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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
48 Hrs returnable
COD available

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Whats That

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Wallace Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIRHEUMATICS

Country of origin

India

Manufacturer/Marketer address

Wallace Pharmaceuticals Pvt. Ltd., 3rd Floor, Dempo Trade Centre Bldg., Patto Plaza, EDC Complex, Panaji 403001, Goa, India.
Other Info - LEF0032

Author Details

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FAQs

Lefuma 20 mg Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Lefuma 20 mg Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefuma 20 mg Tablet . Take Lefuma 20 mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefuma 20 mg Tablet . Alcohol intake, along with Lefuma 20 mg Tablet , may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefuma 20 mg Tablet while you are pregnant. Lefuma 20 mg Tablet may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefuma 20 mg Tablet while you are breastfeeding. Lefuma 20 mg Tablet passes into breast milk.

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Driving

Caution

Lefuma 20 mg Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking Lefuma 20 mg Tablet .

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Lefuma 20 mg Tablet .

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Children

Unsafe

Lefuma 20 mg Tablet is not approved for children under the age of 18 years.

About Lefuma 20 mg Tablet

Lefuma 20 mg Tablet belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefuma 20 mg Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefuma 20 mg Tablet at the same time every day as prescribed by your doctor. In some cases, Lefuma 20 mg Tablet may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefuma 20 mg Tablet if you are pregnant or planning for pregnancy as Lefuma 20 mg Tablet may cause serious congenital disabilities. Lefuma 20 mg Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Lefuma 20 mg Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefuma 20 mg Tablet as it could lead to increased dizziness and liver damage. Lefuma 20 mg Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefuma 20 mg Tablet

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits Mweb

Medicinal Benefits

Lefuma 20 mg Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefuma 20 mg Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Directions for Use

Take Lefuma 20 mg Tablet with or without food. Swallow Lefuma 20 mg Tablet as a whole with water; do not crush or chew it.

Side Effects of Lefuma 20 mg Tablet

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take Lefuma 20 mg Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefuma 20 mg Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefuma 20 mg Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefuma 20 mg Tablet may cause dizziness, so drive with caution. Lefuma 20 mg Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideAzathioprine
Severe
LeflunomideBenazepril
Severe

Drug-Drug Interactions

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LeflunomideAzathioprine
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Taking Azathioprine with Lefuma 20 mg Tablet can increase the risk of side effects which may lead to anemia, bleeding problems, or infections.

How to manage the interaction:
Taking Lefuma 20 mg Tablet with Azathioprine together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideBenazepril
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Lefuma 20 mg Tablet can cause liver issues, and combining it with other drugs, such as benazepril, can enhance the risk.

How to manage the interaction:
Co-administration of Lefuma 20 mg Tablet with Benazepril can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or feeling sick, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
LeflunomideNaltrexone
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Taking Lefuma 20 mg Tablet and Naltrexone can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Lefuma 20 mg Tablet and Naltrexone, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideEthambutol
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Coadministration of Ethambutol with Lefuma 20 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although taking Ethambutol with Lefuma 20 mg Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
LeflunomidePiroxicam
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Coadministration of Piroxicam and Lefuma 20 mg Tablet can increase the risk of liver damage.

How to manage the interaction:
Although there is a possible interaction between Lefuma 20 mg Tablet and Piroxicam, you can take these medicines together if prescribed by a doctor. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of hunger, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
LeflunomideGefitinib
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Gefitinib can cause higher levels of Lefuma 20 mg Tablet in the blood by reducing its excretion rate. This can increase the risk or severity of liver damage.

How to manage the interaction:
Taking Lefuma 20 mg Tablet with Gefitinib together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideBleomycin
Severe
How does the drug interact with Lefuma 20 mg Tablet:
The use of Lefuma 20 mg Tablet together with bleomycin may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between Bleomycin and Lefuma 20 mg Tablet, you can take these medicines together if prescribed by your doctor. If you notice any signs of infection like fever, chills, or a sore throat, or if you experience symptoms like diarrhea, muscle aches, or difficulty breathing, contact your doctor immediately. Additionally, if you notice any weight loss or pain or burning while urinating, let your doctor know." Do not stop using any medications without a doctor's advice.
LeflunomideBinimetinib
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Lefuma 20 mg Tablet can cause liver problems, and combining it with other drugs, such as Binimetinib, can raise the risk.

How to manage the interaction:
Taking Lefuma 20 mg Tablet with Binimetinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - fever, joint pain, rash, or stomach discomfort, contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideCerivastatin
Severe
How does the drug interact with Lefuma 20 mg Tablet:
Lefuma 20 mg Tablet can cause liver problems, and combining it with other drugs, such as Cerivastatin, can raise the risk.

How to manage the interaction:
Although there is a possible interaction between Lefuma 20 mg Tablet and Cerivastatin, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - fever, joint pain, rash, or stomach pain, contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideHydroxychloroquine
Severe
How does the drug interact with Lefuma 20 mg Tablet:
The combined use of Lefuma 20 mg Tablet and Hydroxychloroquine can increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. This can develop anemia, bleeding problems, or infections.

How to manage the interaction:
Co-administration of Lefuma 20 mg Tablet and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination., consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting Lefuma 20 mg Tablet , and for every 6-8 weeks are advised.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Lefuma 20 mg Tablet Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

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    25.83per tablet
  • Lefra 20 Tablet 10's

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    26.37per tablet
  • Rumalef 20 Tablet 30's

    by Others

    17.90per tablet
  • Cleft 20 Tablet 10's

    by Others

    21.83per tablet
  • Lefumide-20 Tablet 10's

    by Others

    24.03per tablet
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