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  1. Home
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  3. LEF 20 mg Tablet 10's

LEF 20 mg Tablet 10's, Pack of 10 TabletS
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
48 Hrs returnable
Know More
COD available

Online payment accepted

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Whats That

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Meddox Formulations

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

Therapeutic Class

ANTIRHEUMATICS

Country of origin

India

Manufacturer/Marketer address

2/971/A6(A), First Floor Suraksha Arcade, P.M Kutty Road Kozhikode Kozhikode KL 673006
Other Info - LEF0034

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Aug 20, 2024 | 12:51 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

FAQs

LEF 20 mg Tablet 10's is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

LEF 20 mg Tablet 10's may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of LEF 20 mg Tablet 10's. Take LEF 20 mg Tablet 10's for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking LEF 20 mg Tablet 10's. Alcohol intake, along with LEF 20 mg Tablet 10's, may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take LEF 20 mg Tablet 10's while you are pregnant. LEF 20 mg Tablet 10's may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take LEF 20 mg Tablet 10's while you are breastfeeding. LEF 20 mg Tablet 10's passes into breast milk.

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Driving

Caution

LEF 20 mg Tablet 10's may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Please consult your doctor if you have liver impairment before taking LEF 20 mg Tablet 10's.

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Kidney

Caution

Please consult your doctor if you have kidney impairment before taking LEF 20 mg Tablet 10's.

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Children

Unsafe

LEF 20 mg Tablet 10's is not approved for children under the age of 18 years.

Product Substitutes

Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_4276_003_FinalPL.pdf
  2. https://www.drugs.com/uk/leflunomide-10-mg-tablets-leaflet.html
  3. https://www.drugs.com/cdi/leflunomide.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
  5. https://www.gwh.nhs.uk/media/190756/leflunomide2.pdf

About LEF 20 mg Tablet 10's

LEF 20 mg Tablet 10's belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

LEF 20 mg Tablet 10's contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take LEF 20 mg Tablet 10's at the same time every day as prescribed by your doctor. In some cases, LEF 20 mg Tablet 10's may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take LEF 20 mg Tablet 10's if you are pregnant or planning for pregnancy as LEF 20 mg Tablet 10's may cause serious congenital disabilities. LEF 20 mg Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk. LEF 20 mg Tablet 10's may cause dizziness, so drive with caution. Avoid consuming alcohol along with LEF 20 mg Tablet 10's as it could lead to increased dizziness and liver damage. LEF 20 mg Tablet 10's may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of LEF 20 mg Tablet 10's

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits Mweb

Medicinal Benefits

LEF 20 mg Tablet 10's belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. LEF 20 mg Tablet 10's is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Directions for Use

Take LEF 20 mg Tablet 10's with or without food. Swallow LEF 20 mg Tablet 10's as a whole with water; do not crush or chew it.

Side Effects of LEF 20 mg Tablet 10's

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take LEF 20 mg Tablet 10's if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. LEF 20 mg Tablet 10's is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking LEF 20 mg Tablet 10's if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. LEF 20 mg Tablet 10's may cause dizziness, so drive with caution. LEF 20 mg Tablet 10's may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideTacrolimus
Severe
LeflunomideFlurbiprofen
Severe

Drug-Drug Interactions

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LeflunomideTacrolimus
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking LEF 20 mg Tablet together with tacrolimus may increase the risk of serious infections.

How to manage the interaction:
Although taking tacrolimus and LEF 20 mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
LeflunomideFlurbiprofen
Severe
How does the drug interact with LEF 20 mg Tablet:
Using Flurbiprofen with LEF 20 mg Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and LEF 20 mg Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
LeflunomideBendamustine
Severe
How does the drug interact with LEF 20 mg Tablet:
Combining Bendamustine with LEF 20 mg Tablet can increase the likelihood of negative side effects.

How to manage the interaction:
There may be a possibility of interaction between Bendamustine and LEF 20 mg Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms - like an infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideNilotinib
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking LEF 20 mg Tablet with nilotinib can increase the risk of serious infections and liver problems.

How to manage the interaction:
Taking LEF 20 mg Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination, fever, chills, joint pain or swelling, unusual bleeding, fatigue, nausea, vomiting, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LeflunomideDasatinib
Severe
How does the drug interact with LEF 20 mg Tablet:
Using LEF 20 mg Tablet together with dasatinib may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between LEF 20 mg Tablet and Dasatinib, you can take these medicines together if prescribed by a doctor. If you notice any of these symptoms - like body sores, red or inflamed skin, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, fever, and discomfort or burning while urinating, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideBedaquiline
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking bedaquiline with LEF 20 mg Tablet may cause liver problems.

How to manage the interaction:
Although there is an interaction between LEF 20 mg Tablet and Bedaquiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideLisinopril
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking LEF 20 mg Tablet with Lisinopril affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Taking LEF 20 mg Tablet with Lisinopril together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideMitomycin
Severe
How does the drug interact with LEF 20 mg Tablet:
Using LEF 20 mg Tablet together with mitomycin may increase the risk of serious infections.

How to manage the interaction:
Co-administration of LEF 20 mg Tablet with Mitomycin can result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor immediately if you experience symptoms such as fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
LeflunomideTemozolomide
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking Temozolomide with LEF 20 mg Tablet can increase the risk of infections.

How to manage the interaction:
Although taking temozolomide and LEF 20 mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
LeflunomideKetorolac
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking ketorolac with LEF 20 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although taking Ketorolac and LEF 20 mg Tablet together can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite(less desire to eat), fatigue, nausea, vomiting, dark colored urine, light colored stools, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting LEF 20 mg Tablet 10's, and for every 6-8 weeks are advised.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

LEF 20 mg Tablet 10's Substitute

Substitutes safety advice

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