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  3. CRIZALK 250MG CAPSULE

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
48 Hrs returnable
COD available

Online payment accepted

rxMedicinePrescription drug

Whats That

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Composition :

CRIZOTINIB-250MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - CRI0067

Author Details

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FAQs

Crizotinib is the active ingredient in CRIZALK 250MG CAPSULE. It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. CRIZALK 250MG CAPSULE is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.

In elderly patients, the risk of side effects is more if you take the CRIZALK 250MG CAPSULE. For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.

No, avoid smoking before starting the treatment and while taking CRIZALK 250MG CAPSULE as smoking might alter the effectiveness of CRIZALK 250MG CAPSULE.

Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.

CRIZALK 250MG CAPSULE may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Consuming alcohol while using CRIZALK 250MG CAPSULE is not recommended since it may produce side effects or make you more sensitive to the effects of alcohol.

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Pregnancy

Caution

CRIZALK 250MG CAPSULE is not typically recommended during the pregnancy. Please consult the healthcare professional if you have any concerns regarding this.

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Breast Feeding

Caution

CRIZALK 250MG CAPSULE is not typically recommended if you are a nursing woman. Please consult the healthcare professional if you have any concerns regarding this.

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Driving

Caution

Do not drive, or you should take special care when driving and using machines as patients taking CRIZALK 250MG CAPSULE may experience visual disturbances, dizziness, and tiredness.

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Liver

Caution

Caution should be taken while using CRIZALK 250MG CAPSULE in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be taken while using CRIZALK 250MG CAPSULE in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and efficacy have not been established.

About CRIZALK 250MG CAPSULE

CRIZALK 250MG CAPSULE belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on CRIZALK 250MG CAPSULE treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of CRIZALK 250MG CAPSULE in your body.

Uses of CRIZALK 250MG CAPSULE

Non-small cell lung cancer (NSCLC)

Medicinal Benefits Mweb

Medicinal Benefits

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Side Effects of CRIZALK 250MG CAPSULE

  • Visual disturbance
  • Stomach upset
  • Vomiting
  • Diarrhoea
  • Nausea
  • Constipation
  • Decreased appetite
  • Tiredness
  • Dizziness
  • Metallic taste
  • Abdomen pain

Drug Warnings

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take CRIZALK 250MG CAPSULE every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the CRIZALK 250MG CAPSULE.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizalk 250mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crizalk 250mg Capsule:
Taking Crizalk 250mg Capsule with Ceritinib may significantly increase the blood levels and effects of Crizalk 250mg Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizalk 250mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Crizalk 250mg Capsule:
Taking chlorpromazine and Crizalk 250mg Capsule together can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking chlorpromazine and Crizalk 250mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Crizalk 250mg Capsule:
Taking Gatifloxacin with Crizalk 250mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin with Crizalk 250mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Norfloxacin with Crizalk 250mg Capsule can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Crizalk 250mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crizalk 250mg Capsule:
Co-administration of Crizalk 250mg Capsule and Tetrabenazine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Crizalk 250mg Capsule and Tetrabenazine can lead to an interaction, but it can be taken if your doctor advises. However, contact your doctor immediately if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Crizalk 250mg Capsule:
Taking ondansetron with Crizalk 250mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking ondansetron along with Crizalk 250mg Capsule can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Crizalk 250mg Capsule:
Using Crizalk 250mg Capsule together with mirtazapine can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
There may be a possibility of interaction between Mirtazapine and Crizalk 250mg Capsule, but it can be taken if prescribed by a doctor. If you have any of these symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule together with ofloxacin may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Ofloxacin and Crizalk 250mg Capsule interact, they can be used if prescribed by a doctor. Consult a doctor if you have sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Crizalk 250mg Capsule:
Taking oxytocin with Crizalk 250mg Capsule can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Oxytocin with Crizalk 250mg Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience if you develop sudden dizziness, lightheadedness, fainting, shortness of breath contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • POSACONAZOLE
  • VORICONAZOLE
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • ERYTHROMYCIN
  • ATAZANAVIR
  • RITONAVIR
  • COBICISTAT
  • CARBAMAZEPINE
  • PHENOBARBITAL
  • RIFABUTIN
  • RIFAMPICIN
  • ST JOHN'S WORT

Habit Forming

No

Special Advise

  • If you have a fever or an infection, call your doctor. Your doctor may perform blood tests, and if the findings are abnormal, your doctor may opt to cut the dose of CRIZALK 250MG CAPSULE.
  • Inform your doctor as soon as possible if you notice any vision loss or changes in your vision, such as difficulties seeing out of one or both eyes.
  • During your therapy with CRIZALK 250MG CAPSULE, your doctor may recommend electrocardiograms to ensure that your heart is not causing any difficulties.

Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

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