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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - ETI0119

FAQs

Etibo 250 mg Tablet contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.

Inform your doctor whether you have received any other breast cancer treatment. Etibo 250 mg Tablet may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Etibo 250 mg Tablet .

Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Etibo 250 mg Tablet . Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

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Pregnancy

Unsafe

Etibo 250 mg Tablet is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Etibo 250 mg Tablet . Use reliable methods of birth control while on treatment with Etibo 250 mg Tablet .

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Etibo 250 mg Tablet as it can cause serious side effects to the newborn baby.

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Driving

Consult your doctor

It is unknown whether Etibo 250 mg Tablet will affect your mental ability to drive or operate machines. Hence, consult your doctor for information regarding this.

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Liver

Caution

Inform your doctor if you have any pre-existing liver disease. Your doctor may adjust the dose of the medicine based on the condition. Etibo 250 mg Tablet is known to cause hepatotoxicity in some patients. If you notice any reactions such as itching, yellowing of the skin or eyes, dark urine, abdominal pain, unusual bleeding, or pale or dark stools, discontinue the treatment and inform your doctor immediately.

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Kidney

Caution

Limited data are available on the effect of Etibo 250 mg Tablet in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Etibo 250 mg Tablet is not recommended for use in children as the safety and efficacy are not established.

About Etibo 250 mg Tablet

Etibo 250 mg Tablet is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Etibo 250 mg Tablet is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

Etibo 250 mg Tablet contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Etibo 250 mg Tablet may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Etibo 250 mg Tablet should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

Etibo 250 mg Tablet should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking Etibo 250 mg Tablet . Etibo 250 mg Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

Uses of Etibo 250 mg Tablet

Breast Cancer.

Medicinal Benefits Mweb

Medicinal Benefits

Etibo 250 mg Tablet contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Directions for Use

Take Etibo 250 mg Tablet as prescribed by your doctor. It should be taken one hour before or at least one hour after. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Side Effects of Etibo 250 mg Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Dry skin
  • Hair loss
  • Tiredness
  • Weakness
  • Headache
  • Fatigue

Drug Warnings

Etibo 250 mg Tablet should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Etibo 250 mg Tablet may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Etibo 250 mg Tablet is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Etibo 250 mg Tablet should be given to children only if prescribed by the paediatrician. Etibo 250 mg Tablet is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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LapatinibItraconazole
Severe
LapatinibColchicine
Severe

Drug-Drug Interactions

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LapatinibItraconazole
Severe
How does the drug interact with Etibo 250 mg Tablet:
Using Etibo 250 mg Tablet together with itraconazole may significantly increase the blood levels of Etibo 250 mg Tablet.

How to manage the interaction:
Etibo 250 mg Tablet and itraconazole may interact, but if a doctor prescribes them, you can still use them. If you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and yellowing of the skin or eyes, diarrhoea, dizziness, lightheadedness, fainting, shortness of breath, or rapid or pounding heartbeats, seek medical attention. Never discontinue taking a medication without consulting a doctor.
LapatinibColchicine
Severe
How does the drug interact with Etibo 250 mg Tablet:
Coadministration of colchicine with Etibo 250 mg Tablet results in increased colchicine levels in the blood, increasing the risk of serious side effects

How to manage the interaction:
Although taking Colchicine and Etibo 250 mg Tablet together may possibly result in an interaction, they can be taken together if your doctor prescribes it. However, if you experience abdominal pain, numbness or tingling in your hands and legs, muscle pain, or weakness, contact your doctor immediately. Do not discontinue any medication without consulting your doctor.
LapatinibClozapine
Severe
How does the drug interact with Etibo 250 mg Tablet:
When Clozapine is taken with Etibo 250 mg Tablet, can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
Taking Clozapine with Etibo 250 mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. You may also experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, sudden dizziness, feeling lightheaded, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
LapatinibMoxifloxacin
Severe
How does the drug interact with Etibo 250 mg Tablet:
Using Moxifloxacin together with Etibo 250 mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Moxifloxacin and Etibo 250 mg Tablet, you can take these medicines together if prescribed by a doctor. If you experience irregular heart rhythm, dizziness, difficulty breathing, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LapatinibSotalol
Severe
How does the drug interact with Etibo 250 mg Tablet:
Taking Sotalol and Etibo 250 mg Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Etibo 250 mg Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
LapatinibDisopyramide
Severe
How does the drug interact with Etibo 250 mg Tablet:
The combined use of Etibo 250 mg Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Etibo 250 mg Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibGatifloxacin
Severe
How does the drug interact with Etibo 250 mg Tablet:
Taking Gatifloxacin and Etibo 250 mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Etibo 250 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LapatinibLoperamide
Severe
How does the drug interact with Etibo 250 mg Tablet:
When taken in combination Etibo 250 mg Tablet may significantly raise the loperamide levels in the blood. This can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Although taking loperamide with Etibo 250 mg Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
LapatinibMorphine
Severe
How does the drug interact with Etibo 250 mg Tablet:
Coadministration of Morphine with Etibo 250 mg Tablet may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Etibo 250 mg Tablet with Morphine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, drowsiness, difficulty concentrating, impairment in judgment, reaction speed and motor coordination, headaches, irritation, confusion, oedema, fatigue, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LapatinibDigoxin
Severe
How does the drug interact with Etibo 250 mg Tablet:
Co-administration of Digoxin and Etibo 250 mg Tablet may increase the blood levels and effects of Digoxin.

How to manage the interaction:
If you are supposed to take Digoxin and Etibo 250 mg Tablet together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive digoxin levels. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • KETOCONAZOLE
  • RITONAVIR
  • VERAMAPIL
  • DILTIAZEM
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • ST JOHN'S WORT
  • INDINAVIR
  • EFAVIRENZ
  • ITRACONAZOLE

Habit Forming

No

Special Advise

  • Avoid intercourse while on treatment with Etibo 250 mg Tablet .
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • This medicine should be taken only once daily as prescribed by the doctor. Do not divide the dose of the medicine.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Etibo 250 mg Tablet Substitute

Substitutes safety advice
  • Tykerb 250 mg Tablet 30's

    by AYUR

    300.30per tablet
  • Herduo Tablet 30's

    by Others

    164.00per tablet
  • Combinib 250Mg Tablet 30'S

    by AYUR

    224.90per tablet
  • Abnib 250 mg Tablet 30's

    by Others

    252.67per tablet
  • Libset Tablet 30's

    by AYUR

    163.86per tablet
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