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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Composition :

FOSFOMYCIN-4GM

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Return Policy :

Not Returnable

Therapeutic Class

Other Info - FON0016

Author Details

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About Fonyl 4gm Injection

Uses of Fonyl 4gm Injection

Medicinal Benefits Mweb

Key Benefits

Directions for Use

Side Effects of Fonyl 4gm Injection

Drug Warnings

Drug-Drug Interactions

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FosfomycinCholera vaccines
Severe

Drug-Drug Interactions

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FosfomycinCholera vaccines
Severe
How does the drug interact with Fonyl 4gm Injection:
Co-administration of the Cholera vaccine with Fonyl 4gm Injection may reduce the activity of the Cholera vaccine.

How to manage the interaction:
If you are currently being treated with Fonyl 4gm Injection or have been treated within the last 14 days, inform your doctor before receiving cholera vaccine, live. Avoid receiving cholera vaccine, live until at least 14 days after you complete your antibiotic therapy to ensure adequate vaccine response.
How does the drug interact with Fonyl 4gm Injection:
Fonyl 4gm Injection may reduce the effect of balsalazide when taken orally.

How to manage the interaction:
If you are supposed to take Fonyl 4gm Injection and Balsalazide together, your doctor may adjust the dose or monitor you more frequently to use both medications safely.
FosfomycinBCG vaccine
Severe
How does the drug interact with Fonyl 4gm Injection:
When BCG vaccine is used with Fonyl 4gm Injection, its effectiveness may be reduced.

How to manage the interaction:
Taking Fonyl 4gm Injection with the BCG vaccine can lead to an interaction, please consult a doctor before taking it.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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FOSFOMYCIN-4GMVascular disorders of intestine
Severe
FOSFOMYCIN-4GMCare involving dialysis
Moderate

Drug-Diseases Interactions

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FOSFOMYCIN-4GMVascular disorders of intestine
Severe
How does the disease interact with Fonyl 4gm Injection:
Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy. All individuals who get diarrhoea after taking an antibiotic must be evaluated for CDAD. Careful medical history is required because CDAD has been known to happen more than two months following antibiotic use. Broad-spectrum antibiotics and other medications with potent antibacterial properties should be used in therapy.

How to manage the interaction:
Fonyl 4gm Injection should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the large intestine), pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus).
FOSFOMYCIN-4GMCare involving dialysis
Moderate
How does the disease interact with Fonyl 4gm Injection:
Hemodialysis removes Fonyl 4gm Injection, therefore it needs to be given after treatments.

How to manage the interaction:
As Fonyl 4gm Injection is removed by hemodialysis, it should be administered after dialysis sessions.
FOSFOMYCIN-4GMUnspecified kidney failure
Mild
How does the disease interact with Fonyl 4gm Injection:
Fonyl 4gm Injection is excreted intact in the faeces (18%) and by the kidneys (38%) of healthy adults. In patients with impaired renal function, the excretion of Fonyl 4gm Injection is greatly reduced, and the half-life is prolonged. In patients with renal insufficiency, side symptoms (such as diarrhoea, headache, nausea, and vaginitis) may last longer.

How to manage the interaction:
Fonyl 4gm Injection should be used with caution in patients with kidney failure. However, if the side effects, such as headache, diarrhoea, nausea, and vaginitis (inflammation or infection of the vagina) worsen, please consult your doctor.

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