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Alcohol
Caution
The interaction of alcohol with Fosfotas 4gm Injection is unknown. Hence, avoid or limit alcohol consumption while on treatment with Fosfotas 4gm Injection.
Pregnancy
Safe if prescribed
Fosfotas 4gm Injection is considered safe to be used in pregnancy. However, if you are pregnant, inform your doctor before receiving Fosfotas 4gm Injection. Your doctor prescribes this medicine if the benefits outweigh the risks.
Breast Feeding
Safe if prescribed
Small amounts of Fosfotas 4gm Injection are excreted in human milk. Therefore, it is given to breastfeeding mothers only if the doctor thinks the benefits are greater than the risks.
Driving
Caution
Fosfotas 4gm Injection may cause weakness or confusion in some people. Therefore, avoid driving if you notice any of these symptoms after taking Fosfotas 4gm Injection.
Liver
Caution
Please consult a doctor if you have a history of liver diseases/conditions.
Kidney
Caution
Take Fosfotas 4gm Injection with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.
Children
Caution
Fosfotas 4gm Injection may be used with caution in children if prescribed by a doctor, and the dose depends on the child’s age and weight.
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Drug-Drug Interactions
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Fosfotas 4 gm Injection may reduce the effect of balsalazide when taken orally.
How to manage the interaction:
If you are supposed to take Fosfotas 4 gm Injection and Balsalazide together, your doctor may adjust the dose or monitor you more frequently to use both medications safely.
Co-administration of the Cholera vaccine with Fosfotas 4 gm Injection may reduce the activity of the Cholera vaccine.
How to manage the interaction:
If you are currently being treated with Fosfotas 4 gm Injection or have been treated within the last 14 days, inform your doctor before receiving cholera vaccine, live. Avoid receiving cholera vaccine, live until at least 14 days after you complete your antibiotic therapy to ensure adequate vaccine response.
When BCG vaccine is used with Fosfotas 4 gm Injection, its effectiveness may be reduced.
How to manage the interaction:
Taking Fosfotas 4 gm Injection with the BCG vaccine can lead to an interaction, please consult a doctor before taking it.
Drug-Food Interactions
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Drug-Diseases Interactions
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Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C difficile, whose toxins A and B contribute to the emergence of CDAD. When C difficile strains produce hypertoxins, morbidity and death rise; severe infections may not respond to antibiotic therapy and may necessitate colectomy. All individuals who get diarrhoea after taking an antibiotic must be evaluated for CDAD. Careful medical history is required because CDAD has been known to happen more than two months following antibiotic use. Broad-spectrum antibiotics and other medications with potent antibacterial properties should be used in therapy.
How to manage the interaction:
Fosfotas 4 gm Injection should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation of the large intestine), pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps, and sometimes associated with the passage of blood and mucus).
Hemodialysis removes Fosfotas 4 gm Injection, therefore it needs to be given after treatments.
How to manage the interaction:
As Fosfotas 4 gm Injection is removed by hemodialysis, it should be administered after dialysis sessions.
Fosfotas 4 gm Injection is excreted intact in the faeces (18%) and by the kidneys (38%) of healthy adults. In patients with impaired renal function, the excretion of Fosfotas 4 gm Injection is greatly reduced, and the half-life is prolonged. In patients with renal insufficiency, side symptoms (such as diarrhoea, headache, nausea, and vaginitis) may last longer.
How to manage the interaction:
Fosfotas 4 gm Injection should be used with caution in patients with kidney failure. However, if the side effects, such as headache, diarrhoea, nausea, and vaginitis (inflammation or infection of the vagina) worsen, please consult your doctor.
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