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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Whats That

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Composition :

DEXAMETHASONE-4MG

Manufacturer/Marketer :

Searle India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

CORTICOSTEROIDS

Country of origin

INDIA

Manufacturer/Marketer address

RPG HOUSE, 463, Dr. Annie Besant Road, Worli,Mumbai - 400030
Other Info - DEX0217

FAQs

Dexadran Injection 2 ml contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

If you are about to be vaccinated, especially if it is a live vaccine, inform your doctor that you are taking Dexadran Injection 2 ml because taking Dexadran Injection 2 ml and getting immunised at the same time is not recommended.

Dexadran Injection 2 ml is not recommended to be used in fungal infections. If you have any concerns regarding this, please discuss them with your doctor.

Dexadran Injection 2 ml may increase the risk of Infections and infestations. Therefore, it is advised to stay away from people having chickenpox (herpes simplex), shingles (herpes zoster) or measles.

Dexadran Injection 2 ml is approved for the treatment of coronavirus disease 2019 (COVID-19) in adults and adolescents (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Caution is advised if you are taking anticoagulants while on Dexadran Injection 2 ml treatment. Checking your blood clotting time is recommended to lessen the risk of bleeding.

Disclaimer

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Alcohol

Caution

It is unknown whether alcohol interacts with Dexadran Injection 2 ml. Please consult your doctor.

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Pregnancy

Caution

If you are pregnant, inform your doctor. Your doctor will then decide if the Dexadran Injection 2 ml is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Breast Feeding

Caution

Inform your doctor if you are a nursing mother. The doctor will then decide if the injection is suitable for you. Your doctor may prescribe this medicine only if the benefits outweigh the risks.

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Driving

Caution

Dexadran Injection 2 ml may cause a reduction in mental awareness; thus, avoid operating machinery or driving.

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Liver

Caution

Inform your doctor before receiving the Dexadran Injection 2 ml if you have a history of or ongoing liver disease. Your doctor will adjust the dose of this medicine if required based on your condition.

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Kidney

Caution

Inform your doctor before receiving the Dexadran Injection 2 ml if you have a history of or ongoing kidney disease. Your doctor may carry out extra checks while you are taking this medicine.

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Children

Caution

Dexadran Injection 2 ml may affect the growth of children. Therefore, your doctor may check the growth of the child regularly while using the Dexadran Injection 2 ml.

About Dexadran Injection 2 ml

Dexadran Injection 2 ml belongs to a class of drugs called corticosteroids (hormones). When your body does not produce enough Dexamethasone, Dexadran Injection 2 ml is often utilized to replace it. It treats various medical conditions, including severe allergic conditions, collagen diseases, pulmonary disorders, blood disorders, rheumatic diseases, skin diseases, gastrointestinal disorders, oedema, eye disorders, neoplastic states and endocrine disorders. It is also used in preoperative and postoperative support. Furthermore, it is approved for the treatment of coronavirus disease 2019 (COVID-19) in adult and adolescent patients (aged 12 years and older with a body weight of at least 40 kg) who require supplemental oxygen therapy.

Dexadran Injection 2 ml contains dexamethasone, a steroid with both anti-inflammatory and immunosuppressant activity. Anti-inflammatory activity relieves the symptoms of inflammatory conditions such as redness, swelling, and tenderness caused by various medical conditions. On the other side, immunosuppressant activity helps to calm your immune system. As a result, it can aid in autoimmune diseases such as rheumatoid arthritis, in which your immune system erroneously destroys your own tissues.

Dexadran Injection 2 ml will be administered by a healthcare professional; do not self-administer. Some people may experience mood changes in personality, mental health problems, muscle weakness, increased appetite, irregular or absent menstrual periods, infections and infestations, impaired vision, difficulty falling asleep or staying asleep, heartburn, peptic ulcer, muscle weakness, nausea and injection site pain or redness as side effects of Dexadran Injection 2 ml. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Let your doctor know before prescribing Dexadran Injection 2 ml if you are allergic to any content of this medicine or sulphites. Inform your doctor if you are pregnant, planning for pregnancy or breastfeeding before receiving this medicine. Before obtaining the Dexadran Injection 2 ml, notify your doctor about your medical history and any other medications you are currently taking to rule out any potentially harmful effects.

Uses of Dexadran Injection 2 ml

Allergic or inflammatory conditions, Covid-19.

Medicinal Benefits Mweb

Medicinal Benefits

Dexadran Injection 2 ml is a steroid (corticosteroids) medication. Corticosteroids occur naturally in the body and contribute to overall health and well-being. Increasing your body's corticosteroid levels (such as dexamethasone) is an effective strategy for treating various disorders involving inflammation. Dexadran Injection 2 ml decreases inflammation, otherwise which might worsen your disease. You must take it daily to get the maximum benefits of Dexadran Injection 2 ml.

Directions for Use

Dexadran Injection 2 ml will be administered by a healthcare professional; do not self-administer.

Side Effects of Dexadran Injection 2 ml

  • Difficulty falling asleep or staying asleep
  • Mood changes in personality
  • Depression
  • Muscle weakness
  • Increased sweating
  • Increased appetite
  • Weight gain
  • Joint pain
  • Irregular or absent menstrual periods
  • Injection site pain or redness
  • Mental health problems
  • Infections and infestations
  • Abnormal growth of tissue
  • Abnormal increase in the number of white blood cells
  • Abnormal hair growth
  • Impaired vision
  • Vertigo (spinning sensation)
  • Headache
  • Cataracts or feeling increased pressure in the eye
  • Thickening of the heart muscle
  • High blood pressure
  • Blood clots in the veins
  • Nausea
  • Hiccups (sudden inspiration or intake of air)
  • Heartburn
  • Peptic ulcer
  • Muscle weakness
  • Loss of muscle mass
  • Osteoporosis (loss of bone density)

Drug Warnings

Before prescribing Dexadran Injection 2 ml, inform your doctor if you are allergic to any content of this medicine or other steroid medicines. You should disclose to your doctor if you have received any live virus vaccines. You should discuss with your doctor if you have fungal infections, amoebiasis, myasthenia gravis, peptic ulcer, osteoporosis, psychoses, eye infections, glaucoma, mental conditions, TB, bacteraemia (viable bacteria in the bloodstream), joint, liver, kidney, or heart conditions and septic arthritis resulting from gonorrhoea or tuberculosis. If you are pregnant, planning for pregnancy or breastfeeding, inform your doctor before receiving this medicine. Contact your doctor immediately if you notice mood changes or have depression and strange thoughts while Dexadran Injection 2 ml therapy.

Drug-Drug Interactions

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DexamethasoneRilpivirine
Critical

Drug-Drug Interactions

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DexamethasoneRilpivirine
Critical
How does the drug interact with Dexadran Injection 2 ml:
When Rilpivirine is taken with Dexadran Injection 2 ml, may significantly reduce the blood levels of Rilpivirine.

How to manage the interaction:
Co-administration of Rilpivirine and Dexadran Injection 2 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
When Dexadran Injection 2 ml is taken with Ranolazine, may significantly reduce the blood levels of Ranolazine.

How to manage the interaction:
Co-administration of Ranolazine and Dexadran Injection 2 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
When Regorafenib is taken with Dexadran Injection 2 ml, may significantly reduce the blood levels of Regorafenib.

How to manage the interaction:
Co-administration of Regorafenib and Dexadran Injection 2 ml can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
Co-administration of Desmopressin with Dexadran Injection 2 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Dexadran Injection 2 ml and Desmopressin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
Co-administration of Bempedoic acid with Dexadran Injection 2 ml can result in tendinitis (a condition in which the tissue connecting muscle to bone becomes inflamed) and tendon rupture (injuries to the soft tissues that connect muscles and joints).

How to manage the interaction:
Although there is an interaction, Bempedoic acid can be taken with Dexadran Injection 2 ml if prescribed by the doctor. However, if you experience pain, inflammation, or swelling of a tendon area such as the back of the ankle, biceps, shoulder, hand, or thumb, stop taking bempedoic acid and consult a doctor. Exercise and using the impacted area should both be avoided. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Taking Dexadran Injection 2 ml may reduce the blood levels of Axitinib, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, Dexadran Injection 2 ml can be taken with axitinib if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Co-administration of Amiodarone with Dexadran Injection 2 ml may reduce Amiodarone's effects.

How to manage the interaction:
Despite the possibility of an interaction between Amiodarone and Dexadran Injection 2 ml, you can take them if prescribed by a doctor. Inform your doctor if you have an abnormal heartbeat or a racing heart. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Taking Cladribine with Dexadran Injection 2 ml can increase the chances of serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Dexadran Injection 2 ml, you can take these medicines together if prescribed by a doctor. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Dexadran Injection 2 ml:
Co-administration of Dexadran Injection 2 ml with Moxifloxacin can cause tendinitis (inflammation of the thick fibrous cords that attach muscle to bone) and tendon rupture (injury to the soft tissue that connects muscle to bone).

How to manage the interaction:
Although there is a possible interaction, Dexadran Injection 2 ml can be taken with Moxifloxacin if prescribed by the doctor. Consult the doctor immediately if you experience pain, swelling, or inflammation of a tendon area such as the back of the ankle, shoulder, biceps, hand, or thumb. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dexadran Injection 2 ml:
Taking Dexadran Injection 2 ml may reduce the blood levels of Praziquantel, making the medication less effective.

How to manage the interaction:
Although there is a possible interaction, Dexadran Injection 2 ml can be taken with Praziquantel if prescribed by the doctor. Consult a doctor if your symptoms worsen or your condition changes. Do not discontinue the medication without a doctor's advice.

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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DEXAMETHASONE-4MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Dexadran Injection 2 ml with Caffeine may increase the side effects of Dexadran Injection 2 ml. Avoid consuming caffeine while taking Dexadran Injection 2 ml.

Drug-Diseases Interactions

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DEXAMETHASONE-4MGOther and unspecified infectious diseases
Severe
DEXAMETHASONE-4MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe

Drug-Diseases Interactions

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DEXAMETHASONE-4MGOther and unspecified infectious diseases
Severe
How does the disease interact with Dexadran Injection 2 ml:
Corticosteroids' immunosuppressive and anti-inflammatory properties, especially when used in larger doses, have the potential to reduce host resistance to pathogens, impair the capacity to localise infections, and disguise infection-related symptoms. Perhaps secondary infections are more prone to occur. In general, corticosteroids should not be administered to patients with active infections, particularly systemic fungal infections, unless absolutely essential for medical reasons and after effective antimicrobial medication or another suitable course of treatment has been started.

How to manage the interaction:
Corticosteroids, particularly in higher dosages, may decrease host resistance to infectious agents, decrease the ability to localize infections, and mask the symptoms of infection.
DEXAMETHASONE-4MGDisorders related to short gestation and low birth weight, not elsewhere classified
Severe
How does the disease interact with Dexadran Injection 2 ml:
Manufacturers of the drugs believe that using some parenteral formulations of Dexadran Injection 2 ml, hydrocortisone, methylprednisolone, prednisolone, and triamcinolone in neonates, especially preterm newborns and infants with low birth weight, is contraindicated.

How to manage the interaction:
The use of certain parenteral formulations of Dexadran Injection 2 ml is contraindicated in neonates, particularly premature infants and infants of low birth weight.
DEXAMETHASONE-4MGFibrosis and cirrhosis of liver
Moderate
How does the disease interact with Dexadran Injection 2 ml:
Due to cirrhosis patients' lower metabolism, corticosteroids may have stronger effects on them. Patients with cirrhosis need to have their cortisol levels constantly checked. For certain people, dosage modifications may be necessary.

How to manage the interaction:
Patients with cirrhosis should be monitored more closely for excessive cortisol effects.
DEXAMETHASONE-4MGOther mental disorders due to brain damage and dysfunction and to physical disease
Moderate
How does the disease interact with Dexadran Injection 2 ml:
Psychotic and emotional instability symptoms may be made worse by corticosteroids. During corticosteroid medication, patients with these disorders should be monitored for any worsening or intensification of their symptoms.

How to manage the interaction:
Patients with psychosis and emotional instability should be monitored for increased or worsened symptoms during corticosteroid therapy.
DEXAMETHASONE-4MGUnspecified diabetes mellitus
Moderate
How does the disease interact with Dexadran Injection 2 ml:
By opposing the effect of insulin and inhibiting its production, corticosteroids can increase blood sugar levels. This inhibits peripheral glucose absorption and increases gluconeogenesis. Patients with diabetes mellitus, glucose intolerance, or a tendency for hyperglycemia should receive corticosteroid therapy with caution. During corticosteroid medication, patients with diabetes mellitus should be evaluated more carefully, and their anti-diabetic regimen should be changed correspondingly.

How to manage the interaction:
Patients with diabetes mellitus should be monitored more closely during corticosteroid therapy, and their antidiabetic regimen adjusted accordingly.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • PHENYTOIN
  • PHENOBARBITAL
  • PRIMIDONE
  • RIFAMPICIN
  • RIFABUTIN
  • AMINOGLUTETHIMIDE
  • WARFARIN
  • RITONAVIR
  • DARUNAVIR
  • CARBAMAZEPINE

Habit Forming

No

Special Advise

  • Dexadran Injection 2 ml may affect various laboratory tests. Therefore, inform your doctor/lab technician, that you are on treatment with Dexadran Injection 2 ml if you are undergoing any tests.

Diet & Lifestyle Advise

Diet & Lifestyle for Allergic or inflammatory conditions:

  • Consume antioxidant-rich food. Blueberries, tomatoes, cherries, squash, and bell peppers are highly antioxidants.
  • Consuming probiotic-rich foods aids in the development of the immune system's resistance to allergies.
  • Consume foods rich in quercetin (a flavonoid), such as apples, cherries, spinach, broccoli, and blueberries.
  • Include seasonal fruits, vegetables, whole grains, healthy fats, and fish in your daily diet.
  • Limit your intake of foods that may cause allergies, such as dairy products, soy, eggs, and nuts.
  • Limit the consumption of foods high in sugar that may aggravate inflammation.
  • Reducing stress and having a regular sleep schedule might be beneficial.
  • Avoid processed meats, refined carbohydrates, sugar, trans fats, and alcohol, as they may aggravate inflammation.

 

Diet & Lifestyle for Covid-19:

  • Remember always to wear a mask when you're around other people. Wearing a mask aids in the prevention of illness spread.
  • Take care of your mental health. Fear and anxiety can hamper the immune system as well. Therapy, yoga, and meditation effectively allow the mind a state of peace.
  • Keep a social distance and avoid social gatherings.
  • Please do not touch your eyes, nose or mouth if your hands are not clean.
  • Hands should be washed with soap and water or an alcohol-based sanitiser on a regular basis.
  • All surfaces should be cleaned and disinfected on a regular basis.
  • Gargling with salt water and inhaling steam would be beneficial.
  • Never exchange personal objects that have been contaminated with bodily fluids or blood, such as razor blades or toothbrushes.
  • Never share used needles and other injections or medical devices, as they may spread viruses.
  • Consume a well-balanced diet. Consume vitamin and nutrient-rich foods like dark green, yellow, orange, and red vegetables and fruits to enhance your immune system. Choose lean protein and whole carbohydrates over-processed foods.
  • Consume no raw meat or eggs. Consume boiled and cooked meat, poultry, or seafood.
  • If you have nausea or vomiting, eat bland, low-fat foods and avoid spicy or greasy foods.
  • Spending time with family or doing whatever makes you happy might help you minimise emotional and physical stress.

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