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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
48 Hrs returnable
COD available

Online payment accepted

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Whats That

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Composition :

TRASTUZUMAB-440MG

Manufacturer/Marketer :

Reliance Formulation Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTINEOPLASTIC

Country of origin

India

Manufacturer/Marketer address

Dhirubhai Ambani Life Sciences Centre, R-282, Ttc Area Of Midc, Thane-Belapur Road, Rabale, Navi Mumbai 400 701.
Other Info - TRA0762

FAQs

Trasturel 440 mg Injection contains Trastuzumab, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.

Inform your doctor whether you have received any other cancer treatment. Trasturel 440 mg Injection may cause a decrease in left ventricular ejection fraction, cardiomyopathy, hypersensitivity reactions, pulmonary toxicity, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, lung problems, are pregnant, are planning to become pregnant, or are breastfeeding before receiving Trasturel 440 mg Injection.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

Avoid consumption of alcohol as it may cause serious side effects.

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Pregnancy

Unsafe

Trasturel 440 mg Injection is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Trasturel 440 mg Injection. Use reliable methods of birth control while on treatment with Trasturel 440 mg Injection.

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Breast Feeding

Unsafe

Avoid nursing your child while on treatment with Trasturel 440 mg Injection as it can cause serious side effects to the baby.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Trasturel 440 mg Injection. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Limited data are available on the effect of Trasturel 440 mg Injection in kidney-impaired patients. Hence, if you have a pre-existing or a history of kidney disease, inform your doctor.

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Children

Unsafe

Trasturel 440 mg Injection is not recommended for use in children as the safety and efficacy are not established.

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Keep Refrigerated. Do not freeze.Prepaid payment required.

About Trasturel 440 mg Injection

Trasturel 440 mg Injection is an anti-cancer medicine used in the treatment of HER2-positive Breast cancer and HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma. Cancer is a disease where the cells grow abnormally and divide uncontrollably. It can also be used when the cancer has spread to other parts of the body.

Trasturel 440 mg Injection contains Trastuzumab as an active ingredient, which belongs to the class of monoclonal antibodies. It works by inhibiting the abnormal growth of cancer cells and, finally, causes the initiation of programmed cell death.

Trasturel 440 mg Injection may cause certain side effects such as abdominal pain, chills, diarrhoea, fatigue, nausea, back pain, bone pain, edema, insomnia, fever, dizziness, headache, vomiting, cough, rash, and injection site reactions. If the side effects persist or bother you, please consult your doctor. Trasturel 440 mg Injection will be administered by a trained doctor. Hence, do not self-administer.

Avoid taking it and inform your doctor if you are allergic to Trasturel 440 mg Injection or its components. Inform your doctor if you have any cardiovascular conditions, lung problems, or liver/kidney disease, as it can cause adverse effects. Trasturel 440 mg Injection is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Trasturel 440 mg Injection

Breast Cancer, Stomach Cancer.

Medicinal Benefits Mweb

Medicinal Benefits

Trasturel 440 mg Injection contains Trastuzumab, which is used for treating patients with HER2-positive breast cancer and HER2-positive metastatic gastroesophageal adenocarcinoma. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of programmed cell death.

Directions for Use

A doctor who is trained or experienced in the administration of chemotherapeutic agents will administer Trasturel 440 mg Injection. Do not self-administer.

Side Effects of Trasturel 440 mg Injection

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Bone pain
  • Headache
  • Fatigue
  • Injection site reactions
  • Pain at the site of injection
  • Dizziness
  • Edema
  • Cough
  • Rash
  • Insomnia

Drug Warnings

Trasturel 440 mg Injection should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any lung problems, cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Trasturel 440 mg Injection may cause left ventricular ejection fraction, cardiomyopathy, pulmonary toxicity, exacerbations of chemotherapy-induced neutropenia, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. Trasturel 440 mg Injection may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Trasturel 440 mg Injection is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

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TrastuzumabEtanercept
Severe
TrastuzumabIdarubicin
Severe

Drug-Drug Interactions

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TrastuzumabEtanercept
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
When Etanercept is used with Trasturel 440 mg Injection 20 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
There may be a possibility of interaction between Trasturel 440 mg Injection 20 ml and Etanercept, but it can be taken if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
TrastuzumabIdarubicin
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Taking Trasturel 440 mg Injection 20 ml with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
Co-administration of Trasturel 440 mg Injection 20 ml with Idarubicin can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience difficulty breathing, fluid retention, or chest pain, consult a doctor. Do not discontinue any medications without a doctor's advice.
TrastuzumabThalidomide
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Taking thalidomide together with Trasturel 440 mg Injection 20 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Trasturel 440 mg Injection 20 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
TrastuzumabInfliximab
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Combining Trasturel 440 mg Injection 20 ml with Infliximab can lead to or increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Trasturel 440 mg Injection 20 ml with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TrastuzumabCladribine
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Combining Trasturel 440 mg Injection 20 ml with Cladribine can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Trasturel 440 mg Injection 20 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
TrastuzumabClozapine
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Co-administration of Trasturel 440 mg Injection 20 ml and clozapine can increase the risk of toxicity.

How to manage the interaction:
Although taking Trasturel 440 mg Injection 20 ml and Clozapine together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not stop using any medications without first talking to your doctor.
TrastuzumabTofacitinib
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Combining Trasturel 440 mg Injection 20 ml with Tofacitinib can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Trasturel 440 mg Injection 20 ml and Tofacitinib, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
TrastuzumabBaricitinib
Severe
How does the drug interact with Trasturel 440 mg Injection 20 ml:
Coadministration of Trasturel 440 mg Injection 20 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Trasturel 440 mg Injection 20 ml and Baricitinib, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ETANERCEPT
  • NATALIZUMAB
  • INDINAVIR
  • EFAVIRENZ
  • ATAZANAVIR
  • GOLIMUMAB

Habit Forming

No

Special Advise

  • Avoid intercourse while on treatment with Trasturel 440 mg Injection.
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) and pulmonary function tests (PFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Trasturel 440 mg Injection Substitute

Substitutes safety advice
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  • Hersima 440 mg Injection 20 ml

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  • Hervycta 440Mg Inj

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