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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Allieva Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

14/16/1, Site 4, Sahibabad Industrial Area Site 4, Sahibabad, Ghaziabad, Uttar Pradesh 201010
Other Info - LAP0068

FAQs

Lapalieva 250 mg Tablet 30's contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.

Inform your doctor whether you have received any other breast cancer treatment. Lapalieva 250 mg Tablet 30's may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Lapalieva 250 mg Tablet 30's.

Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Lapalieva 250 mg Tablet 30's. Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Alcohol intake might increase the risk of worsening your condition. Hence, avoid alcohol consumption till your condition improves.

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Pregnancy

Unsafe

Lapalieva 250 mg Tablet 30's is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Lapalieva 250 mg Tablet 30's. Use reliable methods of birth control while on treatment with Lapalieva 250 mg Tablet 30's.

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Lapalieva 250 mg Tablet 30's as it can cause serious side effects to the newborn baby.

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Driving

Consult your doctor

It is unknown whether Lapalieva 250 mg Tablet 30's will affect your mental ability to drive or operate machines. Hence, consult your doctor for information regarding this.

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Liver

Caution

Inform your doctor if you have any pre-existing liver disease. Your doctor may adjust the dose of the medicine based on the condition. Lapalieva 250 mg Tablet 30's is known to cause hepatotoxicity in some patients. If you notice any reactions such as itching, yellowing of the skin or eyes, dark urine, abdominal pain, unusual bleeding, or pale or dark stools, discontinue the treatment and inform your doctor immediately.

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Kidney

Caution

Limited data are available on the effect of Lapalieva 250 mg Tablet 30's in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Lapalieva 250 mg Tablet 30's is not recommended for use in children as the safety and efficacy are not established.

About Lapalieva 250 mg Tablet 30's

Lapalieva 250 mg Tablet 30's is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Lapalieva 250 mg Tablet 30's is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

Lapalieva 250 mg Tablet 30's contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Lapalieva 250 mg Tablet 30's may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Lapalieva 250 mg Tablet 30's should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

Lapalieva 250 mg Tablet 30's should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking Lapalieva 250 mg Tablet 30's. Lapalieva 250 mg Tablet 30's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

Uses of Lapalieva 250 mg Tablet 30's

Breast Cancer.

Medicinal Benefits Mweb

Medicinal Benefits

Lapalieva 250 mg Tablet 30's contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Directions for Use

Take Lapalieva 250 mg Tablet 30's as prescribed by your doctor. It should be taken one hour before or at least one hour after. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Side Effects of Lapalieva 250 mg Tablet 30's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Dry skin
  • Hair loss
  • Tiredness
  • Weakness
  • Headache
  • Fatigue

Drug Warnings

Lapalieva 250 mg Tablet 30's should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Lapalieva 250 mg Tablet 30's may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Lapalieva 250 mg Tablet 30's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Lapalieva 250 mg Tablet 30's should be given to children only if prescribed by the paediatrician. Lapalieva 250 mg Tablet 30's is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Lapalieva 250 mg Tablet:
Taking Sotalol and Lapalieva 250 mg Tablet can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Lapalieva 250 mg Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Taking Gatifloxacin and Lapalieva 250 mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Lapalieva 250 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Combining Lapalieva 250 mg Tablet with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Co-administration of Escitalopram with Lapalieva 250 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience dizziness, fainting, abnormal heart rhythm, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Coadministration of Lapalieva 250 mg Tablet and ketoconazole may greatly increase Lapalieva 250 mg Tablet blood levels. This can increase the risk for side effects (diarrhea, liver damage, and heart problems like decreased heartbeat and irregular heartbeat).

How to manage the interaction:
Although taking Ketoconazole and Lapalieva 250 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, sudden dizziness, lightheadedness, fainting; shortness of breath, or rapid or pounding heartbeats. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
The combined use of Lapalieva 250 mg Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Lapalieva 250 mg Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Taking Lapalieva 250 mg Tablet with ceritinib may significantly increase the blood levels of Lapalieva 250 mg Tablet. This can make you more likely to develop side effects such as diarrhea and liver problems.

How to manage the interaction:
Co-administration of Ceritinib with Lapalieva 250 mg Tablet can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Coadministration of colchicine with Lapalieva 250 mg Tablet results in increased colchicine levels in the blood, increasing the risk of serious side effects

How to manage the interaction:
Although taking Colchicine and Lapalieva 250 mg Tablet together may possibly result in an interaction, they can be taken together if your doctor prescribes it. However, if you experience abdominal pain, numbness or tingling in your hands and legs, muscle pain, or weakness, contact your doctor immediately. Do not discontinue any medication without consulting your doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
When Clozapine is taken with Lapalieva 250 mg Tablet, can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
Taking Clozapine with Lapalieva 250 mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away. You may also experience fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, sudden dizziness, feeling lightheaded, fainting, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Taking Lapalieva 250 mg Tablet with posaconazole can increase the levels of Lapalieva 250 mg Tablet in the blood, which can lead to an increased risk of side effects such as diarrhea, liver problems, and heart problems.

How to manage the interaction:
Although using Posaconazole and Lapalieva 250 mg Tablet together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Lapalieva 250 mg Tablet:
Taking clarithromycin with Lapalieva 250 mg Tablet may increase the blood levels of Lapalieva 250 mg Tablet. This might make you more likely to develop side effects such as diarrhea, liver damage, and heart problems.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Lapalieva 250 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with Lapalieva 250 mg Tablet. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • KETOCONAZOLE
  • RITONAVIR
  • VERAMAPIL
  • DILTIAZEM
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • ST JOHN'S WORT
  • INDINAVIR
  • EFAVIRENZ
  • ITRACONAZOLE

Habit Forming

No

Special Advise

  • Avoid intercourse while on treatment with Lapalieva 250 mg Tablet 30's.
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • This medicine should be taken only once daily as prescribed by the doctor. Do not divide the dose of the medicine.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Lapalieva 250 mg Tablet 30's Substitute

Always consult your doctor before taking any new medications and supplements

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