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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

VALPROIC ACID-250MG

Manufacturer/Marketer :

Matias Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Therapeutic Class

ANTICONVULSANT

Country of origin

India

Manufacturer/Marketer address

101-104 Gcp Business Centre Opp. Memnagar Fire Station Vijay Cross Road Memnagar Ahmedabad-380014 India
Other Info - MAN0591

Author Details

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FAQs

Manigrain Er 250 Tablet 10's decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Manigrain Er 250 Tablet 10's helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Manigrain Er 250 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Manigrain Er 250 Tablet 10's. Avoid getting pregnant while taking Manigrain Er 250 Tablet 10's as it could lead to serious birth defects. Do not stop taking Manigrain Er 250 Tablet 10's and consult your doctor immediately if you become pregnant.

Manigrain Er 250 Tablet 10's may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Caution

Do not consume alcohol while taking Manigrain Er 250 Tablet 10's as alcohol can worsen the side effects of the Manigrain Er 250 Tablet 10's, including sleepiness and dizziness.

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Pregnancy

Unsafe

Manigrain Er 250 Tablet 10's is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Manigrain Er 250 Tablet 10's.

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Breast Feeding

Caution

Manigrain Er 250 Tablet 10's passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Manigrain Er 250 Tablet 10's. Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Caution

Manigrain Er 250 Tablet 10's may cause dizziness, drowsiness or tiredness in some people. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Manigrain Er 250 Tablet 10's.

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Liver

Caution

Inform your doctor before receiving the Manigrain Er 250 Tablet 10's if you have a history of liver diseases/conditions. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Manigrain Er 250 Tablet 10's.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Consult your doctor

Use is not recommended for children less than ten years. Your doctor will decide the dose based on your child's condition if more than ten years.

About Manigrain Er 250 Tablet 10's

Manigrain Er 250 Tablet 10's belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. In addition, Manigrain Er 250 Tablet 10's also treats manic episodes associated with bipolar disorder. Besides this, it can also prevent migraine symptoms (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

Manigrain Er 250 Tablet 10's contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

Manigrain Er 250 Tablet 10's should be taken as prescribed by the doctor. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects are temporary and will go away on their own. However, if you suffer these adverse effects on a regular basis, you should consult your doctor.

Inform your doctor if you are allergic to any components present in Manigrain Er 250 Tablet 10's. If you are pregnant, do not take Manigrain Er 250 Tablet 10's because it may cause serious congenital defects. Use effective contraception if you are of childbearing age while taking Manigrain Er 250 Tablet 10's. If you are breastfeeding, inform your doctor before taking Manigrain Er 250 Tablet 10's. As Manigrain Er 250 Tablet 10's causes sleepiness and dizziness, do not drive or operate machinery. Avoid drinking alcohol with Manigrain Er 250 Tablet 10's as it may cause dizziness and tiredness. To rule out any negative effects, keep your doctor updated about your health condition and medications.

Uses of Manigrain Er 250 Tablet 10's

Epilepsy (fits), Bipolar disorder, Migraine

Medicinal Benefits Mweb

Medicinal Benefits

Manigrain Er 250 Tablet 10's contains Valproic acid, an anticonvulsant (or anti-epileptic) medicine that reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. Manigrain Er 250 Tablet 10's raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. Manigrain Er 250 Tablet 10's limits the transmission of nerve pain, thereby preventing migraine headaches.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Side Effects of Manigrain Er 250 Tablet 10's

  • Stomach pain
  • Feeling or being sick
  • Diarrhoea
  • Dry or sore mouth or swollen gums
  • Shakes (tremors) in a part of your body
  • Unusual eye movements
  • Feeling tired or sleepy
  • Headache
  • Weight gain
  • Thinning hair, or changes to the colour or texture of your hair
  • Irregular or delayed periods

Drug Warnings

Before taking the Manigrain Er 250 Tablet 10's, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding. You should not become pregnant while you are receiving Manigrain Er 250 Tablet 10's. Consult your doctor immediately if you become pregnant while receiving a Manigrain Er 250 Tablet 10's. Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving Manigrain Er 250 Tablet 10's.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexEsketamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Glycerol phenylbutyrate and Manigrain Er 250 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Manigrain Er 250 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Esketamine and Manigrain Er 250 Tablet can increase the side effects of esketamine.

How to manage the interaction:
Although taking Manigrain Er 250 Tablet and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexBuprenorphine
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of buprenorphine with Manigrain Er 250 Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Manigrain Er 250 Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Sodium phenylbutyrate and Manigrain Er 250 Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexVorinostat
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Manigrain Er 250 Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Manigrain Er 250 Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexLamotrigine
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Coadministration of Manigrain Er 250 Tablet and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Manigrain Er 250 Tablet and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexSodium oxybate
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Sodium oxybate and Manigrain Er 250 Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Manigrain Er 250 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexLomitapide
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.
DivalproexMipomersen
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Manigrain Er 250 Tablet:
Co-administration of Manigrain Er 250 Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Manigrain Er 250 Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CARBAMAZEPINE
  • WARFARIN
  • ASPIRIN
  • CIMETIDINE
  • RITONAVIR
  • ERYTHROMYCIN
  • VENLAFAXINE
  • QUETIAPINE
  • CHOLESTYRAMINE
  • MEFLOQUINE
  • CHLOROQUINE

Habit Forming

No

Special Advise

  • Blood and urine tests may be affected by the Manigrain Er 250 Tablet 10's. Inform the person conducting the exams that you will be taking Manigrain Er 250 Tablet 10's.
  • If you are of childbearing age, utilise effective contraception continuously during your treatment with Manigrain Er 250 Tablet 10's.
  • Contact your doctor immediately if you become pregnant while taking Manigrain Er 250 Tablet 10's.

Diet & Lifestyle Advise

  • Adolescents and adults are advised to follow the Atkins diet (high fat, low carbohydrate).
  • Exercising on a regular basis aids with weight maintenance and general health.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can help reduce stress, reduce pain sensitivity, and increase coping abilities.
  • Have a seizure response plan in place, and make sure everyone around you knows what to do in the event of a seizure.
  • Prepare your living environment; simple changes may help reduce the risk of physical damage during a seizure.
  • Understand what causes seizures and try to reduce or avoid them.
  • Please keep your overall health in mind, as it can aid in the reduction of seizure activity.
  • Install an alarm or an emergency gadget to summon help during a seizure attack.

Manigrain Er 250 Tablet 10's Substitute

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