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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
48 Hrs returnable
COD available

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Overseas Health Care Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIRHEUMATICS

Country of origin

India

Manufacturer/Marketer address

335 KM. MILESTONE, NATIONAL HIGHWAY NO.1, P.O.BOX 25, PHILLAUR , (PUNJAB) INDIA-144 410
Other Info - DML0002

Author Details

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

DM Lef 20 mg Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

DM Lef 20 mg Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of DM Lef 20 mg Tablet . Take DM Lef 20 mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking DM Lef 20 mg Tablet . Alcohol intake, along with DM Lef 20 mg Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take DM Lef 20 mg Tablet while you are pregnant. DM Lef 20 mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take DM Lef 20 mg Tablet while you are breastfeeding. DM Lef 20 mg Tablet passes into breast milk.

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Driving

Caution

DM Lef 20 mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking DM Lef 20 mg Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking DM Lef 20 mg Tablet .

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Children

Unsafe

DM Lef 20 mg Tablet is not approved for children under the age of 18 years.

About DM Lef 20 mg Tablet

DM Lef 20 mg Tablet belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

DM Lef 20 mg Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take DM Lef 20 mg Tablet at the same time every day as prescribed by your doctor. In some cases, DM Lef 20 mg Tablet may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take DM Lef 20 mg Tablet if you are pregnant or planning for pregnancy as DM Lef 20 mg Tablet may cause serious congenital disabilities. DM Lef 20 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk. DM Lef 20 mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with DM Lef 20 mg Tablet as it could lead to increased dizziness and liver damage. DM Lef 20 mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of DM Lef 20 mg Tablet

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits Mweb

Medicinal Benefits

DM Lef 20 mg Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. DM Lef 20 mg Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Directions for Use

Take DM Lef 20 mg Tablet with or without food. Swallow DM Lef 20 mg Tablet as a whole with water; do not crush or chew it.

Side Effects of DM Lef 20 mg Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take DM Lef 20 mg Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. DM Lef 20 mg Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking DM Lef 20 mg Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. DM Lef 20 mg Tablet may cause dizziness, so drive with caution. DM Lef 20 mg Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideClarithromycin
Severe
LeflunomideCorticorelin
Severe

Drug-Drug Interactions

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LeflunomideClarithromycin
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking clarithromycin with DM Lef 20 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with DM Lef 20 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of liver problems such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
LeflunomideCorticorelin
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Using DM Lef 20 mg Tablet together with Corticorelin may raise the risk of severe infections.

How to manage the interaction:
Taking DM Lef 20 mg Tablet with Corticorelin together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideCertolizumab
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Combining Certolizumab pegol with DM Lef 20 mg Tablet can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of DM Lef 20 mg Tablet with Certolizumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, contact your doctor right away. These symptoms include feeling tired, dizzy, or lightheaded, having pale skin, experiencing frequent bleeding or bruising, having a fever or chills, having diarrhea or a sore throat, feeling muscle aches, having trouble breathing, losing weight unexpectedly, or feeling pain or burning when you urinate. Do not discontinue any medications without consulting your doctor.
LeflunomideLenvatinib
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet and lenvatinib can increase the risk of liver problems.

How to manage the interaction:
Taking DM Lef 20 mg Tablet with Lenvatinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, stomach ache, dark urine, liver harm, or bleeding. Do not stop using any medications without first talking to your doctor.
LeflunomideAnakinra
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking anakinra with DM Lef 20 mg Tablet can increase the risk of side effects such as bleeding problems or infections.

How to manage the interaction:
Although there is an interaction between DM Lef 20 mg Tablet and anakinra, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideMacitentan
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet with Macitentan affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking DM Lef 20 mg Tablet and Macitentan together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideBenazepril
Severe
How does the drug interact with DM Lef 20 mg Tablet:
DM Lef 20 mg Tablet can cause liver issues, and combining it with other drugs, such as benazepril, can enhance the risk.

How to manage the interaction:
Co-administration of DM Lef 20 mg Tablet with Benazepril can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or feeling sick, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
LeflunomideTenofovir alafenamide
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet with tenofovir alafenamide can increase the risk of liver problems.

How to manage the interaction:
Taking DM Lef 20 mg Tablet and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
LeflunomideCorticotropin
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Combining Corticotropin with DM Lef 20 mg Tablet can increase the risk of negative side effects.

How to manage the interaction:
Although taking DM Lef 20 mg Tablet and Corticotropin together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not stop using any medications without talking to your doctor.
LeflunomideLevamisole
Severe
How does the drug interact with DM Lef 20 mg Tablet:
When cladribine and levamisole are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
There may be a possibility of interaction between Levamisole and DM Lef 20 mg Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting DM Lef 20 mg Tablet , and for every 6-8 weeks are advised.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

DM Lef 20 mg Tablet Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

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    25.83per tablet
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    26.37per tablet
  • Rumalef 20 Tablet 30's

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    17.90per tablet
  • Cleft 20 Tablet 10's

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    21.83per tablet
  • Lefumide-20 Tablet 10's

    by Others

    24.03per tablet
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