lower the levels of Bortemib 2 Injection, which could decrease its effectiveness.

How to manage the interaction:
Although using Bortemib 2 Injection and Phenytoin together can result in an interaction, they can be taken together if advised by a doctor. However, consult a doctor if your condition worsens. Do not stop taking any medications without consulting a doctor.
BortezomibLomitapide
Severe
How does the drug interact with Bortemib 2 Injection:
Coadministration of lomitapide and Bortemib 2 Injection can increases the risk of liver problems.

How to manage the interaction:
Although using Bortemib 2 Injection and Lomitapide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, skin rash, itching, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Bortemib 2 Injection:
Taking tofacitinib and Bortemib 2 Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortemib 2 Injection and Tofacitinib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibGolimumab
Severe
How does the drug interact with Bortemib 2 Injection:
Coadministration of golimumab and Bortemib 2 Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortemib 2 Injection and Golimumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, discomfort, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibCertolizumab
Severe
How does the drug interact with Bortemib 2 Injection:
Coadministration of certolizumab and Bortemib 2 Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortemib 2 Injection and Certolizumab together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhoea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
BortezomibBCG vaccine
Severe
How does the drug interact with Bortemib 2 Injection:
Coadministration of the BCG vaccine and Bortemib 2 Injection can increase the risk of infection or decrease the vaccine response.

How to manage the interaction:
Taking Bortemib 2 Injection with the BCG vaccine together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
BortezomibVoclosporin
Severe
How does the drug interact with Bortemib 2 Injection:
Coadministration of voclosporin and Bortemib 2 Injection may increase the risk of infections.

How to manage the interaction:
Although using Bortemib 2 Injection and Voclosporin together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate

Drug-Food Interactions

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BORTEZOMIB-2MGCaffeine containing foods/drinks, Fiber rich foods
Moderate
Common Foods to Avoid:
Green Tea, Oranges

How to manage the interaction:
Vitamin C or vitamin-containing foods and green tea diminish the effectiveness of Bortemib 2 Injection Avoid or limit the consumption of Vitamin C or vitamin-containing foods and green tea.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • RITONAVIR
  • RIFAMPICIN
  • CARBAMAZEPINE
  • PHENYTOIN
  • PHENOBARBITAL

Habit Forming

No

Special Advise

  • Bortemib 2 Injection should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Bortemib 2 Injection.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, blood cell count in your blood.
  • Avoid unnecessary or prolonged exposure to sunlight and UV light (such as tanning booths) and wear protective clothing, sunglasses, and sunscreen. Bortemib 2 Injection may make your skin sensitive to sunlight.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep, and rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

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