Espra XN 500 Tablet belongs to a group of medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) or painkillers used to reduce and relieve pain. Pain is a highly unpleasant physical sensation caused by illness or injury.

Espra XN 500 Tablet combines Naproxen (painkiller) and esomeprazole (antacid). Naproxen is an anti-inflammatory drug that works by blocking the action of the body's cyclo-oxygenase (COX) enzyme to produce certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site, decreasing joint stiffness. Naproxen has been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. Hence, combined with esomeprazole (proton pump inhibitors), it reduces the amount of acid made by the stomach, thus preventing damage to the stomach. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Take Espra XN 500 Tablet as prescribed by your doctor. You are advised to take Espra XN 500 Tablet for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience indigestion, stomach pain, constipation, dizziness, nausea, and diarrhoea. Most of these side effects of Espra XN 500 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Before taking this medicine, inform your doctor if you have any known allergy to Naproxen, esomeprazole, other NSAIDs, or other medications. If pregnant or breastfeeding, please inform your doctor before taking the Espra XN 500 Tablet . Also, inform the doctor if you have a history of heart rhythm problems or ulcers due to painkillers. Patients with age above 65 years, with pre-existing cardiac diseases such as heart failure, hypertension or stroke, gastrointestinal bleeding (due to pain killers), gastric ulcers, respiratory diseases such as asthma, liver diseases, kidney diseases, or bleeding disorders should use Espra XN 500 Tablet only when prescribed by a doctor. Keep your doctor informed about your health condition and all the medicines you take before taking Espra XN 500 Tablet to rule out any side effects.

Espra XN 500 Tablet contains Naproxen and esomeprazole (antacid). Naproxen is an anti-inflammatory (reduces inflammation) and an analgesic (relieves pain) agent that works by blocking the action of the cyclo-oxygenase (COX) enzyme in the body that is involved in the production of certain chemical substances (prostaglandins) that cause pain and swelling. This helps reduce mild to moderate pain and inflammation at the injured or damaged site, decreasing joint stiffness. It also treats fibrositis (muscle pain and stiffness), tenosynovitis (swelling of tendons), low back pain, strains, and sprains. NSAIDs such as Naproxen have been reported to cause gastric discomfort, acidity, and risk of stomach ulcers. To reduce gastric discomfort and stomach ulceration risk, it is combined with esomeprazole (a proton pump inhibitor that inhibits gastric acid secretion) to reduce stomach acid production during long-term treatment for people with pre-existing stomach ulcers or for people having a history of developing stomach ulcers while using NSAIDs. Thus, the combination helps alleviate pain with minimal gastric irritation caused due to Naproxen alone.

Do not take Espra XN 500 Tablet if you are allergic to Espra XN 500 Tablet . Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin), such as naproxen, may increase the risk of heart attack, stroke, and stomach ulcers. The risk of developing ulcers is higher if you have a history of ulcers, have bleeding disorders, are older, are alcoholics, or have multiple diseases. Elderly patients are at greater risk for gastrointestinal bleeding problems, so the doctor can limit their dose. It should not be used by a patient who has undergone recent heart bypass surgery or going to have it. Espra XN 500 Tablet is not recommended for pregnant women, especially in the third trimester, as it may cause harm to the baby. Therefore, pregnant or breastfeeding women are advised to consult a doctor before taking Espra XN 500 Tablet . Espra XN 500 Tablet should not be given to children unless prescribed by a doctor. Do not take any other NSAIDs for pain relief along with Espra XN 500 Tablet unless prescribed. Prolonged proton pump inhibitors like esomeprazole may cause brittle bones, so your doctor may recommend taking Vitamin D and calcium while using Espra XN 500 Tablet . Do not consume alcohol with Espra XN 500 Tablet as it may increase the risk of stomach bleeding or ulcer.

• If you are elderly, a smoker who had a stroke previously, or have high blood pressure, diabetes or high cholesterol, please inform your doctor, as these conditions may increase the risk of heart problems.
• Your doctor may monitor liver and kidney function if you take Espra XN 500 Tablet for the long-term.
• Individuals at risk for osteoporosis-related fractures should receive adequate calcium and vitamin D intake.
• Esomeprazole in Espra XN 500 Tablet  may interfere with specific laboratory tests (including urine test for tetrahydrocannabinol-THC, a blood test to find certain tumours), possibly causing false test results. Make sure laboratory personnel and all your doctors know you are using Espra XN 500 Tablet .
• Regular monitoring of vitamin B-12, rarely, esomeprazole in Espra XN 500 Tablet has chased vitamin B-12 deficiency. The risk increases if they take Espra XN 500 Tablet every day for a long time.