AMOXYCILLIN-250MGUlcerative colitis
How does the disease interact with Moxanute 250 Capsule:
Nearly all antibacterial medications have been associated with Clostridioides difficile-associated diarrhoea (CDAD), formerly known as pseudomembranous colitis, which can range in severity from mild diarrhoea to deadly colitis. Lincomycin and clindamycin are typically to blame. Antibacterial treatment disrupts the colon's normal flora, promoting the growth of C. difficile, whose toxins A and B contribute to the emergence of CDAD.
How to manage the interaction:
Moxanute 250 Capsule should be used with caution in patients with a history of gastrointestinal disease, particularly colitis (inflammation in the large intestine) and pseudomembranous colitis (generally characterized by severe, persistent diarrhoea and severe abdominal cramps and sometimes associated with the passage of blood and mucus).
AMOXYCILLIN-250MGInfectious mononucleosis
How does the disease interact with Moxanute 250 Capsule:
When given an aminopenicillin antibiotic for mononucleosis, patients may experience a pruritic, erythematous, maculopapular skin rash. Usually, the rash self-limits and goes away a few days after the offending chemical is stopped. The underlying mechanism has been suggested to be a changed drug metabolism or an immune-mediated process unrelated to drug hypersensitivity. Patients with mononucleosis shouldn't receive treatment with antibiotics containing aminopenicillin.
How to manage the interaction:
Moxanute 250 Capsule should not be used in patients with mononucleosis (contagious infection caused by virus) as it may cause skin rash.
AMOXYCILLIN-250MGType 1 diabetes mellitus
How does the disease interact with Moxanute 250 Capsule:
When utilising Clinitest®, Benedict's Solution, or Fehling's Solution to test for the presence of glucose in urine, high ampicillin concentrations in the urine may provide false-positive results. It is advised to use glucose tests based on enzymatic glucose oxidase reactions,as this effect may also occur with Moxanute 250 Capsule.
How to manage the interaction:
High urine concentrations of Moxanute 250 Capsule may result in false-positive reactions when testing for the presence of glucose in urine using Benedict's Solution or Fehling's Solution. Hence, it is recommended to use glucose tests based on enzymatic glucose oxidase reactions.
AMOXYCILLIN-250MGOther disorders of kidney and ureter, not elsewhere classified
How does the disease interact with Moxanute 250 Capsule:
The kidneys remove the majority of beta-lactam antibiotics as unaltered drugs and, in some situations, as metabolites as well. In patients with poor renal function, the blood concentrations of beta-lactam antibiotics and their metabolites may rise, and their half-lives may be prolonged. According to the individual product package labelling, dosage modifications may be required. These alterations should be based on the severity of the infection as well as the degree of renal impairment. Renal function tests should be carried out on a regular basis during prolonged and/or high-dose therapy because these medicines have occasionally been linked to nephrotoxicity and changes in renal function.
How to manage the interaction:
Dose adjustments may be required in patients with kidney impairment. Kidney function tests should be performed at regular intervals during prolonged and/or high-dose therapy since nephrotoxicity (rapid deterioration in kidney function) and alterations in kidney function have occasionally been associated with the use of Moxanute 250 Capsule.