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  3. Perfecine Tablet

Perfecine Tablet, Pack of 1 Tablet
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
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Composition :

PIRFENIDONE-200MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Perfecine Tablet

Perfecine Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease that is marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, due to which it gets difficult to breathe deeply. The scarring makes it hard for the lungs to work properly.
 
Perfecine Tablet contains ‘Pirfenidone’, which helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Perfecine Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis. 

In some cases, you may experience certain common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Perfecine Tablet if you are pregnant or breastfeeding. Perfecine Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Perfecine Tablet as it could lead to increased dizziness. Perfecine Tablet is not recommended for children below 18 years as safety and effectiveness have not been established. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Perfecine Tablet

Idiopathic pulmonary fibrosis

Directions for Use

Take Perfecine Tablet with food. Swallow Perfecine Tablet as a whole with a glass of water; do not chew or crush it.

Medicinal Benefits

Perfecine Tablet is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults. Perfecine Tablet can help effectively slow the rate of lung function decline by 50%. Perfecine Tablet helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better. Perfecine Tablet helps in slowing down the progress of idiopathic pulmonary fibrosis.

Storage

Keep Perfecine Tablet out of reach and sight of children.
Side effects of Perfecine Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Drug Warnings

Do not take Perfecine Tablet if you are allergic to any of its components; if you have a severe or end-stage liver impairment or kidney disease requiring dialysis; if you are taking fluvoxamine (anti-depressant). Inform your doctor if you are taking any medicines that might make you photosensitive, if you smoke or have kidney or liver problems. Consult your doctor before taking Perfecine Tablet if you are pregnant or breastfeeding. Perfecine Tablet may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with Perfecine Tablet as it could lead to increased dizziness. Perfecine Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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PirfenidoneRifampicin
Critical
PirfenidonePhenobarbital
Critical

Drug-Drug Interactions

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PirfenidoneRifampicin
Critical
How does the drug interact with Perfecine Tablet:
Taking Perfecine Tablet with rifampicin can reduce the levels and effects of Perfecine Tablet

How to manage the interaction:
Although there is an interaction between Perfecine Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidonePhenobarbital
Critical
How does the drug interact with Perfecine Tablet:
When Perfecine Tablet is taken with Phenobarbital, it can decrease the effects of Perfecine Tablet.

How to manage the interaction:
Taking Perfecine Tablet with Phenobarbital is not recommended but can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
PirfenidonePrimidone
Critical
How does the drug interact with Perfecine Tablet:
Coadministration of Perfecine Tablet with primidone can reduce levels and the effects of Perfecine Tablet.

How to manage the interaction:
Although there is an interaction between Perfecine Tablet and primidone, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneCarbamazepine
Critical
How does the drug interact with Perfecine Tablet:
Taking Perfecine Tablet with Carbamazepine it reduces the levels and effects of Perfecine Tablet.

How to manage the interaction:
Taking Perfecine Tablet with Carbamazepine is not recommended but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
PirfenidoneVemurafenib
Severe
How does the drug interact with Perfecine Tablet:
Taking Perfecine Tablet with Vemurafenib can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Although there is a possible interaction between Perfecine Tablet and Vemurafenib, you can take these medicines together if prescribed by your doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneTeriflunomide
Severe
How does the drug interact with Perfecine Tablet:
Taking Teriflunomide with Perfecine Tablet may increase the risk of liver damage.

How to manage the interaction:
Although taking Perfecine Tablet and Teriflunomide together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
PirfenidoneFluvoxamine
Severe
How does the drug interact with Perfecine Tablet:
When Perfecine Tablet is taken with Fluvoxamine, it can increase the risk of side effects.

How to manage the interaction:
Taking Perfecine Tablet with Fluvoxamine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
PirfenidoneAmiodarone
Severe
How does the drug interact with Perfecine Tablet:
Co-administration of Amiodarone and Perfecine Tablet may raise the risk of liver issues.

How to manage the interaction:
Even though Amiodarone and Perfecine Tablet interact, they can be used if a doctor prescribes them. Seek medical attention if you have a fever, chills, joint pain or swelling, unusual bleeding or bruises, skin rash, itching, lack of hunger, tiredness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, or yellowing of the skin or eyes. Do not stop taking any medications without visiting a doctor.
PirfenidoneCiprofloxacin
Severe
How does the drug interact with Perfecine Tablet:
When ciprofloxacin is taken Perfecine Tablet, the blood levels of Perfecine Tablet may increase, which may lead to side effects.

How to manage the interaction:
Although taking ciprofloxacin and Perfecine Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you have any of the following symptoms, fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor. Do not discontinue any medications without a doctor's advice.
PirfenidoneRucaparib
Severe
How does the drug interact with Perfecine Tablet:
Taking Perfecine Tablet with Rucaparib can increase the risk or severity of its side effects such as liver disease or gastric problems.

How to manage the interaction:
Co-administration of Perfecine Tablet with Rucaparib can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately.

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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PIRFENIDONE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grape fruit and its products while using Perfecine Tablet can increase the risk of side effects. Avoid grape fruit and its products during treatment with Perfecine Tablet.

Diet & Lifestyle Advise

  • Watch out for triggers that make the cough worse, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow the pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Perfecine Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:39 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Perfecine Tablet helps in reducing the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helps you breathe better.

Perfecine Tablet might make you photosensitive (sensitivity to sunlight). Avoid exposure to sunlight and sunlamps. Wear SPF 50+ sunscreen and protective clothing to reduce exposure to sunlight. Talk to your doctor if you are taking any medicines known to cause photosensitivity. If you notice any symptoms of photosensitivity, consult a doctor.

Do not discontinue Perfecine Tablet without consulting your doctor. To treat your condition effectually, continue taking Perfecine Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Perfecine Tablet.

Diarrhoea might be a side-effect of Perfecine Tablet. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you have severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

No, avoid smoking prior to the start of the treatment and while taking Perfecine Tablet as smoking might alter the effectiveness of Perfecine Tablet.

Weight loss could occur due to loss of appetite. Maintain proper weight by eating healthy food. Your doctor might monitor your weight whilst taking Perfecine Tablet. Consult your doctor if you notice severe weight loss.

Drug-Drug Interactions Checker List

  • FLUVOXAMINE
  • CIPROFLOXACIN
  • ENOXACIN
  • RIFAMPICIN
  • AMIODARONE
  • PROPAFENONE
  • OMEPRAZOLE

Special Advise

  • Your doctor may advise liver function tests prior to the start of the treatment.
  • Regular blood tests are advised at the start of treatment with Perfecine Tablet and monthly for every 6 months, and then for every 3 months thereafter to check the liver functioning.

Disease/Condition Glossary

Idiopathic pulmonary fibrosis (IPF): Idiopathic pulmonary fibrosis belongs to a group of interstitial lung diseases. It is an irreversible chronic disease marked by a progressive decline in lung function. The tissues in the lungs become inflamed and scarred over time, due to which it gets difficult to breathe properly. The scar tissue, known as fibrosis, becomes thick /stiff over time, making it hard for the lungs to work efficiently. This causes decreased lung function, which leads to increased breathlessness and coughing. Breathing difficulties can lead to other medical problems. Symptoms of IPF are shortness of breath, persistent dry cough, loss of appetite, weight loss, rounded and widened tips of the fingers and toes.

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