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  3. LEFRHUM 20MG TABLET

Prescription drug
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LEFRHUM 20MG TABLET, Pack of 10 TABLETS
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48 Hrs returnable
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rxMedicinePrescription drug

Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Rhumasafe Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIRHEUMATICS

Country of origin

INDIA

Manufacturer/Marketer address

U-08, Krishna Place, Near Sohna Chowk, Basai Road, Gurgaon, Haryana 122001, India
Other Info - LEF0017

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Jul 8, 2025 | 9:29 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

LEFRHUM 20MG TABLET is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

LEFRHUM 20MG TABLET may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of LEFRHUM 20MG TABLET. Take LEFRHUM 20MG TABLET for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking LEFRHUM 20MG TABLET. Alcohol intake, along with LEFRHUM 20MG TABLET, may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take LEFRHUM 20MG TABLET while you are pregnant. LEFRHUM 20MG TABLET may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take LEFRHUM 20MG TABLET while you are breastfeeding. LEFRHUM 20MG TABLET passes into breast milk.

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Driving

Caution

LEFRHUM 20MG TABLET may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking LEFRHUM 20MG TABLET.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking LEFRHUM 20MG TABLET.

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Children

Unsafe

LEFRHUM 20MG TABLET is not approved for children under the age of 18 years.

Product Substitutes

Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_4276_003_FinalPL.pdf
  2. https://www.drugs.com/uk/leflunomide-10-mg-tablets-leaflet.html
  3. https://www.drugs.com/cdi/leflunomide.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
  5. https://www.gwh.nhs.uk/media/190756/leflunomide2.pdf

About LEFRHUM 20MG TABLET

LEFRHUM 20MG TABLET belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

LEFRHUM 20MG TABLET contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take LEFRHUM 20MG TABLET at the same time every day as prescribed by your doctor. In some cases, LEFRHUM 20MG TABLET may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take LEFRHUM 20MG TABLET if you are pregnant or planning for pregnancy as LEFRHUM 20MG TABLET may cause serious congenital disabilities. LEFRHUM 20MG TABLET should not be taken by breastfeeding mothers as it passes into breast milk. LEFRHUM 20MG TABLET may cause dizziness, so drive with caution. Avoid consuming alcohol along with LEFRHUM 20MG TABLET as it could lead to increased dizziness and liver damage. LEFRHUM 20MG TABLET may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of LEFRHUM 20MG TABLET

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits Mweb

Medicinal Benefits

LEFRHUM 20MG TABLET belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. LEFRHUM 20MG TABLET is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Directions for Use

Take LEFRHUM 20MG TABLET with or without food. Swallow LEFRHUM 20MG TABLET as a whole with water; do not crush or chew it.

Side Effects of LEFRHUM 20MG TABLET

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take LEFRHUM 20MG TABLET if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. LEFRHUM 20MG TABLET is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking LEFRHUM 20MG TABLET if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. LEFRHUM 20MG TABLET may cause dizziness, so drive with caution. LEFRHUM 20MG TABLET may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideBrigatinib
Severe
LeflunomideNilotinib
Severe

Drug-Drug Interactions

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LeflunomideBrigatinib
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Brigatinib can cause higher levels of Lefrhum 20mg Tablet in the blood by reducing its excretion.

How to manage the interaction:
There may be a possibility of interaction between Lefrhum 20mg Tablet and Brigatinib, but it can be taken if prescribed by a doctor. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideNilotinib
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Taking Lefrhum 20mg Tablet with nilotinib can increase the risk of serious infections and liver problems.

How to manage the interaction:
Taking Lefrhum 20mg Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination, fever, chills, joint pain or swelling, unusual bleeding, fatigue, nausea, vomiting, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LeflunomideNaproxen
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Coadministration of Naproxen and Lefrhum 20mg Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Taking Naproxen and Lefrhum 20mg Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideIbuprofen
Severe
How does the drug interact with Lefrhum 20mg Tablet:
The combined use of Lefrhum 20mg Tablet and Ibuprofen can increase the risk of liver damage.

How to manage the interaction:
Co-administration of Lefrhum 20mg Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideClotrimazole
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Coadministration of Lefrhum 20mg Tablet with clotrimazole can increase the risk of liver problems.

How to manage the interaction:
Although taking Clotrimazole with Lefrhum 20mg Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark coloured urine, light coloured stools, and/or yellowing of the skin or eyes, consult your doctor immediately. Do not discontinue any medication without consulting your doctor.
LeflunomideHydrocortisone
Severe
How does the drug interact with Lefrhum 20mg Tablet:
The combined use of Lefrhum 20mg Tablet and Hydrocortisone can increase the risk of infections.

How to manage the interaction:
Co-administration of Lefrhum 20mg Tablet and hydrocortisone can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideDexamethasone
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Taking Dexamethasone with Lefrhum 20mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Lefrhum 20mg Tablet if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
LeflunomideKetoconazole
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Coadministration of Ketoconazole and Lefrhum 20mg Tablet may cause liver injury.

How to manage the interaction:
Although taking Ketoconazole and Lefrhum 20mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
LeflunomideTacrolimus
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Taking Lefrhum 20mg Tablet together with tacrolimus may increase the risk of serious infections.

How to manage the interaction:
Although taking tacrolimus and Lefrhum 20mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
LeflunomideCarbamazepine
Severe
How does the drug interact with Lefrhum 20mg Tablet:
Taking carbamazepine and Lefrhum 20mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although taking carbamazepine and Lefrhum 20mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or wounds, skin rash, itching, tiredness, nausea, vomiting, abdominal pain, dark urine, light stools, yellowing of the skin or eyes, consult your doctor. Do not stop using any medication without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting LEFRHUM 20MG TABLET, and for every 6-8 weeks are advised.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

LEFRHUM 20MG TABLET Substitute

Substitutes safety advice

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